Abstract: Methods and systems are described for providing end-to-end beamforming. For example, end-to-end beamforming systems include end-to-end relays and ground networks to provide communications to user terminals located in user beam coverage areas. The ground segment can include geographically distributed access nodes and a central processing system. Return uplink signals, transmitted from the user terminals, have multipath induced by a plurality of receive/transmit signal paths in the end to end relay and are relayed to the ground network. The ground network, using beamformers, recovers user data streams transmitted by the user terminals from return downlink signals. The ground network, using beamformers generates forward uplink signals from appropriately weighted combinations of user data streams that, after relay by the end-end-end relay, produce forward downlink signals that combine to form user beams.

Abstract: The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Abstract: An occlusion clip comprising: (a) a spring; (b) a first runner including a first open top and a first open end adjacent the first open top, the first runner including a first interior camming surface partially delineating a first interior cavity that is open by way of the first open top and the first open end; (c) a second runner including a second open top and a second open end adjacent the second open top, the second runner including a second interior camming surface partially delineating a second interior cavity that is open by way of the second open top and the second open end, where the spring is configured to be coupled to the first runner and the second runner, where the first interior cavity is configured to receive a first portion of the spring, where the second interior cavity is configured to receive a second portion of the spring, where the first camming surface is configured to engage a first cam of the spring, and where the second camming surface is configured to engage a second cam of the sprin

Abstract: A towable conveyor for transporting and elevating articles and a method and system for towing a conveyor and conveying articles up inclines is provided. The conveyor system has an elevating carriage and a plurality of support elements for conveying articles up the conveyor. Specifically, the towable conveyor system comprises a conveyor having a support frame, a plurality of support elements, a drive end with a motor, and an idle end; an elevating carriage having a first end interconnected to the support frame of the conveyor, a second with two or more wheels, and a support member extending upwardly from the elevating carriage; a cable system for raising the conveyor into a position of use and for lowering the conveyor into a towing position; one or more locking mechanisms; and a hitch for connecting the conveyor to a rear end of a towing vehicle.

Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: A method of using an occlusion clamp, the method comprising: (a) repositioning a tongs so that tissue interposes the tongs, the tongs comprising a first longitudinal segment operatively coupled proximally to a second longitudinal segment, the tongs including a first spring exerting a proximal bias tending to direct a proximal portion of each of the first and second longitudinal segments toward one another, where each of the first and second longitudinal segments includes a distal free end; (b) repositioning a second spring distally along each of the first and second longitudinal segments to exert a bias tending to direct a distal portion of each of the first and second longitudinal segments toward one another, where repositioning of the tongs so that tissue interposes the tongs precedes repositioning the second spring distally along each of the first and second longitudinal segments.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle part to replace based on received vehicle data including a diagnostic status, a location, and a first route. The memory stores instructions executable by the processor to determine a vehicle operating pattern based on the identified vehicle part and to generate a second route including a second destination based on the vehicle part, the vehicle operating pattern, the location, and a first destination and an expected time of arrival of the first route. The memory stores instructions executable by the processor to navigate the vehicle based on the determined second route and the vehicle operating pattern.

Abstract: A computer is programmed to estimate a total travel time for a vehicle from a current location in a multilevel structure to a destination. The estimated total travel time includes a sum of an estimated travel time from a specified point at the multilevel structure to the destination and estimated travel times for each level of the multilevel structure from a level of the current location to the specified point.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle fault condition, select a vehicle component according to a location of the fault condition in the vehicle and a detected location of a user outside of the vehicle, and actuate the vehicle component.

Abstract: A computer in a vehicle includes a processor programmed to apply, on the vehicle, upon detecting an occupant alertness level below a first threshold, a first periodic component to a first torque applied to one or more first-end wheels and a second periodic component to a second torque applied to one or more second-end wheels.

Abstract: A system, including a processor and a memory, the memory including instructions to be executed by the processor to determine a best-fit snow boundary in an image including a reference object, determine a snow level based on comparing the best-fit snow boundary to the image of the reference object, and operate a vehicle by actuating vehicle components based on the determined snow level.

Abstract: A computer in a vehicle includes a processor programmed to apply, on the vehicle, upon detecting an occupant alertness level below a first threshold, a first periodic component to a first torque applied to one or more first-end wheels and a second periodic component to a second torque applied to one or more second-end wheels.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle fault condition, select a vehicle component according to a location of the fault condition in the vehicle and a detected location of a user outside of the vehicle, and actuate the vehicle component.

Abstract: A system, including a processor and a memory, the memory including instructions to be executed by the processor to determine a best-fit snow boundary in an image including a reference object, determine a snow level based on comparing the best-fit snow boundary to the image of the reference object, and operate a vehicle by actuating vehicle components based on the determined snow level.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle part to replace based on received vehicle data including a diagnostic status, a location, and a first route. The memory stores instructions executable by the processor to determine a vehicle operating pattern based on the identified vehicle part and to generate a second route including a second destination based on the vehicle part, the vehicle operating pattern, the location, and a first destination and an expected time of arrival of the first route. The memory stores instructions executable by the processor to navigate the vehicle based on the determined second route and the vehicle operating pattern.

Abstract: A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

Abstract: A host vehicle includes: motor(s), sensors, processor(s) configured to: (a) iterate a series of future properties, comprising future positions, of nearby first and second vehicles based on determined current properties thereof; (b) associate a blindspot with an iterated future position of the second vehicle; (c) determine whether a future position of the first vehicle occupies the blindspot; (d) if so, transmit a message to the second vehicle including a message activation time.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract: A host vehicle includes: motor(s), sensors, processor(s) configured to: (a) iterate a series of future properties, comprising future positions, of nearby first and second vehicles based on determined current properties thereof; (b) associate a blindspot with an iterated future position of the second vehicle; (c) determine whether a future position of the first vehicle occupies the blindspot; (d) if so, transmit a message to the second vehicle including a message activation time.

Abstract: A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.