Abstract: Methods are provided for treating or preventing human immunodeficiency virus-1 (HIV-1) or human immunodeficiency virus-2 (HIV-2) in a virologically suppressed patient in need thereof comprising switching the patient from an antiretroviral treatment regimen comprising at least three antiretroviral agents to a treatment regimen comprising only two antiretroviral agents. In one aspect the two treatment regimen consists of dolutegravir, rilpivirine and at least one pharmaceutically acceptable excipient, diluent or carrier. In another aspect of the invention, there is provided a multilayer tablet comprising dolutegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for identifying an operating characteristic in a commodity transport network model may involve displaying a scaled map of a region; receiving flow information corresponding to a user-selected object displayed on the map; and, using the flow information, identifying the operating characteristic. Systems and methods for representing an event in a display of a planning project analysis computer system may involve representing on the display a scaled map of a region; and displaying on the display an indication of the event. The indication may designate a position in the display that corresponds a location of the event.