Abstract: In alternative embodiments the invention provides methods for synthesizing AB-007 (also called loxistatin, E64d, EST or ((2S,3S)-trans-epoxysuccinyl-L-leucyl-amido-3-methylbutane ethyl ester) and its acid form E64c (loxistatin acid), and various synthetic intermediates, and deuterated forms of these compounds, and stereoisomers thereof. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof. A synthetic scheme of the invention provides kilogram quantities of AB-007 manufactured according to current good manufacturing practices (cGMP's), consistent with US FDA requirements for human use. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A process is provided for preparing chloromethyl di-tert-butylphosphate (an intermediate for use in preparing water-soluble azole antifungal compounds), wherein potassium di-tert-butylphosphate is reacted with chloromethyl chlorosulfate under mild conditions (15 to 25° C.) in the presence of a base such as sodium carbonate or potassium carbonate, catalyst such as tetrabutylammonium sulfate or tetrabutylammonium chloride and an organic solvent such as dichloromethane or tetrahydrofuran. A process for preparing an azole antifungal agent employing the chloromethyl di-tert-butylphosphate (prepared in accordance with the present invention) is also provided.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: A hologram having a covert image is made by recording on the hologram an object beam that will reconstruct an unrecognizable, scrambled image. The scrambled image can be modified to form a recognizable image by passing the scrambled image through a plate overlying the hologram.

Abstract: A diffuser is disclosed which transmits or reflects incident light into a specific range of angles. In a preferred embodiment, this light is uniformly scattered throughout a cone of angles. The diffuser consists of two parts. The first part diffracts or reflects light into a specific offset angle. The second part, in the preferred embodiment, uniformly scatters the light through a range of angles, which is centered on the offset angle. The diffusers have utility in applications such as screens for wrist watches, computers, calculators, and cell phones.

Abstract: Computer-processed or computer-generated objects can be used to build holograms whose images are close to or straddle the hologram surface. No preliminary or first hologram is required. The hologram is built up from a number of contiguous, small, elemental pieces. Unorthodox views from inside the object are required for the creation of these elements. One method of generating the views employs unique object manipulations. The computational transformations ensure that no singularities arise and that more-or-less conventional modeling and rendering routines can be used. With a second method, a multiplicity of conventional object views are collected. Then, all pixels in these conventional viewplanes are reassigned to new and different locations in the new viewplanes for the elemental views. These methods may be used to build rainbow holograms or full parallax holograms. When properly executed they are visually indistinguishable from other types.

Abstract: A method is disclosed to holographically mark an object in a way that the mark cannot be removed, reproduced, or transferred covertly. The mark can be read from a distance so that the part can be verified as the one and only original. The mark is applied to an undulating or rough surface of the object. The method requires that a reference wave be reflected from the surface and holographically recorded. This wave is then regenerated so that it travels in the opposite direction. This regenerated wave is itself reflected from the surface to form a collimated reference wave which, together with an object wave, is used to form the holographic mark. The recorded image cannot be observed without the presence of the surface itself.

Abstract: Computer-processed or computer-generated objects can be used to build holograms whose images are close to or straddle the hologram surface. No preliminary or first hologram is required. The hologram is built up from a number of contiguous, small, elemental pieces. Unorthodox views from inside the object are required for the creation of these elements. One method of generating the views employs unique object manipulations. The computational transformations ensure that no singularities arise and that more-or-less conventional modeling and rendering routines can be used. With a second method, a multiplicity of conventional object views are collected. Then, all pixels in these conventional viewplanes are reassigned to new and different locations in the new viewplanes for the elemental views. These methods may be used to build rainbow holograms or full parallax holograms. When properly executed they are visually indistinguishable from other types.

