Patents by Inventor Kenneth John McLaughlin

Kenneth John McLaughlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stem loop RNA mediated transport of mitochondria genome editing molecules (endonucleases) into the mitochondria
    Patent number: 11492614
    Abstract: The present disclosure relates to a novel CRISPR-Cas9 based system for editing mitochondrial DNA. Aspects of the disclosure provide for mitochondrial translocation of both the guide RNA and the recombinant Cas9 nuclease.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: November 8, 2022
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventors: Kenneth John McLaughlin, Syed-Rehan Ashfaq Hussain
  • Cryopreservation instrument and method of using same
    Patent number: 10834919
    Abstract: A cryopreservation instrument and method of using is provided. The instrument includes a substantially planar elongated member comprising a cryosafe material. The elongated member has a first end and a second end. The first end comprises a cap insert dimensioned and configured to be fit in the interior recess of a vial cap, the second end comprises a biological contact portion configured to accommodate biological material.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: November 17, 2020
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventor: Kenneth John McLaughlin
  • STEM LOOP RNA MEDIATED TRANSPORT OF MITOCHONDRIA GENOME EDITING MOLECULES (ENDONUCLEASES) INTO THE MITOCHONDRIA
    Publication number: 20200032251
    Abstract: The present disclosure relates to a novel CRISPR-Cas9 based system for editing mitochondrial DNA. Aspects of the disclosure provide for mitochondrial translocation of both the guide RNA and the recombinant Cas9 nuclease.
    Type: Application
    Filed: November 15, 2017
    Publication date: January 30, 2020
    Applicant: Research Institute at Nationwide Children's Hospital
    Inventors: Kenneth John McLaughlin, Syed-Rehan Ashfaq Hussain
  • CRYOPRESERVATION INSTRUMENT AND METHOD OF USING SAME
    Publication number: 20170280708
    Abstract: A cryopreservation instrument and method of using is provided. The instrument includes a substantially planar elongated member comprising a cryosafe material. The elongated member has a first end and a second end. The first end comprises a cap insert dimensioned and configured to be fit in the interior recess of a vial cap, the second end comprises a biological contact portion configured to accommodate biological material.
    Type: Application
    Filed: September 2, 2015
    Publication date: October 5, 2017
    Inventor: Kenneth John McLaughlin
  • Hypertonic conditions for cell and oocyte enucleation
    Patent number: 8222480
    Abstract: Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: July 17, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michele Boiani, Kenneth John McLaughlin, Hans R. Schöler, Sigrid Eckardt
  • Stem Cells Derived from Uniparental Embryos and Methods of Use Thereof
    Publication number: 20100233142
    Abstract: Embryonic stem cells derived from uniparental embryos and methods of use thereof are disclosed.
    Type: Application
    Filed: April 12, 2010
    Publication date: September 16, 2010
    Inventors: Kenneth John McLaughlin, Sigrid Eckardt
  • Compositions and Methods for the Efficient and Reproducible Generation of Clone Animals of All Developmental Stages and Methods of Use Thereof
    Publication number: 20100212032
    Abstract: Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols.
    Type: Application
    Filed: March 23, 2010
    Publication date: August 19, 2010
    Inventors: Michele Boiani, Kenneth John McLaughlin, Hans R. Scholer
  • Enhanced production of cloned mammals by zona pellucida-free homologous mammalian embryo aggregation
    Patent number: 7683236
    Abstract: Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: March 23, 2010
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Michele Boiani, Kenneth John McLaughlin, Hans R. Scholer