Patents by Inventor Kenneth J. Wilcox

Kenneth J. Wilcox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Water and solvent soluble axial hydroxy and mono- and di- carboxylic acid derivatives having high tumor activity
    Patent number: 5196555
    Abstract: Platinum complexes are disclosed in which the formula is ##STR1## wherein A and B are each independently ammine or monodentate amine, or A and B taken together represent a bidentate amine, and A and B are coordinated to the platinum atom through their nitrogen atom; X and Y are each independently halogen; R' is C.sub.1 -C.sub.20 alkanoyl, aroyl, heteroaroyl, or a group selected from the group consisting of ##STR2## wherein u' is an integer from 1 to 5; and R" is hydrogen with the proviso that A, B, X, and Y are structually equatorial substituents with respect to OR'--Pt--OR". These platinum complexes show antitumor activity with relatively lower kidney or bone marrow toxicity.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: March 23, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Murray A. Kaplan, Robert K. Perrone, Joseph B. Bogardus, Kenneth J. Wilcox