Patents by Inventor Kenneth R. Crawford

Kenneth R. Crawford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240360934
    Abstract: In accordance with at least one aspect of this disclosure, a fastener free joining system, includes, a first tubular shell-type component having a first plurality of teeth defined in a first free end, each tooth extending along a respective tooth axis oblique to an axis of the first component by an angle ?. The first plurality of teeth is configured to engage with a plurality of complimentary teeth defined in a second free end of a second tubular shell-type component, such that, when engaged, the first plurality of teeth is configured to remain engaged with the plurality of complimentary teeth under axial load.
    Type: Application
    Filed: April 28, 2023
    Publication date: October 31, 2024
    Applicant: Goodrich Corporation
    Inventors: Mark R. Gurvich, Kevin P. Walsh, Michael Maynard, Kenneth C. Crawford
  • Patent number: 8431745
    Abstract: A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 30, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Kenneth R. Crawford, Eric D. Dowdy, Arnold Gutierrez, Richard P. Polniaszek, Richard Hung Chiu Yu
  • Publication number: 20120258935
    Abstract: A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed
    Type: Application
    Filed: February 21, 2012
    Publication date: October 11, 2012
    Applicant: Gilead Sciences, Inc.
    Inventors: Kenneth R. Crawford, Eric D. Dowdy, Arnold Gutierrez, Richard P. Polniaszek, Richard Hung Chiu Yu
  • Patent number: 8173623
    Abstract: A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: May 8, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Kenneth R. Crawford, Eric Dowdy, Arnold Gutierrez, Richard P. Polniaszek, Richard Hung Chiu Yu
  • Patent number: 8106035
    Abstract: The present invention provides novel D-ring and side-chain analogs of 1?,25-dihydroxyvitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1?,25-dihydroxyvitamin D3, for example, cell-proliferative disorders.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: January 31, 2012
    Assignee: Cytochroma Inc.
    Inventors: Gary H. Posner, Jae Kyoo Lee, Qiang Wang, Kenneth R. Crawford, Hong Woon Yang, Steven M. Silverman, Byung-Chul Suh, Jay A. White, Glenville Jones, Uttam Saha, Heung Bae Jeon
  • Publication number: 20110065631
    Abstract: A process for the synthesis of bisfuran intermediates of formula (0) useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. Furthermore disclosed is a HIV protease inhibitor of formula (IV) as well as various intermediates thereof.
    Type: Application
    Filed: March 29, 2007
    Publication date: March 17, 2011
    Applicant: Gilead Sciences, Inc
    Inventors: Kenneth R. Crawford, Eric D. Dowdy, Arnold Gutierrez, Richard Polniaszek, Richard H. Yu
  • Publication number: 20040224930
    Abstract: The present invention provides novel D-ring and side-chain analogs of 1&agr;,25-dihydroxyvitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1&agr;,25-dihydroxyvitamin D3, for example, cell-proliferative disorders.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 11, 2004
    Inventors: Gary H. Posner, Jae Kyoo Lee, Qiang Wang, Kenneth R. Crawford, Hong Woon Yang, Steven M. Silverman, Byung-Chul Suh, Jay A. White, Glenville Jones, Uttam Saha, Heung Bae Jeon
  • Publication number: 20030149005
    Abstract: The present invention provides novel C24-aryl sulfone analogs of 1&agr;,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1&agr;,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
    Type: Application
    Filed: August 22, 2002
    Publication date: August 7, 2003
    Inventors: Gary H. Posner, Kenneth R. Crawford, Hong Woon Yang, Jay A. White, Glenville Jones, Byung-Chul Suh, HeungBae Jeon, Mark Hatcher
  • Patent number: 6380408
    Abstract: Novel sulfur-containing analogs of 1&agr;,25-dihydroxy vitamin D3 are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1&agr;,3&bgr;-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 30, 2002
    Assignee: The Johns Hopkins University
    Inventors: Gary H. Posner, Jae-Kyoo Lee, Qiang Wang, Kenneth R. Crawford, Gyoonhee Han
  • Patent number: 5361497
    Abstract: A folding knife holder and method, whereby a folding knife can be safely carried in an elongate knife holder, comprising a housing member that has an elongate recess defined by a base surface, side surfaces and end surfaces, and sized and shaped to receive the knife in an orientation that is substantially parallel to the base surface, with the spine of the knife laying against the base. The margin of the walls of the housing member define an elongate orifice opening into the recess. The orifice is partially occluded at one end by a strike member. The strike member has a gap, wider than the knife blade. When the back of the knife blade is grasped and pulled in an outward direction, the knife blade will pass through the gap in the strike member and the strike member will blockingly engage the butt of the knife handle, thereby allowing the knife blade to be pivotably rotated into an open position.
    Type: Grant
    Filed: May 12, 1993
    Date of Patent: November 8, 1994
    Inventor: Kenneth R. Crawford