Abstract: Embodiments herein relate to novel compositions and methods for treating viral infections and viral infection-related conditions. In some embodiments, compositions include, but are not limited to, at least one pro-inflammatory cytokine. In accordance with these embodiments, a proinflammatory cytokine can include Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) alone or in combination with other agents administered separately or together. In some embodiments, compositions including GM-CSF can be administered to a subject exposed to, suspected of having been exposed to, or having a viral infection. In other embodiments, the compositions treat, ameliorate or prevent a complication related to viral infection including, but not limited to, a central nervous system infection or condition and a lung infection or condition.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to determine a plurality of tension vectors to be generated within the structure, and to generate a plan for manufacturing the structure. The plan may include tool paths that arrange continuous fibers within the structure to generate the plurality of tension vectors. The processor may also be configured to execute the computer-executable instructions to cause the additive manufacturing machine to follow the plan and manufacture the structure.

Abstract: A vehicle body may have an internal skeleton forming a wing shape, and a skin formed over the internal skeleton. The skin may include a matrix material, and a plurality of continuous fibers encased within the matrix material. The plurality of continuous fibers may curve from a base end near a fore/aft center of the wing shape outward toward leading and trailing edges of the wing shape at a tip end.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to determine a characteristic of an existing point to be used as an anchor for a path of composite material discharged by the additive manufacturing machine. The processor may also be configured to execute the computer-executable instructions to selectively cause the additive manufacturing machine to discharge the path of composite material with a variable ratio of matrix-to-fiber at the existing point that is based on the characteristic.

Abstract: A head is disclosed for use with an additive manufacturing system. The head may include a matrix reservoir, a first nozzle tip, and a second nozzle tip. The head may also include a tip changer mechanically connected between the first nozzle tip, the second nozzle tip, and the matrix reservoir.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to determine a plurality of tension vectors to be generated within the structure, and to generate a plan for manufacturing the structure. The plan may include tool paths that arrange continuous fibers within the structure to generate the plurality of tension vectors. The processor may also be configured to execute the computer-executable instructions to cause the additive manufacturing machine to follow the plan and manufacture the structure.

Abstract: A head is disclosed for an additive manufacturing system. The head may include a reservoir configured to hold a matrix, and a nozzle configured to discharge a continuous fiber received via the reservoir. The head may also include a plurality of supplies of different matrixes in fluid communication with the reservoir.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to cause the additive manufacturing machine to discharge a path of composite material, including a continuous fiber and a matrix at least partially coating the continuous fiber. The processor may also be configured to execute the computer-executable instructions to monitor an energy level within the continuous fiber during discharging, to make a determination that the continuous fiber has lost continuity based on a reduction in the energy level, and to selectively interrupt the discharging based on the determination.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to determine a plurality of tension vectors to be generated within the structure, and to generate a plan for manufacturing the structure. The plan may include tool paths that arrange continuous fibers within the structure to generate the plurality of tension vectors. The processor may also be configured to execute the computer-executable instructions to cause the additive manufacturing machine to follow the plan and manufacture the structure.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to make a determination associated with the structure being a performance-critical part and, based on the determination, selectively implement a first slicing technique or a second slicing technique to divide a virtual model of the structure into a plurality of planes. The processor may be further configured to execute the computer-executable instructions to cause the additive manufacturing machine to deposit composite material in layers corresponding to the plurality of planes.

Abstract: A system is disclosed for use in additively manufacturing a structure. The system may include an additive manufacturing machine, a memory having computer-executable instructions stored thereon, and a processor. The processor may be configured to execute the computer-executable instructions to determine if a tool path to be followed by the additive manufacturing machine during manufacture of the structure is located in free-space or on top of another tool path. When the tool path is located in free-space, the processor may be further configured to execute the computer-executable instructions to make a determination regarding a curvature of the tool path, and to selectively cause the additive manufacturing machine to fabricate a support for the tool path based on the determination.

Abstract: A tension mechanism is disclosed for use with a print head of an additive manufacturing system. The tension mechanism may include a first guide roller configured to receive a continuous reinforcement making up a portion of a composite structure. The tension mechanism may also include a second guide roller spaced apart from the first guide roller and configured to receive the continuous reinforcement in a straight-line trajectory from the first guide roller. The tension mechanism may further include a dancer located between the first and second guide rollers and configured to bias the continuous reinforcement away from the straight-line trajectory. At least one of the first and second guide rollers may have a concave outer profile configured to axially spread out the continuous reinforcement.

Abstract: An additive manufacturing system may include a head configured to discharge a matrix-coated reinforcement, a support configured to move the head during discharging, and a cure enhancer configured to cure the matrix as the matrix-coated reinforcement discharges from the head. The additive manufacturing system may also include a controller in communication with the head, the support, and the cure enhancer. The controller may be configured to receive specifications for a structure to be fabricated, and to determine an anchor point from which the matrix-coated reinforcement will be pulled during fabrication of the structure. The controller may also be configured to regulate operation of the head, the support, and the cure enhancer to manufacture the structure and the anchor point.

Abstract: A head is disclosed for use with an additive manufacturing system. The head may include a housing, and a matrix reservoir disposed inside of the housing. The head may also include at least one roller located inside of the housing and configured to engage at least one of a ribbon and a sheet of reinforcement passing through the head. The head may further include a nozzle fluidly connected to the matrix reservoir, and a cure enhancer located outside of the housing and adjacent the nozzle.

Abstract: A vehicle body may have an internal skeleton forming a wing shape, and a skin formed over the internal skeleton. The skin may include a matrix material, and a plurality of continuous fibers encased within the matrix material. The plurality of continuous fibers may curve from a base end near a fore/aft center of the wing shape outward toward leading and trailing edges of the wing shape at a tip end.

Abstract: A head is disclosed for use with an additive manufacturing system. The head may include a matrix reservoir, and a plurality of nozzles simultaneously fluidly connected to the matrix reservoir. The head may also include at least one hinge connecting the plurality of nozzles.

Abstract: A print head is disclosed for use with an additive manufacturing system. The print head may include a matrix reservoir, and a nozzle base connected to an end of the matrix reservoir. The nozzle base may have a plurality of attachment features formed within an exposed surface. The print head may further include a plurality of available dies separately connectable to the nozzle base via the plurality of attachment features. Attachment of the plurality of available dies to the nozzle base may establish fluid communication with the matrix reservoir.

Abstract: A matrix supply is disclosed for use with an additive manufacturing system. The matrix supply may include a matrix chamber configured to fluidly communicate a liquid matrix with a print head of the additive manufacturing system. The matrix supply may also include a supply conduit fluidly connected to the matrix chamber, a valve disposed within the supply conduit, and an inlet configured to pass a continuous reinforcement through the matrix chamber to the print head of the additive manufacturing system.

Abstract: A vehicle body may have a skeleton formed by a plurality of overlapping layers bonded to each other. Each of the plurality of overlapping layers may be fabricated from a continuous fiber coated with a matrix material. A trajectory of the continuous fiber may be different between adjacent layers of the plurality of overlapping layers.

Abstract: A vehicle body may have an internal skeleton, and a skin formed over the internal skeleton. The skin may include a matrix material, and a plurality of continuous fibers encased within the matrix material. At least one of the plurality of continuous fibers is in tension and has differing levels of tension along its length.