Abstract: A system is described for carton serialization on a high-speed production line. The system includes conveying apparatus. A printer prints a unique character string on each piece of feed stock to uniquely identify each assembled carton. Folding and gluing apparatus are operatively associated with the conveying apparatus for selectively gluing and folding feed stock to form assembled cartons. An analysis apparatus monitors operation of carton assembly. A rejection device selectively removes defective assembled cartons from the conveying apparatus. A control system is in operative communication with the sensor, printer, folding and gluing apparatus, the analysis apparatus and the rejection device. The control system stores machine operating parameters in a database. The control system controls the printer to print the unique character string on each piece of feed stock responsive to the sensor and storing the unique character string and production time for each carton produced in a database.