Abstract: Computer-processed or computer-generated objects can be used to build holograms whose images are close to or straddle the hologram surface. No preliminary or first hologram is required. The hologram is built up from a number of contiguous, small, elemental pieces. Unorthodox views from inside the object are required for the creation of these elements. One method of generating the views employs unique object manipulations. The computational transformations ensure that no singularities arise and that more-or-less conventional modeling and rendering routines can be used. With a second method, a multiplicity of conventional object views are collected. Then, all pixels in these conventional viewplanes are reassigned to new and different locations in the new viewplanes for the elemental views. These methods may be used to build rainbow holograms or full parallax holograms. When properly executed they are visually indistinguishable from other types.

Abstract: Methods for generating holograms from a computer model of any object employ a combination of numerical and optical means. An illumination model and the light dispersion properties of the object are specified. The hologram is synthesized from a plurality of smaller hologram elements. Each individual element sustains a field of view of the object. The light rays from the object lying within the field of view and along the lines of sight are sampled by the computer. The sample density should not exceed the resolution limit set by the size of the hologram element. Each light ray is specified by a direction and an amplitude function. The hologram element is obtainable from a Fourier Transform fo the sampled rays. In one embodiment, optical means are employed to physically reproduce the sampled light rays using coherent radiation. The reproduced coherent light rays are then interfered with a coherent reference beam to form the hologram element.

Abstract: Methods for generating holograms from a computer model of any object employ a combination of numerical and optical means. An illumination model and the light dispersion properties of the objects are specified. The hologram is synthesized from a plurality of smaller hologram elements. Each individual element sustains a field of view of the object. The light rays from the object lying within the field of view and along the lines of sight are sampled by the computer. The sample density should not exceed the resolution limit set by the size of the hologram element. Each light ray is specified by a direction and an amplitude function. The hologram element is obtainable from a Fourier Transform of the sampled rays. In one embodiment, optical means are employed to physically reproduce the sampled light rays using coherent radiation. The reproduced coherent light rays are then interfered with a coherent reference beam to form the hologram element.

Abstract: Holograms, including diffraction gratings, and methods of making them, that reconstruct an image which changes as the hologram is tilted with respect to the viewer and in a manner that images reconstructed from copies made of the hologram in monochromatic light do not have that motion. The hologram is a valuable security device for authenticating documents or objects to which it is attached since it is extremely difficult to duplicate.

Abstract: Methods for generating holograms from a computer model of any object using a combination of numerical and optical means and the holograms produced thereby. An illumination model is provided to specify sources of light rays and dispersion particles of the object. Each light ray being specified by a path and an intensity function is traceable from a source via the object to a set of points in space by the computer. The hologram is synthesized from a plurality of smaller hologram elements. Each individual element sustains a field of view of the object. The light rays from the object lying within the field of view and along the lines of sight are sampled by the computer. Optical means are employed to physically reproduce the sampled light rays using coherent radiation. The reproduced coherent light rays are then interfered with a coherent reference beam to form the hologram element. Alternatively, the hologram elements are calculated by the computer with an analogous technique.

Abstract: Techniques for making individual narrow lenticular holograms for a composite drum shaped hologram wherein the vertical and horizontal aspects of an object beam and of an image therein are optically processed independently of each other. A very narrow lenticular hologram is made preferably having a width related to the horizontal resolution element size of the reconstruct image in order to minimize undesirable lines in the reconstructed image. The image is predistorted in the hologram construction step to account for a wavelength change if one exists between construction and reconstruction. A master drum hologram is constructed with ultraviolet light utilizing photoresist holographic detector material, in one specific embodiment.

Abstract: Techniques for making individual narrow lenticular holograms for a composite drum shaped hologram wherein the vertical and horizontal aspects of an object beam and of an image therein are optically processed independently of each other. A very narrow lenticular hologram is made preferably having a width related to the horizontal resolution element size of the reconstructed image in order to minimize undesirable lines in the reconstructed image. The image is predistorted in the hologram construction step to account for a wavelength change if one exists between construction and reconstruction. A master drum hologram is constructed with ultraviolet light utilizing photoresist holographic detector material, in one specific embodiment.