Abstract: Antibody molecule-drug conjugates (ADCs) that specifically bind to lipopolysaccharides (LPS) are disclosed. The antibody molecule-drug conjugates can be used to treat, prevent, and/or diagnose bacterial infections and related disorders.

Abstract: A zero turning radius mower park brake system includes a park brake pawl on a transmission which engages a park brake to a pair of independently driven traction wheels. A park brake link may be pivotably mounted to the park brake pawl and connected to a left steering lever and a right steering lever. The park brake link may pivot while moving the park brake pawl forward to a park brake engaged position if only one of the steering levers is moved outward from a neutral traction drive position.

Abstract: Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.

Abstract: Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.

Abstract: A method of packaging compressible insulation material includes feeding insulation material into contact with a mandrel, rolling up the insulation material on the mandrel to form an insulation roll, applying pressure on the insulation material, during the rolling of the insulation material, with a pair of opposed belts which are adapted to contact the roll being formed with an increasing area of contact as the diameter of the roll increases, and increasing tension on the belts as the diameter of the roll increases in order to maintain a substantially constant pressure on the insulation material.

Abstract: An insulation assembly of the invention includes a central roll of compressed, rolled insulation material and six peripheral rolls of compressed, rolled insulation material surrounding the central roll, all of the rolls having longitudinal axes in parallel, each of the rolls being individually restrained, and the entire assembly being enclosed in a wrapper.

Abstract: The present invention provides a coextruded tubing that has been optimized for usage in cryogenic freezing applications. To this end, a coextruded tubing is provided having three layers, a first layer of ethylene vinyl acetate; a second layer of polyolefin; and a third layer of polyvinyl chloride. An improved container for use in cryogenic freezing applications is also provided.

Abstract: A system for coulometric TCO.sub.2 analysis wherein a sample bottle is pressurized by a head space gas having a CO.sub.2 composition which approximates the dissolved CO.sub.2 concentration in the sample. The head space gas transfers to sample to a pipette. The sample is then transferred to a stripper where the sample is degassed. Two carrier gas lines flush the stripper and transfer the CO.sub.2 to a coulometer.

Abstract: Systems and methods for collecting blood substantially free of undesired matter assure that accurate crossmatching and typing of cellular blood components can be done prior to transfusion, even though the cellular components are collected and stored in different containers. The blood containing the undesired matter is collected in a blood collection container. The blood collection container includes a tube that is sealed for retaining samples of the collected blood for later analysis. The collected blood is conveyed out of the blood collection container for removal of undesired matter. The blood substantially free of the undesired matter is collected in a separate transfer container for storage. The distal end of the sealed tube containing the blood samples is attached to the transfer container, while the other end of the sealed tube is disconnected from the original blood collection container.

Abstract: A quick-connect coupling is disclosed for manually joining together pipe or hose sections or the like. A pair of identical coupling bodies are provided, each containing an elastomeric annular face seal, and adapted for sealing engagement with a corresponding coupling body. Members are provided for releasably joining the coupling bodies together. The coupling forms a fluid-tight seal with its mate under low pressure conditions, yet when the coupling is over-pressured, it does not fail catastrophically.

Abstract: A mass transfer device (60) includes a hollow fiber bundle (10) comprising a generally cylindrical core (14) having opposed ends, a plurality of layers of hollow fiber (12) that have been wound around the core, and binding means (48a, 48b, 48c), such as double-sided pressure-sensitive tape that have been wound around the layers of hollow fiber in a plurality of longitudinally spaced locations along the core and intermediate the opposite ends of the core for providing longitudinally spaced support means for the hollow fiber bundle. The hollow fiber bundle is enclosed in a housing (62) having an inner wall (80) which defines a generally circular opening for receiving the hollow fiber bundle except that the inner wall adjust a fluid outlet manifold (74) includes an expansion volume (82) for the hollow fibers that are adjacent that fluid outlet manifold. A screen (88) is provided adjacent the fluid outlet manifold to prevent the fibers from migrating too far into the outlet and to provide a controlled expansion.

