Patents by Inventor Kenneth J. Wilson
Kenneth J. Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8087229Abstract: A supersonic combustion apparatus including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one movable combination of a fuel injector and an oxygen injector where the combined fuel injector and the oxygen injector is located within the divergent area of the fixed geometric nozzle, and an exit plane adjacent and downstream to the diverging area. The exit plane Mach speed is varied by heat addition in the diverging area by introduction of a combustible fuel through the fuel injector and oxygen through the oxygen injector and then axially aligning and positioning the combination of the fuel injector and the oxygen injector along the length of the diverging area to obtain a stabilized flame at the exit plane.Type: GrantFiled: January 7, 2008Date of Patent: January 3, 2012Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Warren K. Jaul, Robert G. Burman, Shannon L. Fitzpatrick
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Publication number: 20100281873Abstract: A supersonic combustion apparatus including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one movable combination of a fuel injector and an oxygen injector where the combined fuel injector and the oxygen injector is located within the divergent area of the fixed geometric nozzle, and an exit plane adjacent and downstream to the diverging area. The exit plane Mach speed is varied by heat addition in the diverging area by introduction of a combustible fuel through the fuel injector and oxygen through the oxygen injector and then axially aligning and positioning the combination of the fuel injector and the oxygen injector along the length of the diverging area to obtain a stabilized flame at the exit plane.Type: ApplicationFiled: January 7, 2008Publication date: November 11, 2010Inventors: Kenneth J. Wilson, Warrent K. Jaul, Shannon L. Fitzpatrick, Robert G. Burman
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Patent number: 7705042Abstract: The invention relates to arylamide and hetereoarylamide compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: GrantFiled: October 20, 2005Date of Patent: April 27, 2010Assignee: Janssen Pharmaceutica NVInventors: Carl R. Illig, Shelley K. Ballentine, Jinsheng Chen, Sanath Meegalla, Jonathan Rudolph, Mark J. Wall, Kenneth J. Wilson, Renee DesJarlais, Carl L. Manthey, Christopher M. Flores, Christopher J. Molloy
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Patent number: 7662837Abstract: The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: GrantFiled: October 20, 2005Date of Patent: February 16, 2010Assignee: Janssen Pharmaceutica N.V.Inventors: Carl R. Illig, Shelley K. Ballentine, Jinsheng Chen, Sanath K. Meegalla, M. Jonathan Rudolph, Mark J. Wall, Kenneth J. Wilson, Renee L. Desjarlais, Carl L. Manthey, Christopher Flores, Christopher J. Molloy
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Patent number: 7645755Abstract: The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: GrantFiled: April 20, 2006Date of Patent: January 12, 2010Assignee: Janssen Pharmaceutical N.V.Inventors: Carl R. Illig, Shelley K. Ballentine, Jinsheng Chen, Sanath K. Meegalla, M. Jonathan Rudolph, Mark J. Wall, Kenneth J. Wilson, Renee L. Desjarlais, Carl L. Manthey, Christopher Flores, Christopher J. Molloy
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Patent number: 7296396Abstract: A supersonic combustion apparatus and method for using the same including a fixed geometric nozzle having a converging area, throat, and a diverging area, at least one fuel injection means and at least one flame stabilization means located in the divergent area, and an exit plane adjacent and downstream to the diverging area, where an initial first injection/flame stabilization means is located in the diverging area and the exit plane Mach is varied by heat addition in the diverging area by at least one more fuel injection means.Type: GrantFiled: December 14, 2004Date of Patent: November 20, 2007Assignee: United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Warrent K. Jaul, Shannon L. Fitzpatrick, Robert G. Burman
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Patent number: 6948306Abstract: A supersonic combustion apparatus and method of using the same including a side wall cavity having an enhanced mixing system with ground-based oxygen injection for hypersonic material and engine testing.Type: GrantFiled: December 24, 2002Date of Patent: September 27, 2005Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Timothy P. Parr, Ken Yu, Jaul Warren
