Patents by Inventor Kenneth Hofland

Kenneth Hofland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer treatment with topoisomerase-II inhibitor, a bis-dioxypiperazine and radiation
    Patent number: 7906515
    Abstract: The present invention relates to a method of treatment of a tumour cell which comprises administering to a subject in need of treatment an effective amount of a topoisomerase-II poison, e.g. etoposide, in combination with a bis-dioxypiperazine, e.g. dexrazoxane wherein said subject is further treated with radiation.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: March 15, 2011
    Assignee: Topotarget A/S
    Inventors: Kenneth Hofland, Maxwell Sehested, Paul Kristjansen, Annemette Thougaard, Peter Buhl Jensen
  • Cancer Treatment and Cancer Treatment Efficacy Prediction by Blocking and Detecting Protease Inhibitors
    Publication number: 20080019910
    Abstract: Disclosed is a method for improving cancer therapy that relies on induction of apoptosis in malignant cells. It has been found that docking of protease inhibitors PAI-1 and TIMP-1 renders malignant cells expressing these inhibitors more sensitive to apoptosis, whereas non-malignant cells do not change their sensitivity to apoptosis induction. It is therefore possible to increase the effect of various anti-cancer treatments in a rational manner and to predict whether or not an apoptosis-inducing cancer treatment will be effective in a patient or not. The invention also provides for methods of identifying agents that inhibit the apoptosis sensitivity modulating effects of protease inhibitors and to methods of identifying anti-cancer compounds that are not dependent on an apoptosis inducing mechanism which can be modulated by protease inhibitors.
    Type: Application
    Filed: March 30, 2005
    Publication date: January 24, 2008
    Inventors: Maria Romer, Ulrik Lademann, Kenneth Hofland, Peter Jensen, Marion Van Gelder, Johannes Foekens, Anne-Sofie Rasmussen, Nils Brunner, Pernille Usher
  • Cancer treatment with topoisomerase-ii inhibitor, a bis-dioxypiperazine and radiation
    Publication number: 20070185124
    Abstract: The present invention relates to a method of treatment of a tumour cell which comprises administering to a subject in need of treatment an effective amount of a topoisomerase-II poison, e.g. etoposide, in combination with a bis-dioxypiperazine, e.g. dexrazoxane wherein said subject is further treated with radiation.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 9, 2007
    Inventors: Kenneth Hofland, Maxwell Sehested, Paul Kristjansen, Annenette Thougaard, Peter Jensen