Patents by Inventor Kenneth Horton
Kenneth Horton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931713Abstract: A data storage medium is disclosed comprising a solid support matrix including an optional stabilising reagent or reagents in a dry form, for use as a support for artificially synthesised oligonucleotide sequences encoded with data. Preferably the matrix is fibrous (for example cellulose, or glass, fibres) formed into a support of sufficient strength to hold the oligonucleotide sequences. The stabilising reagents are preferably a combination of a weak base, and a chelating agent, optionally, uric acid or a urate salt, and optionally an anionic surfactant.Type: GrantFiled: November 26, 2014Date of Patent: March 19, 2024Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Jeffrey Kenneth Horton, Peter James Tatnell, Robert Stone
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Patent number: 11911070Abstract: A seal assembly for use with an access apparatus includes an integral filter and evacuation port for filtering of fluids, e.g., smoke, from an operating site and removing contaminants and/or odor from the fluids for release of the filtered fluids into the ambient atmosphere. The seal assembly may be a separate subassembly or component which is releasably couplable to the access apparatus or may be integral with the access apparatus. The seal assembly defines its own flow path independent of the insufflation mechanism of the cannula assembly, and is capable of filtering fluids even in the presence of a surgical object positioned within the cannula assembly.Type: GrantFiled: December 2, 2020Date of Patent: February 27, 2024Assignee: Covidien LPInventors: Henry Holsten, Kenneth Horton
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Patent number: 11635354Abstract: Disclosed is a method for capturing the spatial molecular profiling of a biological mass formed from biological material, comprising the steps of: a) providing a transected biological mass, for example a tumour, the transection exposing at least a portion of the mass; b) providing a solid support of an area at least equalling the area of said portion of the mass; c) transferring biological material from the portion of the mass to the support to provide on the support a two dimensional imprint of the biological material present at the portion of the mass; and d) performing a biological assay of the transferred biological material from different predetermined locations of the imprint in order to determine the spatial molecular profile of the portion of the mass.Type: GrantFiled: June 23, 2015Date of Patent: April 25, 2023Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Alison Myfanwy Wakefield, Jeffrey Kenneth Horton, Peter James Tatnell
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Patent number: 11471660Abstract: A vacuum assisted suction and irrigation system includes a suction and irrigation wand, an irrigation fluid supply, a vacuum source, and a fluid pump. The vacuum source is connected to a suction valve of the suction and irrigation wand to provide suction within the suction and irrigation wand. The irrigation fluid supply is connected to the suction and irrigation wand via the fluid pump to supply pressurized irrigation fluid to the suction and irrigation wand. The vacuum source is connected to the fluid pump to pressurize the irrigation fluid being delivered to the suction and irrigation wand.Type: GrantFiled: October 18, 2019Date of Patent: October 18, 2022Assignee: Covidien LPInventors: Jaroslaw Malkowski, Kenneth Horton, Lau Ow
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Patent number: 11175287Abstract: A biometric device, comprising a solid support suitable for receiving biological material and for dry storing that material at room temperature the device further comprising a circuit including means for two way radio frequency communication and including writable data storage. A processing method for such biometric devices, the method including the steps of: a) identifying said device by means of RF communication; b) extracting at least a portion of the biological material from the solid support of the identified device; c) analysing the extracted biological material to obtain biometric data indicative of the biological material; and d) writing said biometric data to the data storage of the biometric device.Type: GrantFiled: April 3, 2017Date of Patent: November 16, 2021Assignee: QIAGEN HEALTHCARE BIOTECHNOLOGIES SYSTEMS GMBHInventors: Jeffrey Kenneth Horton, Peter James Tatnell, Samantha Jane Ogden, Michael John Smith, Leonard Goren, Steven Pepe, Samit Langar, Vincent Francis Pizzi, Craig Robinson
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Publication number: 20210302283Abstract: A biological sample collector 500 comprising a solid support 12 having plural discrete areas (22,24,26,28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.Type: ApplicationFiled: January 28, 2021Publication date: September 30, 2021Inventors: Peter James Tatnell, Jeffrey Kenneth Horton, Christopher George Norey, Alan Stuart Pierce, Robert John
