Patents by Inventor Kenneth Newlander

Kenneth Newlander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fab I inhibitors
    Patent number: 6503903
    Abstract: Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections: wherein: R1 is H, C1-6alkyl or Ar—C0-6alkyl; R2 is H, C1-6alkyl, Ar—C0-6alkyl, HO—(CH2)n— or R′OC(O)—(CH2)n—; R3 is A—C0-4alkyl, A—C2-4alkenyl, A—C2-4alkynyl, A—C3-4oxoalkenyl, A—C3-4oxoalkynyl, A—C1-4aminoalkyl, A—C3-4aminoalkenyl, A—C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R10 or R7; R5 is H, C1-6alkyl, Ar—C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R7 is —COR8, —COCR′2R9, —C(S)R8, —S(O)kOR′, —S(O)kNR′R″, —PO(OR′), —PO(OR′)2, —B(OR′)2, —NO2, or tetrazolyl; R8 is —OR′, —NR′R″, —NR′SO2R′, —NR′OR′, or —OCR′
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: January 7, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: William H. Miller, Kenneth A. Newlander, Mark A. Seefeld
  • Silyl linker for solid phase organic synthesis of aryl-containing molecules
    Patent number: 6127489
    Abstract: This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: October 3, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Kenneth A. Newlander, Michael L. Moore
  • HIV protease inhibitors
    Patent number: 5438118
    Abstract: Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propiony l-valinyl-valinyl methyl ester.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: August 1, 1995
    Assignee: SmithKline Beechman Corp.
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Kenneth A. Newlander
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4908475
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 13, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4810778
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • 1,6-dicarba-vasopressin compounds
    Patent number: 4760052
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: July 26, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim