Abstract: The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical formula described by structural formula (II), wherein; R1 is independently selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, —(R9—CO—O—R10—O—CO—R9)—, CH R11—O—CO—R12—COOCR11— and combinations thereof; R3 and R4 in a single co-monomer m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), CH2OH, —CH(OH)CH3, —(CH2)4NH3+, ˜(CH2)3NHC(?NH2+)NH2, —CH2COOH, (CH2)COOH, —CH2—CO—NH2—CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, formula (a), HO-P-Ph-CH2—, (CH3)2—CH—, Ph- NH—, NH—(CH2)3—C—, NH—CH?N—CH?C—CH2—.

Abstract: Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface.

Abstract: A porous, water-absorbing fleece is made from crosslinkable biocompatible and biodegradable macromers. A solution of the macromers is frozen and vacuum-dried through lyophilization. The “fleece” formed by lyophilization is then crosslinked, for example by heat and/or an initiator of crosslinking. The resulting crosslinked material is highly water absorbent, readily swelling to at least its size before lyophilization, but retains macroporosity as well as the microporosity of a gel. Porosity and strength of the fleece can be controlled by initial polymer concentration and extent of crosslinking. The fleece materials can be used in different embodiments for applications in medicine and tissue engineering.

Abstract: Bioartificial organ storage and transport apparatus having a media storage container. The apparatus is designed to securely maintain a bioartificial organ within the container in a sealed environment. The apparatus may also allow for gas exchange and media exchange to ensure the viability of the bioartificial organ. In addition, the apparatus may use a secondary container and cap, designed to allow access to the media storage container and allow for gas exchange and media exchange.

Abstract: High molecular weight caprolactone polymers are coated on surgical sutures to improve suture properties such as smooth surface, single knot slipdown, two throw knot slipdown for repositioning, and three throw knot security.