Abstract: Certain platinum co-ordination compounds, but not cisplatin, exhibit increased bioavailability when given by the oral route in combination with loperamide.

Abstract: Quinazoline derivatives of formula: ##STR1## wherein R represents: (1) a straight or branched chain unsaturated hydrocarbon group, or(2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R is a C.sub.1 hydrocarbon group; or saturated carbocyclic group; or group containing at least one heteroatom, the or each heteroatom being O, N or S when R contains a cyclic group; andn is O or an integer of 1-4;X or, when n is an integer of at least 2, each X independently, represents a halogeno, C.sub.1 -C.sub.4 alkyl, aryl or aralkyl group or a group including at least one heteroatom; andY represents a group of formula: ##STR2## wherein m.gtoreq.1 (poly-L-glutamates); and the pharmaceutically acceptable salts and esters thereof, which are suitable as anti-cancer agents.

Abstract: Quinazoline derivatives of formula: ##STR1## wherein R represents: (1) a straight or branched chain unsaturated hydrocarbon group, or(2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R is a C.sub.1 hydrocarbon group; or saturated carbocyclic group; or group containing at least one heteroatom, the or each heteroatom being O, N or S when R contains a cyclic group; andn is 0 or an integer of 1-4;X or, when n is an integer of at least 2, each Xindependently, represents a halogeno, C.sub.1 -C.sub.4 alkyl, aryl or aralkyl group or a group including at least one heteroatom; andY represents a group of formula: ##STR2## wherein m.gtoreq.1 (poly-L-glutamates); and the pharmaceutically acceptable salts and esters thereof, which are suitable as anti-cancer agents.