Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: A bonding endcap for use in connection with a bracket assembly for establishing an equipotential plane in a cable runway includes a spring clip and a bonding lug. The spring clip is made from an electrically conductive material and has two side walls that extend forward from a rear wall. The bonding lug is made from an electrically conductive material and includes a contact portion and a side arm extending at each side of the contact portion. The spring clip is positionable within a channel of a cable runway rail. The contact portion of the bonding lug is receivable between the side walls of the spring clip to deflect the side walls and establish an electrical bonding connection from the cable runway rail, through the spring clip, and to the bonding lug.

Abstract: A system for an automated cabin-divider door for an aircraft includes a door, a motor for moving the door to an open position, a limit switch configured to detect when the door is in a fully open position and to stop the motor, and electronics coupling the motor and the limit switch to an avionics system. The avionics system determines when the door is to be opened and provides a signal to the motor for moving the door to the fully open position. A method for automatically opening the cabin-divider door includes determining whether the aircraft is on the ground or in flight, determining whether the aircraft is taxiing, and determining whether the aircraft is in a final phase of approach. When the aircraft is taxiing or in the final phase of approach, the method includes sending a command signal to the motor for opening the cabin-divider door.

Abstract: The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: A computer-implemented medical visualization method includes identifying a three-dimensional model of an anatomical item of a particular mammal; displaying a moving animation of the three-dimensional model, the moving animation created from multiple frames from imaging of the anatomical item over a short time period to capture movement of the anatomical item; displaying one or more non-moving views of the three-dimensional model while the moving animation is being displayed; and in response to receiving inputs from a user, changing the displayed moving animation and the one or more non-moving views automatically in coordination with each other.

Abstract: A computer-implemented method for medical device modeling includes accessing an electronic definition for a model of a three-dimensional item and an electronic definition of a three-dimensional spline relating to an internal anatomical volume; determining, with a computer-based finite element analysis system and using the electronic definitions, stresses created by the three-dimensional item along the three-dimensional spline, for different points along the three-dimensional spline; and displaying stress data generated by the finite element analysis system with a visualization system, the display of the stress data indicating levels of stress on portions of the three-dimensional item at particular locations along the three-dimensional spline.

Abstract: Embodiments herein relate to distributed interactive medical visualization systems including user interface features and related methods. In an embodiment, a distributed interactive medical visualization system is included. The system can include a first video processing circuit, a first central processing circuit, a first communications circuit, and a first user-interface generated by the first video processing circuit. The first user interface can include a three-dimensional model of at least a portion of a subject's anatomy from a first perspective, the first perspective configured to be controlled by a first user. One or more graphical representations of one or more other users who are viewing the same three-dimensional model can also be included, wherein each of the one or more graphical representations identify individual users amongst the one or more other users. Other embodiments are also included herein.

Abstract: Compositions, methods and kits for the reduction of protein aggregation are provided. Further compositions, methods and kits are also provided for the treatment of diseases associated with protein aggregation, particularly polyglutamine disease, including Huntington's disease.

Abstract: Embodiments herein relate to distributed interactive medical visualization systems with primary/secondary interaction features and related methods. In an embodiment, a distributed interactive medical visualization system is included. The system can include a first video processing circuit and a first central processing circuit in communication with the first video processing circuit. The system can also include a first communications circuit. The system can also include a primary user interface generated by the first video processing circuit. The primary user interface can include a three-dimensional model of at least a portion of a subject's anatomy from a first perspective, the first perspective configured to be controlled by a primary user. The primary user interface can include a command interface object, wherein engagement can cause a secondary user interface to begin mirroring the perspective of the primary user on the three-dimensional model of the subject's anatomy.

Abstract: Embodiments herein relate to distributed interactive medical visualization systems including user interface features and related methods. In an embodiment, a distributed interactive medical visualization system is included having a first video processing circuit, a first central processing circuit in communication with the first video processing circuit, a first communications circuit in communication with the first central processing circuit, and a first user interface generated by the first video processing circuit. The first user interface can include a three-dimensional model of at least a portion of a subject's anatomy from a first perspective, the first perspective configured to be controlled by a first user. The first user interface can further include one or more user representations representing one or more other users, the user representations superimposed within the three-dimensional model, wherein each of the one or more user representations are visually distinct from one another.

Abstract: A computerized communications system for remotely controlling various color-changing lighting scenes on color-changing lighting fixtures at a premises. The color-changing lighting systems at the remote premises are used to communicate emergency information such as the existence and type of an emergency.

Abstract: The RC-LED Snubber Capacitive Voltage Nullification Circuit can aid in preventing the influence of capacitive voltages, particularly when applied with metering applications in the course of determining the wiring polarity. The use of this circuit can prevent false Correct Wiring conditions and will enhance reliability for other meters that rely on proper wiring for accurate results.

Abstract: The present disclosure provides a system and method for generating a biological mesh. In one embodiment, the biological mesh comprises one or more heat shock protein domains, where the one or more heat shock protein domains comprise at least a portion of a C-terminus of a Dictyostelium discoideum Hsp48 protein. The biological mesh further comprises a polymeric material having a negative charge, the polymeric material comprising polyphosphate having a number of monomer units [PO3?]n, wherein n is greater than 100.

Abstract: Scanners, methods, and computer storage media having computer-executable instructions embodied thereon that process variable sized objects with high package pitch on a moving conveyor belt are provided. The scanners are laser scanners that include at least two laser diodes, sensors, and field programmable gate arrays processors. The at least two laser diodes have different focuses. Each diode generates a laser beam when excited by an activation signal and an appropriate modulation. The sensors within the laser scanner device measure light reflected from a target on the objects. The processors toggle activation among the at least two laser diodes based on measurements sensed from the light reflected from the target.

Abstract: A computerized communications system for remotely controlling various color-changing lighting scenes on color-changing lighting fixtures at a premises. The color-changing lighting systems at the remote premises are used to communicate emergency information such as the existence and type of an emergency.

Abstract: A computer-implemented method for medical device modeling includes accessing an electronic definition for a model of a three-dimensional item and an electronic definition of a three-dimensional spline relating to an internal anatomical volume; determining, with a computer-based finite element analysis system and using the electronic definitions, stresses created by the three-dimensional item along the three-dimensional spline, for different points along the three-dimensional spline; and displaying stress data generated by the finite element analysis system with a visualization system, the display of the stress data indicating levels of stress on portions of the three-dimensional item at particular locations along the three-dimensional spline.