Abstract: Embodiments of apparatuses, systems, methods for monitoring wound pH are disclosed. In some embodiments, a wound dressing includes one or more optical sensors configured to measure a change in color of a pH-sensitive adhesive that changes color in response to changes in wound exudate pH. In some embodiments, the wound dressing may further comprise hydrophilic channels that direct wound exudate to a pH-sensitive material over the optical sensors. Such dressings may also be used in combination with a negative pressure wound therapy system.

Abstract: Embodiments of apparatuses and methods for determining an emplacement of sensors in a wound dressing are disclosed. In some embodiments, a wound dressing includes a plurality of sensors configured to measure wound or patient characteristics. One or more processors are configured to receive wound or patient characteristics data as well as emplacement data. The received data can be used to determine an emplacement of the plurality of sensors, the wound dressing, or a wound. The sensors can include a set of nanosensors. The wound dressing can include pH sensitive ink which can be utilized for determining a placement of the wound dressing and determining a pH associated with the wound. The wound dressing can be used in a negative pressure wound therapy system.

Abstract: In some embodiments, a wound monitoring and/or therapy apparatus includes a wound dressing configured to be positioned in contact with a wound, the wound dressing comprising one or more sensors configured to obtain measurement data of at least one of the wound or periwound. The apparatus can also include a controller configured to maintain a device clock indicative of a non-real time clock, receive measurement data obtained by the one or more sensors, and transmit measurement data to a remote computing device according to a security protocol, the security protocol comprising including the device clock associated with the measurement data in the transmission.

Abstract: A wound monitoring and/or therapy system can include a substantially stretchable substrate supporting a plurality of electronic components, including sensors, and a plurality of electronic connections that connect at least some of the electronic components. The electronic components can also include a circuit board supporting at least one controller configured to control at least some of the sensors, the circuit board configured to operate without failure when the substrate is flexed as a result of strain. A calibration track can be positioned on the substrate and connected to a monitoring circuit configured to measure a change in resistance of the calibration track indicative of resistance change of at least some of the plurality of electronic connections. The system can include a controller with a circuit board supporting a plurality of electrical components and an antenna configured to communicate with the substrate, the antenna at least partially enclosing the circuit board.

Abstract: The present disclosure relates to assessment of genetic variation, and in particular to techniques for detection of chromosomal and sub-chromosomal copy number variations. In one aspect, a computer-implemented method is provided for detecting a presence or absence of copy number variation in a target sample. The method includes obtaining sequencing data for a plurality of samples, determining a first normalized coverage for each segment/element in each of the samples according to the sequencing data, determining a second normalized coverage, including a copy number, for each segment/element in each of the samples according to the first normalized coverage, classifying the copy number for each segment/element in a target set in the target sample based on rule-based approaches, machine learning based approaches, or a combination thereof, and outputting a presence or absence of a copy number variation for each segment/element in the target set in the target sample according to the classification.

Abstract: Reservoir systems with improved wake up and fill volume detection techniques are provided. An example reservoir system may include a flexible reservoir and electrical components for detecting fill volume of the flexible reservoir without adversely affecting performance of the flexible reservoir when receiving or dispensing a liquid drug.

Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.

Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.

Abstract: A dispensing closure (40) for use with a container (44) includes a body (54) having a dispensing spout (72) with an interior surface (80) that defines at least a portion of a passage (132) for communicating with the container interior to permit the flow of a fluent substance through the body (54). The dispensing closure (40) includes a closing element (56) attached to the body (54). The closing element (56) defines a transverse cover (130) having a closed position relative to the body (54) and an actuated, open position relative to the body (54). The transverse cover (130) has an outwardly projecting toggle tab (58) for being engaged by a user to move the transverse cover (130) from the closed position to the actuated, open position. The transverse cover (130) further has a flexible, resilient cantilevered sealing portion (142) that seals against the interior surface (80) of the dispensing spout (72) with the transverse cover (130) located in the closed position.

Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.

Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.

Abstract: Reservoir systems with improved wake up and fill volume detection techniques are provided. An example reservoir system may include a flexible reservoir and electrical components for detecting fill volume of the flexible reservoir without adversely affecting performance of the flexible reservoir when receiving or dispensing a liquid drug.

Abstract: A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.

Abstract: A storage device that has a wall-mounted configuration and a freestanding configuration is provided and includes a first vertical support with one or more horizontal support members pivotably attached at intervals to the first vertical support, and includes a plurality of second vertical supports hingeably attached to the first vertical support on a first end of the vertical support, wherein the first vertical support and the second vertical supports can be collapsed together to form a wall-mountable vertical support that can be releasably attached to a wall-mounted bracket.

Abstract: A storage device that has a wall-mounted configuration and a freestanding configuration is provided and includes a first vertical support with one or more horizontal support members pivotably attached at intervals to the first vertical support, and includes a plurality of second vertical supports hingeably attached to the first vertical support on a first end of the vertical support, wherein the first vertical support and the second vertical supports can be collapsed together to form a wall-mountable vertical support that can be releasably attached to a wall-mounted bracket.

Abstract: A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.

Abstract: A dispensing closure (40) for a container (44) of a fluent substance is disclosed. The closure includes a body (54) having an inlet portion (68) defining an inlet flow passage (74) for receiving the fluent substance from the container (44) and an elongate outlet portion (70) defining an outlet flow passage (78) for discharging the fluent substance. The closure (40) further has a valve (56) located within the body (54), across the inlet flow passage (74) and spaced axially inwardly of outlet flow passage (78) to define a chamber (216). The valve (56) has a flexible, resilient valve head portion (160) that has confronting, openable portions (212) movable from a closed configuration to an open configuration when the valve head portion (160) is subjected to a pressure differential acting across the valve head portion (160).

Abstract: A dispensing closure (40) for a container (44) of a fluent substance is disclosed. The closure includes a body (54) having an inlet portion (68) defining an inlet flow passage (74) for receiving the fluent substance from the container (44) and an elongate outlet portion (70) defining an outlet flow passage (78) for discharging the fluent substance. The closure (40) further has a valve (56) located within the body (54), across the inlet flow passage (74) and spaced axially inwardly of outlet flow passage (78) to define a chamber (216). The valve (56) has a flexible, resilient valve head portion (160) that has confronting, openable portions (212) movable from a closed configuration to an open configuration when the valve head portion (160) is subjected to a pressure differential acting across the valve head portion (160).

Abstract: A policyholder report may be obtained by an insurer from an insured through a series of questions presented by an automated, electronic system. The insured may access the system through a portal, such as a graphical user interface, which may ask the insured a dynamic series of account and/or risk-based questions at or near the expiration of an insurance policy term, and permit the insured to submit verification and supporting information through the portal. Based on the insured's responses to the questions and the information provided, the insurer may complete a review and/or audit, and determine an adjustment to the premium. Additionally, the system may permit the insured and the insurer to review the audit during all stages of completion, and may allow the insured to opt out of the electronic process at any time, or to dispute the results of the audit through the portal.

Abstract: An integrated, hand-held device combining optical bar-code reading means with RFID-transponder commissioning means includes an on-board processing means, such as a portable-data-terminal that releasably couples to the device and wireless communicates with a host or network computer and seamlessly integrates data communication to and from the optical reader means and the commissioning means. A rechargeable battery pack provides power to each component and a single trigger mechanism enables multi-modal operation based on sensed conditions. Blank or pre-encoded RFID-transponders are supplied by a replaceable cartridge.