Patents by Inventor Kenneth Phillips

Kenneth Phillips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240012009
    Abstract: Methods of assessing, monitoring and/or predicting clinical disease activity, treatment response, disease progression, and/or active repair for chronic inflammatory disease such as axial spondyloarthritis are provided based on the level and/or pattern of LCN2, LCN2-MMP9 and/or OSM.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 11, 2024
    Inventors: Florence Wing Ling Tsui, Aifeng Lin, Kenneth Phillip Henry Pritzker, Robert Davies Inman
  • Patent number: 11858699
    Abstract: A dispensing closure (40) for use with a container (44) includes a body (54) having a dispensing spout (72) with an interior surface (80) that defines at least a portion of a passage (132) for communicating with the container interior to permit the flow of a fluent substance through the body (54). The dispensing closure (40) includes a closing element (56) attached to the body (54). The closing element (56) defines a transverse cover (130) having a closed position relative to the body (54) and an actuated, open position relative to the body (54). The transverse cover (130) has an outwardly projecting toggle tab (58) for being engaged by a user to move the transverse cover (130) from the closed position to the actuated, open position. The transverse cover (130) further has a flexible, resilient cantilevered sealing portion (142) that seals against the interior surface (80) of the dispensing spout (72) with the transverse cover (130) located in the closed position.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: January 2, 2024
    Assignee: AptarGroup, Inc.
    Inventors: Curt Prusko, Kenneth Phillips, Timothy Spiegelhoff
  • Publication number: 20230358219
    Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.
    Type: Application
    Filed: July 20, 2023
    Publication date: November 9, 2023
    Inventors: Daniel ALLIS, Ian MCLAUGHLIN, Kenneth Phillips
  • Patent number: 11746765
    Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: September 5, 2023
    Assignee: INSULET CORPORATION
    Inventors: Daniel Allis, Ian McLaughlin, Kenneth Phillips
  • Patent number: 11724027
    Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: August 15, 2023
    Assignee: INSULET CORPORATION
    Inventors: Daniel Allis, Kenneth Phillips, Jacob Anthony Coumans
  • Publication number: 20230005569
    Abstract: The present disclosure relates to assessment of genetic variation, and in particular to techniques for detection of chromosomal and sub-chromosomal copy number variations. In one aspect, a computer-implemented method is provided for detecting a presence or absence of copy number variation in a target sample. The method includes obtaining sequencing data for a plurality of samples, determining a first normalized coverage for each segment/element in each of the samples according to the sequencing data, determining a second normalized coverage, including a copy number, for each segment/element in each of the samples according to the first normalized coverage, classifying the copy number for each segment/element in a target set in the target sample based on rule-based approaches, machine learning based approaches, or a combination thereof, and outputting a presence or absence of a copy number variation for each segment/element in the target set in the target sample according to the classification.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 5, 2023
    Inventors: Qiandong Zeng, Winnie Xin, Neil Russell, Chen Xu, Kenneth Phillips
  • Patent number: 11458250
    Abstract: Reservoir systems with improved wake up and fill volume detection techniques are provided. An example reservoir system may include a flexible reservoir and electrical components for detecting fill volume of the flexible reservoir without adversely affecting performance of the flexible reservoir when receiving or dispensing a liquid drug.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: October 4, 2022
    Assignee: INSULET CORPORATION
    Inventors: Kenneth Phillips, Steven Cardinali, David Nazzaro
  • Publication number: 20220163024
    Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.
    Type: Application
    Filed: February 8, 2022
    Publication date: May 26, 2022
    Inventors: Daniel ALLIS, Ian MCLAUGHLIN, Kenneth Phillips
  • Patent number: 11280327
    Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: March 22, 2022
    Assignee: INSULET CORPORATION
    Inventors: Daniel Allis, Ian McLaughlin, Kenneth Phillips
  • Publication number: 20210047086
    Abstract: A dispensing closure (40) for use with a container (44) includes a body (54) having a dispensing spout (72) with an interior surface (80) that defines at least a portion of a passage (132) for communicating with the container interior to permit the flow of a fluent substance through the body (54). The dispensing closure (40) includes a closing element (56) attached to the body (54). The closing element (56) defines a transverse cover (130) having a closed position relative to the body (54) and an actuated, open position relative to the body (54). The transverse cover (130) has an outwardly projecting toggle tab (58) for being engaged by a user to move the transverse cover (130) from the closed position to the actuated, open position. The transverse cover (130) further has a flexible, resilient cantilevered sealing portion (142) that seals against the interior surface (80) of the dispensing spout (72) with the transverse cover (130) located in the closed position.
    Type: Application
    Filed: February 9, 2018
    Publication date: February 18, 2021
    Inventors: Curt Prusko, Kenneth Phillips, Timothy Spiegelhoff
  • Patent number: 10765807
    Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: September 8, 2020
    Assignee: INSULET CORPORATION
    Inventors: Daniel Allis, Kenneth Phillips, Jacob Anthony Coumans
  • Publication number: 20190040850
    Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.
