Patents by Inventor Kenneth Lowe

Kenneth Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified tumor-targeted bacteria with reduced virulence
    Publication number: 20070009489
    Abstract: The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors.
    Type: Application
    Filed: April 28, 2005
    Publication date: January 11, 2007
    Inventors: David Bermudes, Kenneth Low
  • Novel proteins and nucleic acids encoding same
    Publication number: 20060084054
    Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 4, 2003
    Publication date: April 20, 2006
    Inventors: John Alsobrook, David Anderson, Jason Baumgartner, Constance Berghs, Ferenc Boldog, Catherine Burgess, Stacie Casman, Elina Catterton, Mohanraj Dhanabal, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, William Grosse, Erik Gunther, Xiaojia Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Nikolai Khramtsov, William LaRochelle, Li Li, Hongping Liang, Kenneth Low, John MacDougall, Timothy Maclachlan, Uriel Malyankar, Kelly McQueeney, Amanda Mezick, Charles Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John Peyman, Xiaozhong Qian, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Sujatha Sukumaran, Edward Szekeres, Corine Vernet, Edward Voss, Adam Wolenc, Mei Zhong, Haihong Zhong
  • Genetically modified tumor-targeted bacteria with reduced virulence
    Publication number: 20050255088
    Abstract: The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as an genetic modification in a biosynthetic pathway gene such as the purl gene. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors.
    Type: Application
    Filed: February 23, 2005
    Publication date: November 17, 2005
    Inventors: David Bermudes, Kenneth Low
  • Emotional state modification method and system
    Publication number: 20050079474
    Abstract: A method of categorizing electronically recallable media, in which a particular user is presented with media samples and permitted to provide personal responses to the media samples. From the personal responses, a determination is made whether the media samples evoke one or more of emotional states in the particular user. The media samples are electronically assigned to one or more of electronically recallable sets corresponding to the emotional states evoked in the particular user by the media samples. An aspect of the method allows for the selective recall of the media samples based on selection of one or more of the electronically recallable sets.
    Type: Application
    Filed: March 11, 2004
    Publication date: April 14, 2005
    Inventor: Kenneth Lowe
  • Vectors for the diagnosis and treatment of solid tumors including melanoma
    Publication number: 20050036987
    Abstract: The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to bacteria, fungi and protists. In certain embodiments the parasites include, but are not limited to, the bacterium Salmonella spp., such as Salmonella typhimurium, the bacterium Mycobacterium avium and the protozoan Leishmania amazonensis. In other embodiments, the present invention is concerned with the isolation of super-infective, tumor-specific, suicide gene-containing strains of parasites for use in treatment of solid tumors.
    Type: Application
    Filed: November 24, 2003
    Publication date: February 17, 2005
    Inventors: John Pawelek, David Bermudes, Kenneth Low
  • Circuit and method for detecting and selecting clock sources
    Patent number: 6292045
    Abstract: A circuit for detecting and selecting one of clock signals of at least two clock sources, is provided. The circuit is coupled to the available clock sources so as to receive their clock signals. The circuit is programmable to choose one of the clock signals designated by a programmed code. Then, the circuit [1] selects the designated clock signal when it has been received and [2] automatically selects the undesignated clock signal when the designated clock signal has not been received and when the undesignated clock signal has been received. Thereafter, the circuit provides the selected clock signal to any device that requires a clock signal in order to operate.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: September 18, 2001
    Assignee: ZiLOG, Inc.
    Inventors: Robert A. Bongiorno, Kenneth Low, Shiyan Pei