Abstract: A washing apparatus for providing a fluid such as hot water to either a spray nozzle or a dishwasher. A thermostatically controlled heated water storage tank supplies fluid to a piping system having a first branch and a second branch. The first branch is directed to the inlet of a pumping system which pumps hot water to a first outlet of the apparatus. The first branch also includes a bypass line. The second branch of the piping system is directed toward a second outlet of the apparatus and includes a flow sensing switch. The first outlet is adapted for connection to a spray wand having a high pressure nozzle therein for supplying high pressure sprayed fluid as desired. The second outlet is adapted for connection to a dishwasher having a solenoid controlled inlet valve. As long as the dishwasher is not running, the pumping system and spray wand may be used normally.

Abstract: The present invention provides a vehicle window regulator for curved windows. The present invention reduces the deflection of the sector arms of the window regulator allowing the use of lighter materials in the regulator components and also allowing the window to be placed into a thinner door panel enclosure than that previously allowable.

Abstract: A heat exchanger (38) is provided which may be used in a mass transfer device (20), such asn an oxygenator or a dialyzer. The heat exchanger comprises a core (40) formed of a corrugated metal having a high thermal conductivity. Each of the corrugations of the core comprises substantially parallel side walls (70, 72). A first fluid, such as blood, is introduced onto the outside of the core. A second fluid, such as water, is introduced into the inside of the core. The first and second fluids will be in heat exchange relationship with each other and the flow of the fluids is substantially uniform resulting from the substantially parallel side walls of the corrugations. The core is formed by providing a flexible metalhose, annealing the flexible metal hose, compressing the annealed hose and expanding the compressed hose to a length that is substantially less than its original length but greater than its length during compression.

Abstract: A mass transfer device (60) includes a hollow fiber bundle (10) comprising a generally cylindrical core (14) having opposed ends, a plurality of layers of hollow fiber (12) that have been wound around the core, and binding means (48a, 48b, 48c) such as double- sided pressure-sensitive tape that have been wound around the layers of hollow fiber in a plurality of longitudinally spaced locations along the core and intermediate the opposite ends of the core for providing longitudinally spaced support means for the hollow fiber bundle. The hollow fiber bundle is enclosed in a housing (62) having an inner wall (80) which defines a generally circular opening for receiving the hollow fiber bundle except that the inner wall adjacent a fluid outlet manifold (74) includes an expansion volume (82) for the hollow fibers that are adjacent that fluid outlet manifold.

Abstract: A heat exchange apparatus including a generally cylindrical hollow housing having an upper end and a lower end, and a heating device disposed in the lower portion of the housing. A heating coil assembly is disposed within the housing over the heating device, and includes a radially inner coil bank and a radially outer coil bank adjacent the inner wall of the housing. An intermediate coil bank is connected between the inner and outer coil bank and includes a plurality of helical convolutions of increasing diameter as they successively occur in an axial direction from the lower end of the housing toward the upper end thereof. A baffle frame assembly interconnects and spacially orients the inner and intermediate coil banks, and radially outwardly deflects heated gases from the heating device.

Abstract: A bundle (12) of hollow fiber (34) is formed by winding a length of hollow fiber around a core (38) from an arm (20) that is in a plane at an acute angle with respect to the longitudinal axis of the core and is between opposite ends of the core. Relative rotation is provided between the longitudinal axis of the core and the position of the winding arm. During winding of the hollow fiber around the core, there is an increase in the ratio of (a) the angular velocity of the wind and (b) the relative rotational velocity between the longitudinal axis of the core and the position of the winding arm. In this manner, the void fraction of radially-outward annuli of the wound bundle is less than the void fraction would be if the ratio remained constant.

Abstract: A continuous monogrammer utilizing a peripheral frame to support therein a pair of rollers and drive mechanism therefor to transport a continuous strip of material laterally beneath the sewing machine needle. A bridge straddles the rollers and is slidingly supported on a pair of shafts on opposite sides of the peripheral frame. The bridge is affixed to the sewing machine presser bar so as to elevate the frame and rollers thereby. A second drive mechanism is carried by the bridge and provides an operative connection between the bridge and the peripheral frame so as to move the peripheral frame and the work fabric upon which it rests in the longitudinal direction beneath the sewing needle.

Abstract: A machine forming stitches invisible on one work face, with curved needle, looper, work feed, and associated drive mechanisms arranged beneath the work. After convenient assembly of these mechanisms on bosses rising from a frame base, a frame cover is attached carrying a presser and a device for forming a work ridge in the needle path. A compartment extending across this machine front is formed within the frame to accommodate the needle thread supply and controls.