Patents by Inventor Kenneth I. Kohn

Kenneth I. Kohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240136037
    Abstract: An application for tracking symptom triggers affecting the microbiome stored on non-transitory computer readable media including an input module for inputting variables from a user in electronic communication with an output variable module, an analysis module for analyzing input variables and output variables, and an output module for presenting results to the user. A method of tracking triggers of symptoms affecting the microbiome in a user, by a user inputting data about nutrition, medication, lifestyle, symptoms due to cancer therapy, pain, and user defined metrics in an application stored on non-transitory computer readable media, performing an analysis on the data, and outputting a result from the data identifying daily activities that effect the user's symptoms and microbiome. A method of adjusting treatment of the microbiome of a patient.
    Type: Application
    Filed: October 17, 2023
    Publication date: April 25, 2024
    Applicant: OptimDosing, LLC
    Inventor: Kenneth I. KOHN
  • Publication number: 20230420142
    Abstract: An application for tracking disease, pain, and mental health symptom triggers including an input module for inputting variables from a user in electronic communication with an output variable module, an analysis module for analyzing input variables and output variables, and an output module for presenting results to the user, wherein the output module provides notice that it is likely that disease or mental health symptoms will appear. A method of preventing the onset of disease or mental health symptoms, by a user inputting data about nutrition, medication, lifestyle, symptoms, and user defined metrics in an application, performing an analysis on the data, outputting a result from the data identifying daily activities that effect the user's disease/mental health and trigger symptoms, including strongest trends, key performance indicators, and tracking over time, and outputting notice that it is likely that disease or mental health symptoms will appear.
    Type: Application
    Filed: May 2, 2023
    Publication date: December 28, 2023
    Applicant: OptimDosing LLC
    Inventor: Kenneth I. KOHN
  • Publication number: 20230233654
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Application
    Filed: September 15, 2022
    Publication date: July 27, 2023
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Patent number: 11491207
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: November 8, 2022
    Assignees: EXCISION BIOTHERAPEUTICS, INC., TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Publication number: 20220336109
    Abstract: An application for tracking disease, pain, and mental health symptom triggers including an input module for inputting variables from a user in electronic communication with an output variable module, an analysis module for analyzing input variables and output variables, and an output module for presenting results to the user. A method of tracking disease, pain, and mental health triggers, by a user inputting data about nutrition, medication, lifestyle, symptoms, pain, and user defined metrics in an application, performing an analysis on the data, and outputting a result from the data identifying daily activities that effect the user's disease/mental health and trigger symptoms. A method of preventing adverse events.
    Type: Application
    Filed: August 14, 2020
    Publication date: October 20, 2022
    Applicant: OptimDosing, LLC
    Inventors: Kenneth I. KOHN, David INWALD, Caitlin Joline BROWN
  • Publication number: 20220028512
    Abstract: An application for tracking cancer therapy symptom triggers stored on non-transitory computer readable media including an input module for inputting variables from a user in electronic communication with an output variable module, an analysis module for analyzing input variables and output variables, and an output module for presenting results to the user. A method of tracking triggers of symptoms in cancer patients, by a user inputting data about nutrition, medication, lifestyle, symptoms due to cancer therapy, pain, and user defined metrics in an application stored on non-transitory computer readable media, performing an analysis on the data, and outputting a result from the data identifying daily activities that effect the user's symptoms due to cancer therapy. A method of adjusting treatment of a cancer patient.
    Type: Application
    Filed: October 5, 2021
    Publication date: January 27, 2022
    Inventor: Kenneth I. KOHN
  • Publication number: 20220028527
    Abstract: A method of dosing food and nutrients for an individual patient, by collecting data from the individual patient including food and nutrients to be taken by the patient, analyzing the data in view of dosing criteria established based on outside data, and determining a dose for each food and nutrient taken by the individual patient. A logic engine for dosing food and nutrients, including an algorithm stored on non-transitory computer readable media for collecting outside data to establish criteria for dosing food and nutrients to an individual patient and patient data and storing outside data and patient data in a database, analyzing the individual patient data in view of criteria established from the outside data, and determining a dose for each food and nutrient to be taken.
    Type: Application
    Filed: July 20, 2021
    Publication date: January 27, 2022
    Inventors: David INWALD, Kenneth I. KOHN
  • Publication number: 20210375485
    Abstract: An application for tracking infectious disease including an input module for inputting variables from a user in electronic communication with an output variable module, an analysis module for analyzing input variables and output variables, and an output module for presenting results to the user. A method of tracking infectious disease, by a user inputting data about symptoms of infectious disease and user defined metrics in an application, performing an analysis on the data, and outputting a result from the data tracking symptom progression, tracking geolocation of symptoms and outbreaks, and tracking trends among individuals without symptoms and individuals with different diseases. A method of monitoring the health of employees and students.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 2, 2021
    Inventors: Kenneth I. KOHN, David INWALD, Caitlin Joline BROWN
  • Publication number: 20210319870
    Abstract: A method of dosing multiple drugs for an individual patient, by collecting data from the individual patient including drugs to be taken by the patient and genetic testing information, analyzing the individual patient data in view of dosing criteria established based on outside patient data, and determining doses of multiple drugs for each drug taken by the individual patient. A logic engine for dosing multiple drugs, including an algorithm stored on non-transitory computer readable media for collecting outside data to establish criteria for dosing multiple drugs to an individual patient and storing the outside data and individual patient data in a database, analyzing the individual patient data in view of criteria established from the outside data, and determining a dose for each drug to be taken.
