Abstract: A coupling assembly includes a body member and at least one end member attached to the body member. At least one connection arrangement is situated between the body member and the at least one end member, respectively. The at least one connection arrangement includes a plurality of bushings. A plurality of fasteners are each respectively received by the plurality of bushings to fasten the body member to the at least one end member. Each one of the plurality of bushings are rotationally fixed about their center longitudinal axes by the at least one connection arrangement.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A composition and method for treating itching, burning and discomfort of the skin and/or mucous membranes including the perianal and vaginal regions. The composition comprising therapeutically effective amounts of Aloe barbadensis leaf gel, deionized water, C12-15 alkyl benzoate, Camellia sinensis leaf extract, ceteareth-20, cetearyl alcohol, cetyl alcohol, ethylhexylglycerin, glycerin stearate, Hamamelis virginiana extract, Helianthus annus seed oil, PEG-100 stearate, petrolatum, phenoxyethanol, stearyl alcohol, tocopheryl acetate, Zemea propanediol and hydrocortisone.

Abstract: A method for configuring a process control system includes coupling an I/O module to a PLC coupled to field devices. For each field device, the PLC has registers storing data of values associated with the field device. The PLC is configured such that each field device is associated with a PLC control tag, and each control tag is associated with tag parameters corresponding to the registers for the field device. The method includes configuring the I/O module to associate the tag parameters with corresponding controller parameters such that, for each control tag, there is a set of controller parameters associated with the tag parameters for the control tag. The method includes instantiating an integration object and associating the integration object with one of the control tags.

Abstract: A first hardware island is defined as including at least a first compute cluster. First backup infrastructure is associated with the first compute cluster. A second hardware island is defined as including at least a second compute cluster. Second backup infrastructure is associated with the second compute cluster. A partnership is established between the first and second compute clusters. A selection of a backup policy to be associated with a workload is received. The workload is provisioned to the first compute cluster for processing and the selected backup policy is provided to the second backup infrastructure.

Abstract: A gaming machine is configured to play one of a plurality of games. The gaming machine includes a display including a first display area, a second display area, and a third display area. A game controller executes instructions to display on the first display area a carousel of first representations of a plurality of games and display on a second display area second representations of the plurality of games, and, in response to receipt of a first input, display a rotation of the first representations in the carousel in the first display area, display a plurality of selectable denominations in the third display area, and in response to receipt of a second input with respect to a selected representation of the first representations in the carousel, highlight a second representation of the second representations corresponding to the selected representation.

Abstract: An object model is provided that represents resources available in a cloud computing environment as hardware islands. A first compute cluster is registered with a first hardware island. A second compute cluster is registered with a second hardware island. A partnership is established between the first and second compute clusters. Based on the partnership, a workload processed by at least the first compute cluster is protected.

Abstract: A flange flush tool includes an outer tube having a first end and a second end, the first end configured to engage the flange, and a shield tube within the outer tube. A channel is defined between an outer surface of the shield tube and an inner surface of the outer tube. The shield tube is configured to move longitudinally within the outer tube.

Abstract: A video gaming system includes a motherboard with video display output, a USB and video switching board and a single board computer. The single board computer connects to the front panel power and reset switches, the switching board and the motherboard power switch input. Upon user input to the software program running on the single board computer, a limitations database is accessed. If time is allowed, the program powers the motherboard and switches the USB keyboard and video outputs to the motherboard. During the last minutes of allowed time, the program periodically flashes the display warning the user and, through power and reset switch presses, a time extension can be requested. If allowed, according to the database, use time is extended by the predefined setting. Otherwise time runs out normally and the motherboard is powered off and the USB and video circuits switched back to the single board computer.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selectivity for MCT4 over MCT1.

Abstract: A method for configuring a process control system includes coupling an I/O module to a PLC coupled to field devices. For each field device, the PLC has registers storing data of values associated with the field device. The PLC is configured such that each field device is associated with a PLC control tag, and each control tag is associated with tag parameters corresponding to the registers for the field device. The method includes configuring the I/O module to associate the tag parameters with corresponding controller parameters such that, for each control tag, there is a set of controller parameters associated with the tag parameters for the control tag. The method includes instantiating an integration object and associating the integration object with one of the control tags.

Abstract: A gaming machine configured to play one of a plurality of games. The gaming machine includes a display that has a first display area to display a carousel of first representations of a number of the games, and a second display area to display a matrix of second representations of the number of the games. A game controller controls the first display area to display the carousel and the second display area to display the matrix. In response to having received a player input at one display area of the first display area and the second display area, the game controller controls the one display area to highlight one representation in the one display area and highlights a corresponding another one representation in another one of the first display area and the second display area.

Abstract: This disclosure is directed at least partly to a kiosk that provides high speed data transfer of content to a user device associated with the user. The kiosk may be located in frequently visited locations such as travel terminals or public spaces. The kiosks may provide instructions to users about how to receive some of the content on user devices via a high speed data transfer. The kiosk may detect and prepare a user device for receipt of electronic content by wirelessly exchanging information with the user device, such as consent information, memory allocation information, and/or other relevant data. The high speed data transfer may use high speed data transfer protocols that enable download of full-length movies in a matter of a few seconds.

Abstract: A feeder is disclosed for dissolving a chemical and mixing it with a liquid. The feeder includes a hopper adapted to hold the chemical, a nozzle located in the hopper, and a supply of the liquid to the nozzle to dissolve the chemical on contact with the liquid from the nozzle to form a solution. A solution basin is disposed under the hopper and a drain is provided from the hopper into the solution basin. An outlet from the solution basin has an outlet valve which opens when a solution level in the solution basin rises.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.

Abstract: A cloud object model represents resources available in a cloud computing environment as hardware islands. A compute cluster is registered with a hardware island. The compute cluster is designated as being of a particular cluster type. An indication is received from a user to provision the compute cluster with storage. The object model is accessed to determine a cluster type of the cluster. The cluster is provisioned with storage of a type that corresponds to the cluster being of the particular type, where the storage provisioned includes one of replicated storage or non-replicated storage.