Patents by Inventor Kenneth P. Shephard

Kenneth P. Shephard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conversion of a delta16-steroid to a delta17(20)-20-silyl ether
    Patent number: 4975536
    Abstract: The present invention is a process for conversion of .DELTA..sup.16 -steroids (I) ##STR1## to the corresponding .DELTA..sup.17(20) -20-silyl ether (III) ##STR2## by reaction with (1) a preformed copper hydride or a metal hydride reducing agent in the presence of a copper species and (2) a silylating agent. The .DELTA..sup.17(20) -20-silyl ether (III) are useful intermediates in the preparation of steroids useful as pharmaceuticals.
    Type: Grant
    Filed: June 2, 1989
    Date of Patent: December 4, 1990
    Assignee: The Upjohn Company
    Inventor: Kenneth P. Shephard
  • Process for producing 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroids
    Patent number: 4340538
    Abstract: Two processes are disclosed (one-pot and two-pot) for the transformation of a 6.beta.-fluoro-.DELTA..sup.1,4 -3-keto steroid (IV) to a 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroid (VI). These processes permit the introduction of a fluorine atom at the 6.alpha. position of a .DELTA..sup.1,4 -3-keto steroid where previously the .DELTA..sup.1 double bond could not be introduced until after the 6.alpha.-fluorine atom was present. The 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroids (VI) are intermediates useful in the production of pharmacologically active steroids.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: July 20, 1982
    Assignee: The Upjohn Company
    Inventor: Kenneth P. Shephard
  • Epoxide process
    Patent number: 4189430
    Abstract: 11.beta.,21-Dihydroxypregna-1,4,17(20)-triene-3-one 21-acetate (0) is epoxidized, followed by ring opening and hydrolysis to give 11.beta.,20,21-trihydroxypregna-1,4,16-triene-3-one 21-acetate (III), an intermediate in the synthesis of betamethasone, in improved yields.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: February 19, 1980
    Assignee: The Upjohn Company
    Inventor: Kenneth P. Shephard
  • Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
    Patent number: 4102907
    Abstract: The present invention discloses a process for the production of -androsta-4,9(11)-diene-3,17-dione-type compounds from 9.alpha.-hydroxyandrostenedione-type compounds by forming a sulfinate ester at C.sub.9 followed by desulfination.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: July 25, 1978
    Assignee: The Upjohn Company
    Inventor: Kenneth P. Shephard