    Type: Application
    Filed: April 14, 2021
    Publication date: October 14, 2021
    Inventors: David INWALD, Kenneth I. KOHN, Laura S. DELLAL, Caitlin Joline BROWN
  • Publication number: 20210193332
    Abstract: A method of dosing cancer therapies, by collecting patient data including cancer therapies/drugs to be taken, analyzing the data in view of dosing criteria established based on outside data, and determining a dose for each cancer therapy/drug taken. A logic engine for dosing cancer therapies, including an algorithm stored on non-transitory computer readable media for collecting clinical trial data to establish criteria for dosing cancer therapies/drugs to a single patient and patient data and storing the clinical trial data and patient data in a database, analyzing the patient data in view of criteria established from the clinical trial data, and determining a dose for each cancer therapy/drug. A method of adjusting treatment of a cancer patient.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventors: David INWALD, Kenneth I. KOHN
  • Publication number: 20200245925
    Abstract: A method and algorithm for dosing single and multiple drugs for an individual patient includes the step of collecting data from the individual patient. The data includes drugs to be taken by the patient, the patient's age, medical condition, metabolism, and other factors. The method further includes the steps of analyzing the individual patient data in view of dosing criteria established based on patient population data. Based on the analysis, a dose of the single or multiple drugs is recommended. Alternative treatment options can also be recommended.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 6, 2020
    Applicant: OptimDosing, LLC
    Inventors: David INWALD, Kenneth I. KOHN, Laura S. DELLAL
  • Publication number: 20190247470
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Applicants: Excision Bio Therapeutics, Inc., Temple University of the Commonwealth System of Higher Education
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Patent number: 10279014
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 7, 2019
    Assignees: Excision BioTherapeutics, Inc., Temple University of the Commonwealth System of Higher Education
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Publication number: 20180140682
    Abstract: A method of eliminating the risk of JCV activation in a subject undergoing immunosuppressive therapy, by administering an effective amount of a gene editing composition directed toward at least one target sequence in the JCV genome, cleaving the target sequence in the JCV genome, disrupting the JCV genome, eliminating the JCV infection, eliminating the risk of JCV activation, and treating the subject with an immunosuppressive therapy. A pharmaceutical composition including at least one isolated nucleic acid sequence encoding a CRISPR-associated endonuclease and at least one gRNA having a spacer sequence complementary to a target sequence in a JCV DNA, the isolated nucleic acid sequences being included in at least one expression vector. Pharmaceutical compositions including at least one isolated nucleic acid sequence encoding at least one TALEN, at least one ZFN, and gene editing composition of C2c1, C2c3, TevCas9, Archaea Cas9, CasY.1-CasY.
    Type: Application
    Filed: January 8, 2018
    Publication date: May 24, 2018
    Applicants: Excision BioTherapeutics, Inc., Temple University of the Commonwealth System of Higher Education
    Inventors: Kamel Khalili, Thomas Malcolm, Kenneth I. Kohn
  • Patent number: 9925204
    Abstract: A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: March 27, 2018
    Inventors: Toshihisa Kawai, Kenneth I. Kohn
  • Publication number: 20180036285
    Abstract: A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound. A method of treating multiple disease causes, by administering a glycocalyx restoring and maintaining compound to an individual, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage. A method of treating cardiovascular disease. A method of restoring the glycocalyx. A method of reversing inflammation. A method of reversing oxidative damage. A method of treating any disease involving a membrane that has a glycocalyx. A method of treating multiple disease causes. A method of restoring the structural and functional integrity of receptors in the glycocalyx. A method of restoring the glycocalyx and receptors therein and potentiating drug response. A composition for treating disease including the glycocalyx restoring and maintaining compound and an antibody.
    Type: Application
    Filed: April 20, 2016
    Publication date: February 8, 2018
    Applicant: Kardiatonos, Inc.
    Inventors: Josefino B. Tunac, Kenneth I. Kohn
  • Patent number: 9867842
    Abstract: A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound in an oral dosage form. A method of treating cardiovascular disease (CVD), by administering a glycocalyx restoring and maintaining compound to an individual suffering from CVD, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: January 16, 2018
    Assignee: Kardiatonos, Inc.
    Inventors: Josefino B. Tunac, Kenneth I. Kohn
  • Publication number: 20170080006
    Abstract: A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound in an oral dosage form. A method of treating cardiovascular disease (CVD), by administering a glycocalyx restoring and maintaining compound to an individual suffering from CVD, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage.
    Type: Application
    Filed: November 10, 2016
    Publication date: March 23, 2017
    Applicant: Kardiatonos, Inc.
    Inventors: Josefino B. Tunac, Kenneth I. Kohn
  • Publication number: 20170056504
    Abstract: A composition for extending the half-life of a crystalline antibody, including synergistically effective amounts of a half-life-extending compound and a crystalline antibody. A composition for extending the half-life of a crystalline antibody including synergistically effective amounts of lactulose and a crystalline anti-PCSK9 antibody. A method of extending the half-life of a crystalline antibody, by administering a synergistically effective amount of a half-life-extending compound and a crystalline antibody to an individual, and extending the half-life of the crystalline antibody. A method of promoting antibody recycling by affecting a receptor for an antibody to recycle the antibody.
    Type: Application
    Filed: September 1, 2016
    Publication date: March 2, 2017
    Inventors: Kenneth I. Kohn, Toshihisa Kawai
  • Patent number: 9545415
    Abstract: A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: January 17, 2017
    Inventors: Toshihisa Kawai, Kenneth I. Kohn