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Patent number: 11008604Abstract: Embodiments of the invention provides a method for detection of at least one analyte derived from a sample, comprising the steps of: a) depositing the sample on a surface of a solid support; b) transferring at least a portion of the solid support to a receptacle suitable for performing a specific binding assay for one or more analytes of interest; c) optionally washing the portion; d) adding a single specific binding partner for each analyte of interest to the receptacle, the binding partner being labelled with an oligonucleotide sequence; e) mixing the portion with nucleic acid amplification reagents; f) amplifying the oligonucleotide sequence; and g) detecting amplified nucleic acid. The invention also provides a kit for use with the method for detection of at least one analyte derived from a sample.Type: GrantFiled: December 8, 2015Date of Patent: May 18, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Kathryn Louise Lamerton, Jeffrey Kenneth Horton, Peter James Tatnell
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Patent number: 10982290Abstract: Disclosed is a method for detecting and quantifying gut flora derived from human faeces, comprising acquiring a solid support containing human faeces; optionally amplifying nucleic acid from the human faeces; and detecting and quantifying the presence of gut flora of interest. Also disclosed is a method for assessing whether a person has type-2 diabetes as well as a kit for detecting and quantifying gut flora from human faeces, comprising a solid support for collecting human faeces; and primer pairs for amplifying 16S rRNA sequence from bacteria of interest.Type: GrantFiled: July 23, 2015Date of Patent: April 20, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Jeffrey Kenneth Horton, Peter James Tatnell, Matthew Sam Morrison, Alan Stuart Pierce
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Publication number: 20210100583Abstract: A seal assembly for use with an access apparatus includes an integral filter and evacuation port for filtering of fluids, e.g., smoke, from an operating site and removing contaminants and/or odor from the fluids for release of the filtered fluids into the ambient atmosphere. The seal assembly may be a separate subassembly or component which is releasably couplable to the access apparatus or may be integral with the access apparatus. The seal assembly defines its own flow path independent of the insufflation mechanism of the cannula assembly, and is capable of filtering fluids even in the presence of a surgical object positioned within the cannula assembly.Type: ApplicationFiled: December 2, 2020Publication date: April 8, 2021Inventors: Henry Holsten, Kenneth Horton
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Patent number: 10955321Abstract: Disclosed is a biological sample collector 500 comprising a solid support 12 having plural discrete areas (22, 24, 26, 28 FIG. 1) for accepting a biological sample, each area being chemically differentiated, for example by having a different chemical treatment sorbed onto the solid support. An envelope 530 encloses the solid support. A cover portion 520 can cover the biological sample after collection to prevent infection. UV light can be applied to the collected sample to reduce the risk of infection.Type: GrantFiled: March 23, 2016Date of Patent: March 23, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Peter James Tatnell, Jeffrey Kenneth Horton, Christopher George Norey, Alan Stuart Pierce, Robert John
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Patent number: 10907148Abstract: The present invention relates to a method and kit for analyte detection. More precisely the invention relates to a method of detecting an analyte, comprising storing short single stranded nucleic acids (10-100 nt), such as aptamers and micro RNA, on a solid support at ambient temperature; and subsequent amplification of said nucleic acids for detection of analyte(s).Type: GrantFiled: August 18, 2016Date of Patent: February 2, 2021Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Jeffrey Kenneth Horton, Peter James Tatnell
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Patent number: 10874426Abstract: A seal assembly for use with an access apparatus includes an integral filter and evacuation port for filtering of fluids, e.g., smoke, from an operating site and removing contaminants and/or odor from the fluids for release of the filtered fluids into the ambient atmosphere. The seal assembly may be a separate subassembly or component which is releasably couplable to the access apparatus or may be integral with the access apparatus. The seal assembly defines its own flow path independent of the insufflation mechanism of the cannula assembly, and is capable of filtering fluids even in the presence of a surgical object positioned within the cannula assembly.Type: GrantFiled: January 22, 2018Date of Patent: December 29, 2020Assignee: Covidien LPInventors: Henry Holsten, Kenneth Horton
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Patent number: 10876938Abstract: The present invention relates to solid supports that are used for the storage and further processing of biological materials. The invention is particularly concerned with solid supports which have at least one surface coated with a chemical that enhances the recovery of the biological material from the support. Methods of preparing and using the solid supports are also described.Type: GrantFiled: February 24, 2012Date of Patent: December 29, 2020Assignee: Global Life Sciences Solutions Operations UK LtdInventors: Jeffrey Kenneth Horton, Peter James Tatnell, Simon Laurence John Stubbs