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Publication number: 20030208544Abstract: An apparatus for receiving an e-mail message and transmitting the e-mail message to one of a plurality of computers. The apparatus includes a memory having at least one region for storing computer executable program code; and a processor for executing the program code stored in said memory. The program code includes code for receiving the e-mail message, storing the e-mail message in a mailbox corresponding to a user-name, incrementing a counter representative of the number of e-mail messages which are stored in the mailbox, determining if an e-mail client corresponding to the user-name has formed a connection between the one of the plurality of computers and the server, transmitting the e-mail message to the one of the computers if the connection has been formed, and thereafter, deleting the e-mail message from the mailbox and decrementing the counter.Type: ApplicationFiled: October 30, 2001Publication date: November 6, 2003Applicant: Oki Data Americas, Inc.Inventor: Kenneth J. Wilson
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Patent number: 6640549Abstract: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency.Type: GrantFiled: April 24, 2003Date of Patent: November 4, 2003Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Kenneth H. Yu, Timothy Parr, Klaus C. Schadow
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Patent number: 6601393Abstract: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency.Type: GrantFiled: December 3, 2002Date of Patent: August 5, 2003Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Kenneth H. Yu, Timothy Parr, Klaus C. Schadow
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Patent number: 6562840Abstract: The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1—R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.Type: GrantFiled: February 26, 2002Date of Patent: May 13, 2003Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Juan José Marugán
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Publication number: 20030074902Abstract: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency.Type: ApplicationFiled: December 3, 2002Publication date: April 24, 2003Inventors: Kenneth J. Wilson, Kenneth H. Yu, Timothy Parr, Klaus C. Schadow
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Patent number: 6530228Abstract: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency.Type: GrantFiled: May 7, 2001Date of Patent: March 11, 2003Assignee: The United States of America as represented by the Secretary of the NavyInventors: Kenneth J. Wilson, Kenneth H. Yu, Timothy Parr, Klaus C. Schadow
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Patent number: 6515002Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.Type: GrantFiled: September 26, 2001Date of Patent: February 4, 2003Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Roger F. Bone, Scott L. Klein, Troy L. Randle
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Patent number: 6492403Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.Type: GrantFiled: February 9, 2000Date of Patent: December 10, 2002Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Roger F. Bone, Scott L. Klein, Troy L. Randle
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Publication number: 20020162334Abstract: This invention relates to air breathing engines, such as ramjets, scramjets and internal combustion, and more particularly to an active combustion control device for a combustor. In more particularity, the present invention relates to a method and apparatus that applies active combustion control technology to advanced propulsion devices and closed-loop fuel injection at sub-harmonic frequencies of the instability frequency of the combustor. The problem of limited actuator frequency response is addressed by injecting fuel pulses at sub-harmonic frequencies of the instability. The fuel may be liquid, solid or gas. To achieve this desired result, a closed loop controller is designed to determine sub-harmonic frequencies using a divider to divide the instability frequency of a combustor, yielding a fraction of the harmonic frequency.Type: ApplicationFiled: May 7, 2001Publication date: November 7, 2002Inventors: Kenneth J. Wilson, Kenneth H. Yu, Timothy Parr, Klaus C. Schadow
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Patent number: 6403633Abstract: The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.Type: GrantFiled: April 10, 2001Date of Patent: June 11, 2002Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Juan José Marugán
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Publication number: 20020037915Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1Type: ApplicationFiled: September 26, 2001Publication date: March 28, 2002Applicant: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Roger F. Bone, Scott L. Klein, Troy L. Randle
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Publication number: 20010031781Abstract: The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.Type: ApplicationFiled: April 10, 2001Publication date: October 18, 2001Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Juan J. Marugan
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Patent number: 6291514Abstract: The present invention is directed to compounds of Formula I: wherein X is O, S or NR7 and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.Type: GrantFiled: August 11, 1999Date of Patent: September 18, 2001Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventors: Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Kenneth J. Wilson, M. Jonathan Rudolph, Juan José Marugán