Abstract: The invention is a defensive retainer bottle combination. The bottle contains a defensive spray that immediately immobilizes a person when sprayed upon at the upper extremities of the person. The retainer is made of molded plastic and has upper and lower plates with upturned lips to retain a bottle placed there between. The retainer further has upper and lower springy retainer clips that assure a sure retention of the bottle within the retainer until an emergency requires the use of the bottle whereby a hard pull on the bottle by a hand will dislodge the bottle and make it ready for use. Once the bottle is filled with a defensive fluid. The bottle is inserted into the retainer with a top screw cap first and is then securely caught between the retention clips. The top of the screw cap has an aperture or hole therein into which a nipple penetrates to leak-proof retain the liquid in the bottle. The nipple is part of a rubber plug that is screwed into the top of the retainer.