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Publication number: 20200378958Abstract: The present invention relates to a device and method for sample preparation and collection.Type: ApplicationFiled: April 11, 2018Publication date: December 3, 2020Inventors: Jeffrey Kenneth Horton, Peter James Tatnell, Alan Pierce, Alexander Schenk, Rebecca Ngaire Fullerton
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Publication number: 20200129751Abstract: A vacuum assisted suction and irrigation system includes a suction and irrigation wand, an irrigation fluid supply, a vacuum source, and a fluid pump. The vacuum source is connected to a suction valve of the suction and irrigation wand to provide suction within the suction and irrigation wand. The irrigation fluid supply is connected to the suction and irrigation wand via the fluid pump to supply pressurized irrigation fluid to the suction and irrigation wand. The vacuum source is connected to the fluid pump to pressurize the irrigation fluid being delivered to the suction and irrigation wand.Type: ApplicationFiled: October 18, 2019Publication date: April 30, 2020Inventors: Jaroslaw Malkowski, Kenneth Horton, Lau Ow
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Publication number: 20200129678Abstract: A vacuum assisted suction and irrigation system includes a suction and irrigation wand, an irrigation fluid supply, a vacuum source, and a fluid pump. The vacuum source is connected to a suction valve of the suction and irrigation wand to provide suction within the suction and irrigation wand. The irrigation fluid supply is connected to the suction and irrigation wand via the fluid pump to supply pressurized irrigation fluid to the suction and irrigation wand. The vacuum source is connected to the fluid pump to pressurize the irrigation fluid being delivered to the suction and irrigation wand.Type: ApplicationFiled: October 1, 2019Publication date: April 30, 2020Inventors: Jaroslaw Malkowski, Kenneth Horton, Lau Ow
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Patent number: 10443094Abstract: Provided herein are methods and kits for isothermal nucleic acid amplifications that use a target nucleic acid template; a reaction mixture comprising a DNA polymerase having a strand displacement activity, a deoxyribonucleoside triphosphate (dNTP) mixture, a primer with a 3? end and a 5? end, a molecular crowding reagent, and a buffer solution for amplifying the target nucleic acid template. The buffer solution maintains a low salt concentration of the reaction mixture, and wherein the salt concentration results in a melting temperature (Tm) of the primer at least 10° C. below the reaction temperature. The amplification is effected under isothermal condition.Type: GrantFiled: January 30, 2017Date of Patent: October 15, 2019Assignee: General Electric CompanyInventors: Ryan Charles Heller, John Richard Nelson, Paresh Lakhubhai Patel, Alison Myfanwy Wakefield, Stephen James Capper, Peter James Tatnell, Jeffrey Kenneth Horton
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Patent number: 10252265Abstract: A microfluidic device 100 is disclosed comprising a body 112 including a biological sample S and/or reagent R receiving slot 122. The sample and reagent are carried on a solid support 10. The device 100 includes two punch assemblies 130 for removing portions of the solid support 10 and delivering them, together with the sample and/or reagent(s), to a receiving chamber 126 for subsequent processing. The device can be used for various assays including those which require just the addition of water in the reaction chamber with no pre-treatment of sample prior delivery into the chamber.Type: GrantFiled: February 20, 2015Date of Patent: April 9, 2019Assignee: GE Healthcare UK LimitedInventors: Peter James Tatnell, Jeffrey Kenneth Horton, Geraint Seymour
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Publication number: 20180327811Abstract: The invention generally relates to methods and kits for capturing sperm nucleic acids from or in a biological sample. In one embodiment the method the method comprises, contacting the sample with a lysis solution, having a protamine-DNA complex, to lyse the cell and applying a protamine-specific binding element. This results in the protamine-specific binding element binding to the protamine-DNA to form a complex which may be captured, purified, or detected. Also provided are kits for carrying out the disclosed methods.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Inventors: Patrick McCoy SPOONER, Peter James TATNELL, Jeffrey Kenneth HORTON, John Richard NELSON, Michael John GERDES, Suzana KIEL, Ralf LENIGK, Alexander SCHENK, Wei SUN, Thomas HANSEN
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Publication number: 20180245068Abstract: The present invention relates to a method and kit for analyte detection. More precisely the invention relates to a method of detecting an analyte, comprising storing short single stranded nucleic acids (10-100 nt), such as aptamers and micro RNA, on a solid support at ambient temperature; and subsequent amplification of said nucleic acids for detection of analyte(s).Type: ApplicationFiled: August 18, 2016Publication date: August 30, 2018Inventors: Jeffrey Kenneth HORTON, Peter James TATNELL