Patents by Inventor Kenneth Luehrsen

Kenneth Luehrsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoglobulin variable region cassette exchange
    Publication number: 20060134098
    Abstract: The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the VH and VL sequences of the reference antibody with sequences from human antibody repertoires. The invention also provides novel compositions comprising hybrid immunoglobulin variable domains containing a combination of frameworks (FRs) and CDRs from different antibody clones.
    Type: Application
    Filed: November 16, 2005
    Publication date: June 22, 2006
    Applicant: KaloBios, Inc.
    Inventors: Christopher Bebbington, Kenneth Luehrsen, Geoffrey Yarranton
  • Antibody specificity transfer using minimal essential binding determinants
    Publication number: 20050255552
    Abstract: The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.
    Type: Application
    Filed: January 20, 2005
    Publication date: November 17, 2005
    Applicant: KaloBios, Inc.
    Inventors: Peter Flynn, Kenneth Luehrsen, Robert Balint, Jeng-Horng Her, Christopher Bebbington, Geoffrey Yarranton