Patents by Inventor Kenneth L. Madsen

Kenneth L. Madsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid conjugated peptide inhibitors of PICK1
    Publication number: 20230346948
    Abstract: The present disclosure relates to a lipid conjugated bivalent peptide ligand which bind to Protein Interacting with C Kinase-1 (PICK1) and thereby inhibit PICK1. The PICK1 inhibitors of the present disclosure comprise a peptide portion comprising two peptide ligands of PICK1, and a non-peptide portion comprising a linker, linking the two peptide ligands, and a lipid. The disclosure furthermore relates to therapeutic and diagnostic use of said PICK1 inhibitor for treatment of diseases or disorders associated with maladaptive plasticity.
    Type: Application
    Filed: March 5, 2021
    Publication date: November 2, 2023
    Inventors: Kenneth L. Madsen, Ulrik Gether, Nikolaj Riis Christensen
  • VIRALLY EXPRESSED INHIBITORS OF PDZ DOMAINS, SUCH AS PICK1 AND USES THEREOF
    Publication number: 20220033450
    Abstract: The present invention relates to virally expressed peptides with high affinity for the PDZ domains, such as the PDZ domain of PICK1. The invention furthermore relates to the therapeutic use of these peptides in prevention and/or treatment of diseases and/or disorders associated with maladaptive plasticity and/or transmission.
    Type: Application
    Filed: October 22, 2019
    Publication date: February 3, 2022
    Applicant: University of Copenhagen
    Inventors: Andreas Toft Sørensen, Kenneth L. Madsen, Nikolaj Riis Christensen, Kristian Strømgaard
  • INHIBITORS OF PICK1 AND USES THEREOF
    Publication number: 20210347821
    Abstract: The present invention relates to peptides and peptide analogues with high affinity for the PDZ domains of PICK1. The peptide or peptide analogue interacts with PICK1, blocking the native protein-protein interactions between PICK1 and its natural ligands. The invention furthermore relates to the therapeutic use of these peptides and peptide analogues in prevention and/or treatment of diseases and disorders associated with maladaptive plasticity, drug addiction and neuropathic pain.
    Type: Application
    Filed: October 22, 2019
    Publication date: November 11, 2021
    Applicant: University of Copenhagen
    Inventors: Kenneth L. Madsen, Kristian Strømgaard, Ulrik Gether, Anders Bach, Nikolaj Riis Christensen