Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Abstract: A device includes an elongated strap, a latch structure connected to the strap and configured to receive and secure a portion of the strap within the latch structure when an end of the strap is inserted through an opening of the latch, and a clamping structure secured to the strap. The clamping structure includes a flexible ring member with two free ends that are separable from each other to define a gap between the two free ends and are further configured to be drawn toward each other such that one free end overlaps the other free end, and a locking mechanism that is operable by a user to selectively compress the ring member so as to secure a portion of at least one power cord within the ring member.

Abstract: A magnetic head cluster is provided along with a method of making a magnetic head cluster. The magnetic head cluster comprises a substrate having a plurality of magnetoresistive (MR) read and inductive magnetic write transducers and a plurality of terminals formed thereon. A plurality of lapping guides are also provided on the substrate between adjacent transducers.

Abstract: A magnetic head cluster is provided along with a method of making a magnetic head cluster. The magnetic head cluster comprises a substrate having a plurality of magnetoresistive (MR) read and inductive magnetic write transducers and a plurality of terminals formed thereon. A plurality of lapping guides are also provided on the substrate between adjacent transducers.

Abstract: A magnetic head cluster is provided along with a method of making a magnetic head cluster. The magnetic head cluster comprises a substrate having a plurality of magnetoresistive (MR) read and inductive magnetic write transducers and a plurality of terminals formed thereon. A plurality of lapping guides are also provided on the substrate between adjacent transducers.

Abstract: An improved life vest with an accompanying safety harness is comprised of a life vest body which body is provided with a pliable cushion member mountable about the torso of the wearer. An elongated flexible strap member is secured about the outer surface of the cushion member. One end portion of the strap member is provided with a slipping type buckle (such as a pair of D-rings). The opposite end portion of the strap member is supplied with a suitable connection member such as a hook. There can be further provided a stop member on the strap which limits the degree of constriction which can be achieved by the strap about the vest. Alternatively, the stop could be ommitted, and extra padding in the life vest body utilized to prevent injury to the wearer during constriction of the device.

Abstract: A coolant system for a machine tool is disclosed. Sockets on the machine tool are equipped with check valves biased to a closed position. When a tool is inserted into a socket, an actuating member opens the check valve to enable coolant to flow through a conduit in the tool to the cutting edge of the tool. Tools whose cutting edges do not require coolant are not equipped with the actuating member. In addition, a distributor is provided for use in the coolant system of a machine tool having a turret. The distributor is mounted on the turret and is coaxial with the axis of rotation of the turret. Coolant is piped into the center of a distributing member having an outlet on a cylindrical side surface. A receiving member has a cylindrical chamber in which the distributing member is rotatably disposed. The receiving member has a plurality of radially disposed passages which lead from the receiving member to the tool receiving sockets on the turret.

Abstract: An improved lock assembly is utilized to hold a tool in a socket of a machine tool. The lock assembly includes a carriage which is movable toward and away from the socket along a path extending perpendicular to a central axis of the socket. A retaining member is pivotally supported on the carriage. Movement of the carriage toward the socket moves the retaining member from a disengaged position in which it is spaced apart from a tool disposed in the socket to an engaged position in which the retaining member abuts the tool and presses it firmly into the socket. As the carriage moves toward the socket, the retaining member rotates relative to the carriage from the disengaged position in which it is disposed at an oblique angle to the central axis of the socket to the engaged position in which it is more closely parallel to the central axis of the socket.

Abstract: Process of metalating benzene containing alkyl, alkoxy or dialkylamino substituents, such as toluene, anisole and N,N-dimethyl-aniline, with an organolithium compound such as sec-butyllithium adducts with styrene, in the presence of a tertiary alkyl amine (containing no methyl groups) such as triethylamine, the ratio of lithium in said organolithium compound to the tertiary alkyl amine being 1 gram atom of the lithium to from about 0.25 to about 4 gram moles of the tertiary alkyl amine.