Patents by Inventor Kenneth Maiese

Kenneth Maiese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the temporal analysis of programmed cell death in living cells
    Patent number: 6063580
    Abstract: Methods for determining the induction and assessing the course of programmed cell death (PCD) over time in living cells are provided. The methods of the present invention comprise the steps of contacting viable cells with a detectable reagent having high affinity for phosphatidylserine, qualitatively and/or quantitatively detecting the cells that have reacted with the detectable reagent, removing the detectable reagent, recontacting the cells with the detectable reagent and qualitatively and/or quantitatively detecting cells that have reacted with the detectable reagent. The methods of the present invention are performed with cells maintained in a viable state, thereby allowing detection of the induction and assessment of the progression of PCD over time.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: May 16, 2000
    Assignee: Wayne State University
    Inventors: Kenneth Maiese, Andrea M. Vincent
  • Methods for the temporal analysis of programmed cell death in living cells
    Patent number: 5939267
    Abstract: Methods for determining the induction and assessing the course of programmed cell death (PCD) over time in living cells are provided. The methods of the present invention comprise the steps of maintaining a viable cell on a slide, staining the cell with annexin V to label any phosphatidylserine residues which may be present on the cell surface, visualizing the stained cell, removing the stain, sustaining the cell in culture, restaining the cell with annexin V to again label any phosphatidylserine residues present on the cell surface and visualizing the stained cell. The methods of the present invention are performed with cells maintained in a viable state, thereby allowing detection of the induction and assessment of the progression of PCD over time.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: August 17, 1999
    Assignee: Wayne State University
    Inventors: Kenneth Maiese, Andrea M. Vincent
  • Treatment of stroke or in anticipation of the occurrence of brain ischemia
    Patent number: 5519035
    Abstract: Administration of protein kinase C inhibitors protect neuronal cells from death from cerebral ischemia. Model for screening compounds for potential for protecting neuronal cells from death from cerebral ischemia comprises adding the compounds to medium containing neuronal cells before, at the same time as, and/or after nitric oxide administration.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: May 21, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Kenneth Maiese, John A. Wagner
  • Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia
    Patent number: 5500420
    Abstract: Administration of metabotropic glutamate receptor agonists protect neuronal cells from death from cerebral ischemia. Examples of agents are L(+)-2-amino-4-phosphonobutyric acid, trans-amino cyclopentane dicarboxylic acid, (1S,3R)-amino cyclopentane dicarboxylic acid and quisqualic acid.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: March 19, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Kenneth Maiese