Patents by Inventor Kenneth Marby

Kenneth Marby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Patent number: 10568876
    Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: February 25, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jason Imbriglio, Rui Liang, Clare London, Kenneth Marby, James Tata, Ming You, Yusheng Xiong
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20190062342
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: March 23, 2018
    Publication date: February 28, 2019
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
    Publication number: 20170273965
    Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
    Type: Application
    Filed: August 31, 2015
    Publication date: September 28, 2017
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jason Imbriglio, Rui Liang, Clare London, Kenneth Marby, James Tata, Ming You, Yusheng Xiong
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20160280718
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: November 4, 2015
    Publication date: September 29, 2016
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Antibacterial agents
    Patent number: 9200026
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 1, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-Kong Shue, Yoshitaka Ichikawa, Chan-Kou Hwang, David Rabuka, Sulan Yao
  • Antibacterial agents
    Patent number: 7601695
    Abstract: Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides as antibacterial agents.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: October 13, 2009
    Assignee: Optimer Pharmaceuticals, Inc.
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, David Rabuka, Sulan Yao, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang
  • Synthesis of glycopeptides with superior pharmacokinetic properties
    Publication number: 20090247732
    Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 1, 2009
    Applicant: Optimer Pharmaceuticals, Inc.
    Inventors: Jonathan Duffield, Kenneth Marby, Sean O'Hare, Chan-Kou Hwang, Yoshitaka Ichikawa
  • NOVEL ANTIBACTERIAL AGENTS
    Publication number: 20090209593
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 20, 2009
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, David Rabuka, Sulan Yao, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang
  • Novel antibacterial agents
    Publication number: 20060100164
    Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
    Type: Application
    Filed: March 5, 2004
    Publication date: May 11, 2006
    Inventors: Chang-Hsing Liang, Jonathan Duffield, Alex Romero, Yu-Hung Chiu, Steve Sucheck, Kenneth Marby, Youe-kong Shue, Yoshi Ichikawa, Chan-Kou Hwang, Alex Romero, Yu-Hung Chiu, David Rabuka
  • Aminoglycoside antibiotics as novel anti-infective agents
    Publication number: 20040058880
    Abstract: This invention relates to novel aminoglycoside compounds having antibacterial and anti-infective activity and to pharmaceutical compositions, methods of making and methods of treatment employing the same.
    Type: Application
    Filed: June 26, 2003
    Publication date: March 25, 2004
    Inventors: Chang-Hsing Liang, Kenneth Marby, David Rabuka, Alex Romero, Paul W. M. Sgarbi, Steven J. Sucheck, Youe-Kong Shue, Sulan Yao