Abstract: In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1.

Abstract: A method for making a jelly confectionery comprising preparing a liquid jelly confectionery composition comprising bulk sweetener and a hydrocolloid gelling agent, cooking the liquid jelly confectionery composition, and depositing the liquid jelly confectionery composition into a mold, wherein the viscosity of the liquid jelly confectionery composition is temporarily modified for a period of time commencing prior to deposition of the liquid jelly confectionery into a mold.

Abstract: A method is provided for verifying integrity of a recirculation valve in a recirculation line of an LNG dispenser. The method includes: closing the recirculation valve and a fill valve in a supply line that supplies LNG; monitoring a mass of the LNG flowing through the recirculation line to ensure that the mass flowing therethrough is less than an acceptable threshold; and aborting any pending sales if the mass of the LNG flowing therethrough is not less than the acceptable threshold. According to another embodiment, a method is provided for verifying integrity of a vent valve in an LNG dispenser. The method includes: closing the vent valve and opening a fill valve in a supply line that supplies LNG; monitoring the pressure of the LNG within the fill hose to ensure that the pressure remains steady; and aborting any pending sales if the pressure does not remain steady.

Abstract: According to one embodiment, a CNG dispenser is provided that includes a user-actuatable button for allowing selection of a pressure to which to fill a vehicle tank with CNG, and a controller for opening a high pressure fill valve to dispense high pressure CNG into the vehicle tank while monitoring the pressure of the vehicle tank until the pressure reaches the user-selected pressure. According to another embodiment, the controller is operable in a selected one of two modes of operation. The two modes of operation include a one-pressure bank operation mode in which only the input of a high pressure fill valve is coupled to a CNG supply line, and a three-pressure bank operation mode in which the inputs of each of three fill valves are coupled to respective CNG supply lines. A graphic fuel gage may be provided on the dispenser payment terminal screen.

Abstract: Fuel dispensers are provided that include a controller that controls sales transactions, The controller allows a user to dispense more than one fuel type in a single sales transaction. The types of fuel may include various combinations and subcombinations of liquid natural gas (LNG), compressed natural gas (CNG), gasoline, diesel fuel, and diesel exhaust fluid (DEF). A display on the dispensers may be used to display training images. The dispensers may use a novel communication protocol for communicating with a control console of a fuel farm.

Abstract: The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.

Abstract: A method for making a jelly confectionery comprising preparing a liquid jelly confectionery composition comprising bulk sweetener and a hydrocolloid gelling agent, cooking the liquid jelly confectionery composition, and depositing the liquid jelly confectionery composition into a mould, wherein the viscosity of the liquid jelly confectionery composition is temporarily modified for a period of time commencing prior to deposition of the liquid jelly confectionery into a mould.

Abstract: An apparatus that allows for safe and secure transport of a tank, canister, container or cylinder in the upright position on the seat in a vehicle, using the three point seat belt mechanism provided in the vehicle. The primary use was directed toward transportation of a 20 pound propane tank. An apparatus consisting of a body and a bracket, attachment or mechanism that holds the seats belts in place around the tank or cylinder. The body comes into contact with the tank and the brackets, attachments or mechanism that are a part of the body, allow for the three point seat belt straps to be placed in a proper position to hold the tank against the car seat in the car. There is also a retaining strap that goes around the value area of the tank to hold it in place.

Abstract: The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.

Abstract: The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.

Abstract: This invention concerns humanized antibodies specific for the lymphotoxin beta receptor (LT-?-R), cell lines that produce these antibodies, immunochemicals made from the antibodies, and diagnostic methods that use the antibodies. The invention also relates to the use of the antibodies alone or in combination with chemotherapeutic agent(s) in therapeutic methods.

Abstract: The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies.

Abstract: This invention concerns humanized antibodies specific for the lymphotoxin beta receptor (LT-?-R), cell lines that produce these antibodies, immunochemicals made from the antibodies, and diagnostic methods that use the antibodies. The invention also relates to the use of the antibodies alone or in combination with chemotherapeutic agent(s) in therapeutic methods.

Abstract: Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.

Abstract: A container assembly for transporting hazardous or corrosive material wherein a bottle containing the material is cushioned against breakage and the container is protected against leakage. The assembly includes an outer metal container with a bottle disposed within but partially or entirely out of contact with the container. The bottle is separated from the container by a plurality of separate, removable and repeatedly moldable and shapable cushion elements. Each cushion element is filled with a free flowing particulate solid material. There are individual cushion elements below the bottle, above the bottle and wrapped around the body portion of the bottle, respectively. Thereby, the cushion elements can fill essentially the entire space between the bottle and the metal container, providing mechanical support and absorption capability in case of leakage or breakage. The cushion elements can be quilted to provide pockets which prevent uneven distribution of the absorbent material.

Abstract: A quilt and hand puppet combination comprising a sheet of material having top and bottom surfaces, a scene on the top surface of the sheet including a doorway, and at least one puppet attached to the sheet at the base of the doorway in position to be part of the scene. A hole in the sheet aligned with the puppet gives access to the interior of the puppet from the bottom surface of the sheet to operate the puppet. A pocket sized to receive the puppet may be integrated into the scene, preferably over the doorway, to give the appearance that the puppet enters and leaves the scene.

Abstract: A tamper evident mechanism for a bottle and closure assembly. The bottle and closure each have engaging means adapted for engagement with each other upon clockwise rotation of the closure means and for becoming interlocked against counterclockwise rotation to prevent removal of the closure. A tear tab and associated frangible strips are provided on the skirt of the closure. The tear tab is disposed within an indentation on the outer surface of the closure. Pulling off the tear tab along the frangible strips accomplishes removal of the interlocked engaging means, freeing the closure for counterclockwise rotation and removal. At the same time a gaping hole is imparted to the skirt of the cap providing visual evidence of tampering.

Abstract: A child-resistant container including in combination a container and a threadedly engaged closure means. The interior of the closure means is provided with compressible sealing means for fluid-tight sealing of the container. The neck of the container is provided with outwardly radial projections and the skirt of the closure is provided with inwardly radial grooves to engage said projections and provide a child resistance means. The closure means has an indicating marker and the marker is visually aligned with a visible feature of the container when the container is both sealed and in the child-resistant mode.