Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Systems and methods are described which determine, in real time, and without impeding the natural flow of vehicles, which vehicles entering a predetermined area is there for commercial purposes, and designate a charge for the commercial purpose.

Abstract: Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selectivity for MCT4 over MCT1.

Abstract: A flange flush tool includes an outer tube having a first end and a second end, the first end configured to engage the flange, and a shield tube within the outer tube. A channel is defined between an outer surface of the shield tube and an inner surface of the outer tube. The shield tube is configured to move longitudinally within the outer tube.

Abstract: A system for checking modifications made to re-configurable hardware and software is described.

Abstract: A method, performed by a computer, for volumetrically determining a mid-sagittal plane (MSP) from a plurality of magnetic resonance (MR) images of a brain is disclosed. The plurality of MR images is received and converted into a 3D volume image defined in a 3D coordinate space. Semantic segmentation of an anterior commissure (AC) region, a posterior commissure (PC) region, and a third ventricle region in the 3D volume image is performed based on a pre-trained segmentation model to generate a 3D mask image labeled with the AC region, the PC region, and the third ventricle region. Based on the labeled 3D mask image, a 3D volumetric image of the segmented third ventricle region is constructed. The MSP is determined based on the 3D volumetric image of the third ventricle region.

Abstract: Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selectivity for MCT4 over MCT1.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A gaming machine is configured to play one of a plurality of games. The gaming machine includes a display including a first display area, a second display area, and a third display area. A game controller executes instructions to display on the first display area a carousel of first representations of a plurality of games and display on a second display area second representations of the plurality of games, and, in response to receipt of a first input, display a rotation of the first representations in the carousel in the first display area, display a plurality of selectable denominations in the third display area, and in response to receipt of a second input with respect to a selected representation of the first representations in the carousel, highlight a second representation of the second representations corresponding to the selected representation.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A personal computer includes a motherboard, video graphics adapter, mod board, switching board and single board computer. The switching board includes a microcontroller and USB and video switching circuits. A networked server includes a limitations database. The mod board is connected to the front panel signals of the motherboard and the main switching board connects to the mod board, the single board computer and the video graphics adapter. Upon user input to a program running on the single board computer, the program makes a server request. Response data is sent to the microcontroller on the switching board and, if time is available, switches the USB keyboard to the motherboard, the video output to the video graphics adapter and signals the mod board to power on the motherboard. The program on the single board computer signals the switching board to switch back video, USB and motherboard power when allowed time expires.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: The present disclosure relates generally to systems and methods of managing normally independent or unassociated business artifacts using an integrated business artifact management system (IBAMS) to deliver a cohesive, linked, and traceable network of related and integrated artifacts that supports improved business knowledge and impact analysis. A disclosed IBAMS includes a collection of integrated business artifacts stored in a memory of the IBAMS and a plurality of links, each associated with a respective data island of a plurality of data islands. Each link includes a set of instructions that, when executed by a processor of the IBAMS, cause the processor to: receive business artifacts from the respective data island; generate representations that are abstractions of the business artifacts received from the respective data island; and store and integrate the representations in the collection of integrated business artifacts.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A topical composition for treating discomfort of the skin and mucous membranes comprising therapeutically effective amounts of Aloe barbadensis (aloe vera) leaf gel, Camellia sinensis leaf (green tea) extract, Hamamelis virginiana (witch hazel) extract, tocopheryl acetate (vitamin E), and hydrocortisone, formulated into a physical form selected from the group consisting of lotion, cream, emollient, ointment, spray, aerosol and gel. The Aloe barbadensis leaf gel and Hamamelis virginiana extract are both present in an amount up to 50 percent by weight. The Camellia sinensis leaf extract and tocopheryl acetate are both present in an amount up to 3 percent by weight. The hydrocortisone is present in an amount up to 1 percent by weight.

Abstract: A computing device can be controlled based on changes in the angle of a user's head with respect to the device, such as due to the user tilting the device and/or the user tilting his head with respect to the device. Such control based on the angle of the user's head can be achieved even when the user is operating the device “off-axis” or when the device is not orthogonal and/or not centered with respect to the user. This can be accomplished by using an elastic reference point that dynamically adjusts to a detected angle of the user's head with respect to the device. Such an approach can account for differences between when the user is changing his natural resting position and/or the resting position of the device and when the user is intending to perform a gesture based on the angle of the user's head relative to the device.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.