    Type: Application
    Filed: August 3, 2018
    Publication date: February 7, 2019
    Inventors: Daniel ALLIS, Ian MCLAUGHLIN, Kenneth Phillips
  • Publication number: 20180228282
    Abstract: A storage device that has a wall-mounted configuration and a freestanding configuration is provided and includes a first vertical support with one or more horizontal support members pivotably attached at intervals to the first vertical support, and includes a plurality of second vertical supports hingeably attached to the first vertical support on a first end of the vertical support, wherein the first vertical support and the second vertical supports can be collapsed together to form a wall-mountable vertical support that can be releasably attached to a wall-mounted bracket.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 16, 2018
    Inventors: Kevin Phillips, Kenneth Phillips
  • Patent number: 10039379
    Abstract: A storage device that has a wall-mounted configuration and a freestanding configuration is provided and includes a first vertical support with one or more horizontal support members pivotably attached at intervals to the first vertical support, and includes a plurality of second vertical supports hingeably attached to the first vertical support on a first end of the vertical support, wherein the first vertical support and the second vertical supports can be collapsed together to form a wall-mountable vertical support that can be releasably attached to a wall-mounted bracket.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: August 7, 2018
    Inventors: Kevin Phillips, Kenneth Phillips
  • Patent number: 9815599
    Abstract: A dispensing closure (40) for a container (44) of a fluent substance is disclosed. The closure includes a body (54) having an inlet portion (68) defining an inlet flow passage (74) for receiving the fluent substance from the container (44) and an elongate outlet portion (70) defining an outlet flow passage (78) for discharging the fluent substance. The closure (40) further has a valve (56) located within the body (54), across the inlet flow passage (74) and spaced axially inwardly of outlet flow passage (78) to define a chamber (216). The valve (56) has a flexible, resilient valve head portion (160) that has confronting, openable portions (212) movable from a closed configuration to an open configuration when the valve head portion (160) is subjected to a pressure differential acting across the valve head portion (160).
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: November 14, 2017
    Assignee: AptarGroup, Inc.
    Inventors: Tim Spiegelhoff, Frederic Duquet, Kenneth Phillips, Curt Prusko
  • Publication number: 20070125836
    Abstract: An integrated, hand-held device combining optical bar-code reading means with RFID-transponder commissioning means includes an on-board processing means, such as a portable-data-terminal that releasably couples to the device and wireless communicates with a host or network computer and seamlessly integrates data communication to and from the optical reader means and the commissioning means. A rechargeable battery pack provides power to each component and a single trigger mechanism enables multi-modal operation based on sensed conditions. Blank or pre-encoded RFID-transponders are supplied by a replaceable cartridge.
    Type: Application
    Filed: October 17, 2006
    Publication date: June 7, 2007
    Inventors: Clarke McAllister, Michael Gurney, Michael Hadlock, Kenneth Phillips
  • Publication number: 20060090218
    Abstract: The present invention relates to methods to regulate gene expression in plants. In particular, manipulation of the expression in a plant cell of a nucleotide sequence encoding a polypeptide comprising a 3?-5? exonuclease domain is disclosed. More stable and predictable expression is thus obtained. The present invention also relates to method of increasing or decreasing post-transcriptional silencing. The invention further relates to novel nucleic acid molecules comprising nucleotide sequences encoding polypeptides comprising a 3?-5? exonuclease domain.
    Type: Application
    Filed: December 13, 2005
    Publication date: April 27, 2006
    Inventors: Joshua Levin, Kenneth Phillips, Gregory Budziszewski, Frederick Meins, Evgueni Glazov
  • Publication number: 20050112715
    Abstract: The present inventors have discovered that pectin esterase is essential for plant growth. Specifically, the inhibition of pectin esterase gene expression resulted in seedlings that were damaged, short, and stunted at a very early growth stage. Thus, pectin esterase can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit pectin esterase expression or activity, comprising: contacting a compound with a pectin esterase and detecting the presence and/or absence of binding between said compound and said pectin esterase, or detecting a decrease in pectin esterase expression or activity. The methods of the invention are useful for the identification of herbicides.
    Type: Application
    Filed: November 20, 2003
    Publication date: May 26, 2005
    Inventors: Adel Zayed, Robert Ascenzi, Douglas Boyes, Rao Mulpuri, Neil Hoffman, Keith Davis, Jorn Gorlach, Jeffrey Woessner, Carol Hamilton, Kenneth Phillips
  • Publication number: 20050100879
    Abstract: The present inventors have discovered that Flavanone 3-hydroxylase (“FHT”) is essential for plant growth. Specifically, the inhibition of FHT gene expression in plant seedlings results in small and chlorotic seedlings. Thus, FHT can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit FHT expression or activity. The present invention can be used to identify compounds having herbicide activity by contacting a compound with FHT and detecting the presence and/or absence of binding between the compound and the FHT, or alternatively, detecting a decrease in FHT expression or activity.
    Type: Application
    Filed: November 6, 2003
    Publication date: May 12, 2005
    Inventors: Keith Davis, Adel Zayed, Robert Ascenzi, Douglas Boyes, Neil Hoffman, Jorn Gorlach, Jeffrey Woessner, Carol Hamilton, Kenneth Phillips
  • Publication number: 20040265789
    Abstract: The present inventors have discovered that 3-oxo-5-alpha-steroid 4-dehydrogenase (DET2) is essential for plant growth. Specifically, the inhibition of DET2 gene expression in plant seedlings resulted in seedlings that are shorter than controls and chlorotic. Thus, DET2 can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit DET2 expression or activity, comprising: contacting a compound with a DET2 and detecting the presence and/or absence of binding between said compound and said DET2, or detecting a decrease in DET2 expression or activity. The methods of the invention are useful for the identification of herbicides.
    Type: Application
    Filed: November 20, 2003
    Publication date: December 30, 2004
    Inventors: Robert Ascenzi, Douglas Boyes, Neil Hoffman, Keith Davis, Adel Zayed, Rao Mulpuri, Jeffrey Woessner, Jorn Gorlach, Carol Hamilton, Kenneth Phillips