Abstract: The present disclosure relates to in vitro experiments and in silico computation and machine-learning based techniques to iteratively improve a process for identifying binders that can bind any given molecular target. Particularly, aspects of the present disclosure are directed to obtaining initial sequence data for aptamers that bind to a target, measuring a first signal to noise ratio within the initial sequence data, provisioning, based on the first signal to noise ratio, a first machine-learning system, generating, by the first machine-learning system, a first set of aptamer sequences, obtaining subsequent sequence data for aptamers that bind to the target, measuring a second signal to noise ratio within the subsequent sequence data, provisioning, based on the second signal to noise ratio, a second machine-learning system, generating, by the second machine-learning system, a second set of aptamer sequences, and outputting the second set of aptamer sequences.

Abstract: The present disclosure relates to in vitro experiments and in silico computation and machine-learning based techniques to iteratively improve a process for identifying binders that can bind any given molecular target. Particularly, aspects of the present disclosure are directed to obtaining sequence data for aptamers that bind to a target, where the sequence data has a first signal to noise ratio, generating, by a search process, a first set of aptamer sequences derived from the sequence data, obtaining subsequent sequence data for subsequent aptamers that bind to the target, where the subsequent aptamers includes aptamers synthesized from the first set of aptamer sequences, and the subsequent sequence data has a second signal to noise ratio greater than the first signal to noise ratio, generating, by a linear machine-learning model, a second set of aptamer sequences derived from the subsequent sequence data, and outputting the second set of aptamer sequences.

Abstract: Methods and compositions are provided for the diagnosis and treatment of lung cancers in particular NSCLC associated with amplification or overexpression of the PRO gene, i.e. any of PDGFRA, KIT or KDR.

Abstract: Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.

Abstract: Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.

Abstract: Methods and compositions are provided for the diagnosis and treatment of gastric cancers associated with amplification or overexpression of the c-Myb gene.

Abstract: Methods and compositions are provided for the diagnosis and treatment of lung cancers in particular NSCLC associated with amplification or overexpression of the PRO gene, i.e. any of PDGFRA, KIT or KDR.

Abstract: Methods and compositions are provided for the diagnosis and treatment of colorectal cancers associated with amplification or overexpression of the FGFR2 gene.

Abstract: The invention provides cDNAs, their encoded proteins, and antibodies which may be used in methods for diagnosing and treating cell cycle disorders.