Patents by Inventor Kenneth S. Hirsch

Kenneth S. Hirsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-based detection and differentiation of disease states
    Publication number: 20080139402
    Abstract: The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
    Type: Application
    Filed: September 25, 2007
    Publication date: June 12, 2008
    Inventors: Norman J. Pressman, Kenneth S. Hirsch, Adrian Hirsch
  • Cell-based detection and differentiation of lung cancer
    Patent number: 6939670
    Abstract: The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: September 6, 2005
    Assignee: Monogen, Inc.
    Inventors: Norman J. Pressman, Adrian Hirsch, Kenneth S. Hirsch
  • Cell-based detection and differentiation of disease states
    Publication number: 20030199685
    Abstract: The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
    Type: Application
    Filed: March 12, 2002
    Publication date: October 23, 2003
    Applicant: Monogen, Inc.
    Inventors: Norman J. Pressman, Kenneth S. Hirsch, Adrian Hirsch
  • Cell-based detection and differentiation of disease states
    Publication number: 20030190602
    Abstract: The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
    Type: Application
    Filed: September 12, 2002
    Publication date: October 9, 2003
    Applicant: Monogen, Inc.
    Inventors: Norman J. Pressman, Kenneth S. Hirsch
  • Cell-based detection and differentiation of lung cancer
    Publication number: 20030104499
    Abstract: The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell-based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.
    Type: Application
    Filed: March 12, 2002
    Publication date: June 5, 2003
    Applicant: MONOGEN, INC.
    Inventors: Norman J. Pressman, Kenneth S. Hirsch, Adrian Hirsch
  • Methods and reagents for the identification and regulation of senescence-related genes
    Patent number: 5744300
    Abstract: Identification of senescence-related genes can be accomplished by comparing mRNA expression between young and senescent cells. Probes complementary to such genes can be used to detect senescent cells and distinguish between young and senescent cells as well as in screens to identify compounds that alter expression levels of senescence-related genes.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: April 28, 1998
    Assignee: Geron Corporation
    Inventors: Maarten H. K. Linskens, Kenneth S. Hirsch, Bryant Villeponteau, Junli Feng, Walter Funk, Michael David West
  • Benzo ?F! quinolinones
    Patent number: 5670512
    Abstract: This invention relates to hexa- and octaahydrobenzo?f!quinolin-3-ones, pharmaceutical formulations containing those compounds and methods of their use as steroid 5.alpha.-reductase inhibitors.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: September 23, 1997
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Kenneth S. Hirsch, Charles D. Jones, David E. Lawhorn, Loretta A. McQuaid, Leland O. Weigel
  • Benzo(F)quinolinones
    Patent number: 5541190
    Abstract: This invention relates to hexa- and octahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds and methods of their use as steroid 5.alpha.-reductase inhibitors.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 30, 1996
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Kenneth S. Hirsch, Charles D. Jones, David E. Lawhorn, Loretta A. McQuaid, Leland O. Weigel
  • Benzo[F]quinolinones
    Patent number: 5334767
    Abstract: This invention relates to hexa- and octahydrobenzo [f]quinolin-3-ones, pharmaceutical formulations containing those compounds and methods of their use as steroid 5.alpha.-reductase inhibitors.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: August 2, 1994
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Kenneth S. Hirsch, Charles D. Jones, David E. Lawhorn, Loretta A. McQuaid, Leland O. Weigel
  • Hexahydrobenzo[f]quinolinones
    Patent number: 5250539
    Abstract: The invention relates to 1,2,3,4,5,6-hexahydrobenzo[f]quinolin-3-ones, pharmaceutical formulations containing those compounds, and their use as steroid 5.alpha.-reductase inhibitors.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: October 5, 1993
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones
  • Aromatase inhibitors from azoles
    Patent number: 4845227
    Abstract: This invention provides azole derivatives, their pharmaceutical formulations, and their use in methods of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
    Type: Grant
    Filed: August 15, 1988
    Date of Patent: July 4, 1989
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones
  • Aromatase inhibitors
    Patent number: 4801594
    Abstract: This invention provides azole derivatives, their pharmaceutical formulations, and their use in methods of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones
  • Method of inhibiting aromatase
    Patent number: 4774251
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain amine derivatives.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: September 27, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor
  • Indenopyrimidine aromatase inhibitors
    Patent number: 4769378
    Abstract: Certain 5-phenyl-5H-indeno[1,2-d]pyrimidines, their pharmaceutical formulations, and their use in methods for inhibiting aromatase and treating or preventing estrogen-dependent diseases.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: September 6, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, C. David Jones, Eriks V. Krumkalns, Donald G. Saunders
  • Method of inhibiting aromatase
    Patent number: 4767770
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain amine derivatives. Pharmaceutical formulations of the compounds are also provided.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 30, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor
  • Method of inhibiting aromatase
    Patent number: 4766140
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals which comprises administering certain imidazole derivatives.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 23, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones, Harold M. Taylor
  • Method of inhibiting aromatase
    Patent number: 4764376
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain pyrazine derivatives. Pharmaceutical formulations of the pyrazine derivatives are also provided.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: August 16, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor
  • Aromatase inhibitors
    Patent number: 4762836
    Abstract: This invention provides for a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain pyrimidine derivatives. Pharmaceutical formulations of the pyrimidine derivatives are also provided.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: August 9, 1988
    Assignee: Eli Lilly and Company
    Inventor: Kenneth S. Hirsch
  • Method of inhibiting aromatase
    Patent number: 4757082
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain azole derivatives.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 12, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor
  • Method of inhibiting aromatase
    Patent number: 4757076
    Abstract: This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain pyridine derivatives.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 12, 1988
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Harold M. Taylor