Patents by Inventor Kenneth M. Wells

Kenneth M. Wells has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing carbapenem intermediates
    Patent number: 6194568
    Abstract: The invention describes an improved process for synthesizing 1-&bgr;-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention. The invention relates to the synthesis of a compound of formula 3: wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: February 27, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark S. Jensen, Yi Xiao, Chunhua Yang, Kenneth M. Wells, Nobuyoshi Yasuda
  • Side chains synthesis for an anthiarrhythmic compound
    Patent number: 5922906
    Abstract: The present invention is directed to an improved process for preparing the phenylacetic acid side chain of the compound of the formula ##STR1## This compound exhibits utility as a Class III antiarrhythmic agent.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: July 13, 1999
    Assignee: Merck & Company, Inc.
    Inventors: Joseph E. Lynch, Yao-Jun Shi, Kenneth M. Wells
  • Process for phosphodiesterase IV inhibitors
    Patent number: 5919937
    Abstract: The invention encompasses a novel process for the formation of enantiomerically enriched mixtures of compounds of Formula I, which are useful precursors in the synthesis of phosphodiestersae IV inhibitors.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: July 6, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Joseph E. Lynch, Kenneth M. Wells, Yao-Jun Shi
  • Process for making HIV protese inhibitors
    Patent number: 5861512
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: January 19, 1999
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kai Rossen, Paul Reider, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells
  • Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
    Patent number: 5777123
    Abstract: The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: July 7, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Joseph E. Lynch, Yao-Jun Shi, Kenneth M. Wells
  • Process for making HIV protease inhibitors
    Patent number: 5693803
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 2, 1997
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Kai Rossen, Paul Reider, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells
  • Process for making HIV protease inhibitors
    Patent number: 5637711
    Abstract: Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Paul Reider, Kai Rossen, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells
  • Process for making HIV protease inhibitors
    Patent number: 5618939
    Abstract: A process is disclosed for making a chiral compound of the formula ##STR1## comprising reacting an epoxide compound of the formula ##STR2## and an amide of the formula ##STR3## in the presence of a strong base at a low temperature.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Paul Reider, Kai Rossen, Richard J. Varsolona, Ralph P. Volante, Kenneth M. Wells