Patents by Inventor Kenneth J. Ryan

Kenneth J. Ryan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
    Patent number: 7772218
    Abstract: Syntheses of steroids such as 3-hydroxy-7?-methyl-21-[2?-methoxy-4?-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: August 10, 2010
    Assignee: SRI International
    Inventors: Richard H. Peters, Jyanwei Liu, John G. Johansson, Kenneth J. Ryan, Wan-Ru Chao, Masato Tanabe
  • Animal housing structure and apparatus
    Patent number: 7341020
    Abstract: A housing structure assembly includes a hull and a front wall removably coupled to the hull and configured to simulate a front cover of an air conditioner upon inserting the housing structure assembly into a wall or window opening that is shaped and dimensioned to receive the air conditioner.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: March 11, 2008
    Inventor: Kenneth J. Ryan
  • Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
    Patent number: 6784170
    Abstract: Syntheses of steroids such as 3-hydroxy-7&agr;-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 31, 2004
    Assignee: SRI International
    Inventors: Richard H. Peters, Jyanwei Liu, John G. Johansson, Kenneth J. Ryan, Wan-Ru Chao, Masato Tanabe
  • Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one
    Publication number: 20010039269
    Abstract: Syntheses of steroids such as 3-hydroxy-7&agr;-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.
    Type: Application
    Filed: February 9, 2001
    Publication date: November 8, 2001
    Inventors: Richard H. Peters, Jyanwei Liu, John G. Johansson, Kenneth J. Ryan, Wan-Ru Chao, Masato Tanabe
  • Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
    Patent number: 5428021
    Abstract: Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states associated with elevated HLE levels are also provided, as are pharmaceutical compositions containing the compounds.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: June 27, 1995
    Assignee: SRI International
    Inventors: Charles K. Hiebert, Alan Laibelman, Kenneth J. Ryan
  • C-glycosidic adriamycin analogs
    Patent number: 4705850
    Abstract: Disclosed herein is a new procedure for preparing the C.1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.
    Type: Grant
    Filed: November 23, 1984
    Date of Patent: November 10, 1987
    Assignee: SRI International
    Inventors: Edward M. Acton, Kenneth J. Ryan, Michael Tracy
  • Mesoionic antitumor compositions and methods for using the same in the treatment of cancer
    Patent number: 4329355
    Abstract: Mesoionic anhydro-5-amino-1,2,3,4-oxatriazolium hydroxides and methods of using the same in the treatment of cancer, said compositions containing, as an active ingredient, one or more compounds having the structure ##STR1## wherein R.sup.1 represents a phenyl or substituted phenyl group and R.sup.2 represents hydrogen or a methyl group.
    Type: Grant
    Filed: March 1, 1979
    Date of Patent: May 11, 1982
    Inventors: David W. Henry, Kenneth J. Ryan, Edward W. Grange
  • Septacidin analogs
    Patent number: 4086416
    Abstract: Septacidin analogs, useful as antitumor agents, having the structure ##STR1## where R is a branched or straight chain alkanoyl group of from 12 to 16 carbon atoms. A preferred compound is 6-[4,6-dideoxy-4-(isopalmitoylglycyl)-amino-.beta.-L-glucopyranosylamino]- 9H-purine.
    Type: Grant
    Filed: May 17, 1977
    Date of Patent: April 25, 1978
    Assignee: Stanford Research Institute
    Inventors: Edward M. Acton, Kenneth J. Ryan