Patents by Inventor Kenneth J. Koziol

Kenneth J. Koziol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclophosphamide
    Patent number: 5036060
    Abstract: A mannitol-free lyophilized formulation of cyclophosphamide is disclosed. Sodium chloride is present as an excipient.
    Type: Grant
    Filed: November 24, 1989
    Date of Patent: July 30, 1991
    Assignee: Fujisawa USA, Inc.
    Inventors: Abu S. Alam, Fakrul A. A. Sayeed, Kenneth J. Koziol, John N. Kapoor
  • Cyclophosphamide
    Patent number: 4879286
    Abstract: A storage-stable liquid oncolytic formulation of cyclophosphamide for parenteral administration is presented. Currently utilized lyophilized formulations have inherent diseconomies and increased hazard is associated with reconstitution. The liquid formulations of the present invention comprise a solution of cyclophosphamide with an organic polyol as cosolvent, which provide enhanced shelf-life and greater ease of administration. The polyol is either propylene glycol, polyethylene glycol or glyerol. The solution of cyclophosphamide is either aqueous, or in the case of propylene glycol may constitute 10-30% by weight of an alcohol.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: November 7, 1989
    Assignee: Lyphomed, Inc.
    Inventors: Abu S. Alam, Kenneth J. Koziol, John N. Kapoor