Patents by Inventor Kenneth P. Clapp
Kenneth P. Clapp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10767154Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.Type: GrantFiled: April 14, 2016Date of Patent: September 8, 2020Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard L. Damren, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Parrish M. Galliher, Kenneth P Clapp, Peter A. Mitchell
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Publication number: 20180237736Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bio culture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant.Type: ApplicationFiled: April 17, 2018Publication date: August 23, 2018Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: COLIN TUOHEY, TED DELOGGIO, THOMAS ERDENBERGER, KENNETH P. CLAPP, RICHARD DAMREN, PARRISH M. GALLIHER, PATRICK GUERTIN, JIYOUNG LEE, MICHAEL FISHER
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Patent number: 9969965Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.Type: GrantFiled: January 11, 2012Date of Patent: May 15, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
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Publication number: 20160230138Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.Type: ApplicationFiled: April 14, 2016Publication date: August 11, 2016Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD L. DAMREN, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, PARRISH M. GALLIHER, KENNETH P. CLAPP, PETER A. MITCHELL
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Patent number: 9340763Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system can include a body configured to be disposed in the reactor system having an inner replaceable reactant container is disclosed. The body can further include at least one thermally conductive surface adapted to contact the inner replaceable reactant container to facilitate heat transfer. Furthermore, the heat exchange module can include a heat exchanger disposed within the module body and can include a fluid circulation path through which a heat exchange fluid can be circulated.Type: GrantFiled: December 3, 2012Date of Patent: May 17, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard L. Damren, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Parrish M. Galliher, Kenneth P. Clapp, Peter A. Mitchell
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Publication number: 20130288346Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.Type: ApplicationFiled: January 11, 2012Publication date: October 31, 2013Applicant: Xcellerex Inc.Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
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Patent number: 8186870Abstract: The invention relates to a device for agitating media (1), which are located on a platform (3). Said device consists of a housing (2) with an agitation mechanism, which is used to agitate the platform (3) and at least one sensor (4, 5), which is connected to a control unit (7) that is equipped with an electronic sensor system (6). According to the invention, the sensor(s) (4, 5) and the electronic sensor system (6) are located on the platform (3) and communicate in a wireless manner with the fixed control unit (7).Type: GrantFiled: October 18, 2005Date of Patent: May 29, 2012Assignee: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Stefan Obermann, Christian Schmelig, Len Goren, Kenneth P. Clapp
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Publication number: 20090225626Abstract: The invention relates to a device for agitating media (1), which are located on a platform (3). Said device consists of a housing (2) with an agitation mechanism, which is used to agitate the platform (3) and at least one sensor (4, 5), which is connected to a control unit (7) that is equipped with an electronic sensor system (6). According to the invention, the sensor(s) (4, 5) and the electronic sensor system (6) are located on the platform (3) and communicate in a wireless manner with the fixed control unit (7).Type: ApplicationFiled: October 18, 2005Publication date: September 10, 2009Applicant: Sartorius AGInventors: Reinhard Baumfalk, Stefan Obermann, Christian Schmelig, Len Goren, Kenneth P. Clapp