Patents by Inventor Kenneth P. Nephew

Kenneth P. Nephew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of lncRNA HOTAIR and related materials and methods
    Patent number: 10801024
    Abstract: Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding RNA HOTAIR. In certain embodiments, synthetic polynucleotide analogs capable of hybridizing with a target sequence domain of HOTAIR are provided. The synthetic polynucleotide analogs can be formulated into a pharmaceutical composition for treating a subject having or at risk of having a condition characterized by HOTAIR overexpression. In certain embodiments, the pharmaceutical composition can resensitize a subject to a chemotherapeutic agent. Other embodiments concern uses for HOTAIR-targeting synthetic polynucleotide analogs, including methods for determining HOTAIR expression in a sample.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 13, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Ali Rayet Ozes, Kenneth P. Nephew
  • INHIBITION OF LNCRNA HOTAIR AND RELATED MATERIALS AND METHODS
    Publication number: 20180148720
    Abstract: Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding RNA HOTAIR. In certain embodiments, synthetic polynucleotide analogs capable of hybridizing with a target sequence domain of HOTAIR are provided. The synthetic polynucleotide analogs can be formulated into a pharmaceutical composition for treating a subject having or at risk of having a condition characterized by HOTAIR overexpression. In certain embodiments, the pharmaceutical composition can resensitize a subject to a chemotherapeutic agent. Other embodiments concern uses for HOTAIR-targeting synthetic polynucleotide analogs, including methods for determining HOTAIR expression in a sample.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 31, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Ali Rayet Ozes, Kenneth P. Nephew