Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle part to replace based on received vehicle data including a diagnostic status, a location, and a first route. The memory stores instructions executable by the processor to determine a vehicle operating pattern based on the identified vehicle part and to generate a second route including a second destination based on the vehicle part, the vehicle operating pattern, the location, and a first destination and an expected time of arrival of the first route. The memory stores instructions executable by the processor to navigate the vehicle based on the determined second route and the vehicle operating pattern.

Abstract: A computer is programmed to estimate a total travel time for a vehicle from a current location in a multilevel structure to a destination. The estimated total travel time includes a sum of an estimated travel time from a specified point at the multilevel structure to the destination and estimated travel times for each level of the multilevel structure from a level of the current location to the specified point.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle fault condition, select a vehicle component according to a location of the fault condition in the vehicle and a detected location of a user outside of the vehicle, and actuate the vehicle component.

Abstract: A computer in a vehicle includes a processor programmed to apply, on the vehicle, upon detecting an occupant alertness level below a first threshold, a first periodic component to a first torque applied to one or more first-end wheels and a second periodic component to a second torque applied to one or more second-end wheels.

Abstract: A system, including a processor and a memory, the memory including instructions to be executed by the processor to determine a best-fit snow boundary in an image including a reference object, determine a snow level based on comparing the best-fit snow boundary to the image of the reference object, and operate a vehicle by actuating vehicle components based on the determined snow level.

Abstract: A computer in a vehicle includes a processor programmed to apply, on the vehicle, upon detecting an occupant alertness level below a first threshold, a first periodic component to a first torque applied to one or more first-end wheels and a second periodic component to a second torque applied to one or more second-end wheels.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle fault condition, select a vehicle component according to a location of the fault condition in the vehicle and a detected location of a user outside of the vehicle, and actuate the vehicle component.

Abstract: A system, including a processor and a memory, the memory including instructions to be executed by the processor to determine a best-fit snow boundary in an image including a reference object, determine a snow level based on comparing the best-fit snow boundary to the image of the reference object, and operate a vehicle by actuating vehicle components based on the determined snow level.

Abstract: A system includes a processor and a memory. The memory stores instructions executable by the processor to identify a vehicle part to replace based on received vehicle data including a diagnostic status, a location, and a first route. The memory stores instructions executable by the processor to determine a vehicle operating pattern based on the identified vehicle part and to generate a second route including a second destination based on the vehicle part, the vehicle operating pattern, the location, and a first destination and an expected time of arrival of the first route. The memory stores instructions executable by the processor to navigate the vehicle based on the determined second route and the vehicle operating pattern.

Abstract: A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

Abstract: A host vehicle includes: motor(s), sensors, processor(s) configured to: (a) iterate a series of future properties, comprising future positions, of nearby first and second vehicles based on determined current properties thereof; (b) associate a blindspot with an iterated future position of the second vehicle; (c) determine whether a future position of the first vehicle occupies the blindspot; (d) if so, transmit a message to the second vehicle including a message activation time.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract: A host vehicle includes: motor(s), sensors, processor(s) configured to: (a) iterate a series of future properties, comprising future positions, of nearby first and second vehicles based on determined current properties thereof; (b) associate a blindspot with an iterated future position of the second vehicle; (c) determine whether a future position of the first vehicle occupies the blindspot; (d) if so, transmit a message to the second vehicle including a message activation time.

Abstract: A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

Abstract: A method allows for rapid manufacture of relatively thick adhesive coatings using a continuous process, where a single thin coating is continuously converted into a single thicker adhesive laminate. An exemplary process includes the steps of: (1) producing a web having a first surface with an adhesive layer and a second surface with a release liner; (2) slitting the web longitudinally into a first section and a second section; (3) laminating a backing film to the adhesive layer of the first section; (4) removing the release liner of the laminate of step (3) exposing the adhesive layer of the first section; and (5) laminating the second section to the laminate of step (4), wherein the adhesive layer of the laminate of step (4) is combined with the adhesive layer of the second section.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract: An aerial image relates to a geographic area. The aerial image is analyzed to identify at least one traffic signal in the geographic area. Based at least in part on analyzing the aerial image, a timing prediction is determined for the at least one traffic signal.

Abstract: Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.