Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: A method for in-service RAM testing in computer systems and networks having a virtual memory. The method involves identifying a number n of physical memory units pi, i=1 . . . n, in the RAM and a number n−1 of virtual memory units vj, j=1 . . . n−1, in the virtual memory, performing a one-to-one mapping to map the physical memory units pi to virtual memory units vj such that a physical memory unit px is left unmapped, and then testing data in the unmapped physical memory unit px by destructive or non-destructive tests. After the test data from another physical memory unit py is copied to physical memory unit px and a one-to-one re-mapping of physical memory units pi to virtual memory units vj is performed such that physical memory unit py is left unmapped. The data in physical memory unit py is then tested and the steps of copying, one-to-one re-mapping and testing can be repeated until all physical memory units pi are tested.

Abstract: A system for managing signal power levels in an optical network. The optical network comprises a plurality of nodes having logic to receive and transmit optical signals over a plurality of network interconnections. The system includes a method wherein each of the nodes is provided configuration parameters, each of the nodes is configured based on the configuration parameters, power parameter information is exchanged between the nodes, at least some of the nodes are re-configured based on the power parameter information and the steps of exchanging power parameter information and re-configuring at least some of the nodes are repeated until the optical network is fully configured so that the optical signals have selected signal power levels.

Abstract: A method for in-service RAM testing in computer systems and networks having a virtual memory. The method involves identifying a number n of physical memory units pi, i=1 . . . n, in the RAM and a number n−1 of virtual memory units vj, j=1 . . . n−1, in the virtual memory, performing a one-to-one mapping to map the physical memory units pi to virtual memory units vj such that a physical memory unit px is left unmapped, and then testing data in the unmapped physical memory unit px by destructive or non-destructive tests. After the test data from another physical memory unit py is copied to physical memory unit px and a one-to-one re-mapping of physical memory units pi to virtual memory units vj is performed such that physical memory unit py is left unmapped. The data in physical memory unit py is then tested and the steps of copying, one-to-one re-mapping and testing can be repeated until all physical memory units pi are tested.