Patents by Inventor Kenneth L. Bost

Kenneth L. Bost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiproliferation factor
    Patent number: 5523290
    Abstract: Mammalian pituitary discovered anti-proliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neural cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8.1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancel cells and autoimmune diseases.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: June 4, 1996
    Assignee: University of Alabama at Birmingham Research Foundation
    Inventors: Robert D. LeBoeuf, J. Edwin Blalock, Kenneth L. Bost
  • Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
    Patent number: 5212072
    Abstract: A method for determining the amino acid sequence of a polypeptide complementary to at least a portion of an original peptide or protein. In one aspect the method involves: (a) determining a first nucleotide sequence of a first nucleic acid coding for the biosynthesis of at least a portion of the original peptide or protein; (b) ascertaining a second nucleotide sequence of a second nucleic acid which base-pairs with the first nucleotide sequence of the first nucleic acid, the first and second nucleic acids pairing in antiparallel directions; and (c) determining the amino acid sequence of the complementary polypeptide by the second nucleotide sequence when read in the same reading frame as the first nucleotide sequence.
    Type: Grant
    Filed: March 7, 1991
    Date of Patent: May 18, 1993
    Assignee: Board of Regents, The University of Texas System
    Inventors: J. Edwin Blalock, Kenneth L. Bost, Eric M. Smith
  • Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
    Patent number: 5077195
    Abstract: A method for determining the amino acid sequence of a polypeptide complementary to at least a portion of an original peptide or protein. In one aspect the method involves: (a) determining a first nucleotide sequence of a first nucleic acid coding for the biosynthesis of at least a portion of the original peptide or protein; (b) ascertaining a second nucleotide sequence of a second nucleic acid which base-pairs with the first nucleotide sequence of the first nucleic acid, the first and second nucleic acids pairing in antiparallel directions; and (c) determining the amino acid sequence of the complementary polypeptide by the second nucleotide sequence when read in the same reading frame as the first nucleotide sequence.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: December 31, 1991
    Assignee: Board of Reagents, The University of Texas System
    Inventors: J. Edwin Blalock, Kenneth L. Bost, Eric M. Smith
  • Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known
    Patent number: 4863857
    Abstract: A method for determining the amino acid sequence of a polypeptide complementary to at least a portion of an original peptide or protein. In one aspect the method involves: (a) determining a first nucleotide sequence of a first nucleic acid coding for the biosynthesis of at least a portion of the original peptide or protein; (b) ascertaining a second nucleotide sequence of a second nucleic acid which base-pairs with the first nucleotide sequence of the first nucleic acid, the first and second nucleic acids pairing in antiparallel directions; and (c) determining the amino acid sequence of the complementary polypeptide by the second nucleotide sequence when read in the same reading frame as the first nucleotide sequence.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: September 5, 1989
    Assignee: Board of Regents, The University of Texas System
    Inventors: J. Edwin Blalock, Eric M. Smith, Kenneth L. Bost