Patents by Inventor Kenneth S. Graham

Kenneth S. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VEGF antagonist formulations suitable for intravitreal administration
    Patent number: 7608261
    Abstract: Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has the amino acid sequence shown in SEQ ID NO:4.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: October 27, 2009
    Assignee: Regeneron Pharmacuticals, Inc.
    Inventors: Eric Furfine, Daniel Dix, Kenneth S. Graham, Kelly Frye
  • Method for C-terminal degradation of peptides and proteins
    Patent number: 5986071
    Abstract: A method for C-Terminal degradation of peptides and proteins involves forming a thiohydantoin derivative of the C-Terminal amino acid and then cleaving the derivatized amino acid by reaction with methoxide or methiolate ions.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: November 16, 1999
    Assignee: City of Hope
    Inventors: Kenneth S. Graham, John E. Shively