Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: The presently disclosed subject matter provides a formulation for the use of 1-deoxygalactonojirimycin and/or enzyme replacement therapy for the treatment of Fabry disease.

Abstract: Systems and methods are provided for ink estimation. One embodiment is a system for dynamic ink use estimation. The system includes a cloud computing system. The cloud computing system includes a cloud event service able to receive a print job and potential configurations of a printer selected for printing the print job, and to initialize virtual printers for the printer that each correspond with one of the potential configurations. The cloud computing system also includes the virtual printers, which are able to operate in parallel to estimate amounts of ink used for each configuration during printing of the print job, and to store the estimated amounts of ink in a cloud storage.

Abstract: Systems and methods are provided for ink estimation. One embodiment is a system for dynamically revising ink estimation models. The system includes a memory storing a virtual machine for instantiating virtual printers that estimate amounts of ink used by a printer for print jobs, and a controller able, for each print job, to: identify estimated amounts of ink determined by the virtual printers according to each of multiple configurations for the printer, and identify a chosen configuration and a corresponding actual amount of ink used by the printer. The controller selects a configuration, determines that estimated amounts of ink for the selected configuration have less than a threshold difference from actual amounts of ink for each of multiple print jobs, and updates an ink estimation model at the virtual machine based on the estimated amounts of ink and corresponding print job data for the selected configuration.

Abstract: Systems and methods are provided for ink estimation. One embodiment is a system for dynamic ink use estimation. The system includes a cloud computing system. The cloud computing system includes a cloud event service able to receive a print job and potential configurations of a printer selected for printing the print job, and to initialize virtual printers for the printer that each correspond with one of the potential configurations. The cloud computing system also includes the virtual printers, which are able to operate in parallel to estimate amounts of ink used for each configuration during printing of the print job, and to store the estimated amounts of ink in a cloud storage.

Abstract: Systems and methods are provided for ink estimation. One embodiment is a system for dynamically revising ink estimation models. The system includes a memory storing a virtual machine for instantiating virtual printers that estimate amounts of ink used by a printer for print jobs, and a controller able, for each print job, to: identify estimated amounts of ink determined by the virtual printers according to each of multiple configurations for the printer, and identify a chosen configuration and a corresponding actual amount of ink used by the printer. The controller selects a configuration, determines that estimated amounts of ink for the selected configuration have less than a threshold difference from actual amounts of ink for each of multiple print jobs, and updates an ink estimation model at the virtual machine based on the estimated amounts of ink and corresponding print job data for the selected configuration.

Abstract: System and methods for page alignment for tractorless paper. In one embodiment, an apparatus receives a print job to be printed on a continuous web of print media in a duplex format with multiple first pages across a front of the web and multiple second pages across a back of the web which correspond with the multiple first pages. The apparatus maps pages to sheetlet regions, and applies first offsets to the sheetlet regions on the front of the virtual continuous forms based on operator input. The controller also determines second offsets for the sheetlet regions on the back of the virtual continuous forms based on an additive inverse of the first offsets, and modifies processing of the print job by applying the second offsets to the sheetlet region on the back of the virtual continuous forms to maintain alignment of front pages and back pages across the web.

Abstract: System and methods for page alignment for tractorless paper. In one embodiment, an apparatus receives a print job to be printed on a continuous web of print media in a duplex format with multiple first pages across a front of the web and multiple second pages across a back of the web which correspond with the multiple first pages. The apparatus maps pages to sheetlet regions, and applies first offsets to the sheetlet regions on the front of the virtual continuous forms based on operator input. The controller also determines second offsets for the sheetlet regions on the back of the virtual continuous forms based on an additive inverse of the first offsets, and modifies processing of the print job by applying the second offsets to the sheetlet region on the back of the virtual continuous forms to maintain alignment of front pages and back pages across the web.

Abstract: The invention provides an inflatable insertion device capable of being percutaneously introduced into a patient's body. The insertion device comprises an inflatable element having a distal end and a proximal end and which is operable between a collapsed condition and an inflated condition by introducing an inflating fluid therein. An elongate member extends internally of the inflatable element from its distal end. The internal member is capable of being withdrawn towards the proximal end of the inflatable element to result in the distal end of the element being withdrawn towards the proximal end internally of the element. The invention further provides a locating device comprising a catheter having a catheter tube fitted with one or more inflatable insertion devices at a distal end thereof.

Abstract: The invention provides a non-occlusive dilation and deployment catheter device which includes a catheter having a distal end configured for entering a patient and a proximal end for manipulating the device. A distender is provided at or near the distal end which is movable between a collapsed configuration which enables introduction and removal thereof to and from an operative site in a vessel or other hollow organ of a patient, and an expanded configuration in which the distender assumes a radially expanded condition and defines a flow path therethrough. The distender includes a substantially tubular, radially expandable frame having a plurality of spaced apertures and at least one inflatable tube threaded through the apertures and shaped to extend in a spiral when inflated. The distender is movable to the expanded configuration by inflating the tube, and movable to the collapsed configuration from the expanded configuration by deflating the tube.

Abstract: An expandable stent comprises a cylindrical wall made up of lattice members connected to each other, at least one first arm and at least one second arm. The first arm comprises: a first non-linear member that is connected at each of its axial ends to a lattice member at respective first junctions; a second non-linear member connected at each axial end to a lattice member; and at least one bridge member extending between the first member and the second member. The second arm comprises: a first non-linear member that is connected at each of its axial ends to a lattice member; a second non-linear member connected at each axial end to a lattice member; and at least one bridge member extending between the first member and the second member. The second member of the first arm is generally U-shaped, extending from its axial ends towards: (i) a first axial end of the stent; and (ii) towards the bridge of the first arm.

Abstract: This invention relates to an airway dilation device comprising a catheter; an inflation tube within the catheter, and having a lumen defined by its inner wall; a duct within the catheter, for the insufflation of a fluid, the duct being sealed against any fluid flow between it and the tube; a cluster of balloons, arranged about the catheter, the balloons being manipulated between a stowed condition, in which the balloons are deflated, and a deployed condition, in which the balloons are inflated; and inflating means, for inflating the balloons; characterised in that, when stowed, each balloon is folded and staggered relative to each adjacent balloon, and such that continuous insufflation remains possible, even when deployed. This invention relates, further, to corresponding methods of deployment of devices.

Abstract: A prosthetic heart valve (10) which includes a stent (14) having three leaflets (12) attached thereto is provided. The stent (14) is compressible so as to be capable of being introduced into a patient's body through a minimally invasive procedure and has a ring-like body (16) defining in its height three arch-shaped elements (18). Each element (18) includes an arc (20) and a pair of haunches (22) extending from opposite sides thereof, with three commissural posts (26) formed by the haunches (22) of adjacent elements (18). The leaflets (12) each have an attachment edge (28) and a free edge (30) with a belly (32) extending therebetween. The leaflets (12) are movable between a coapted condition, in which the free edges (30) abut and prevent fluid flow through the valve (10), and an open condition, in which fluid flow through the valve (10) is permitted. The leaflets (12) are made from a polymeric material and are moulded directly onto the stent (14) so as to provide for continuous attachment thereof.

Abstract: A system and method of multi-carrier communication utilizes a farm of superimposed code and random phase values for generation of carrier signals and is resistant to malicious and non-malicious interference in a wireless network, such as an ad-hoc mobile communication network. The system and method includes an encoding/decoding algorithm and the use of a unique and easily generated pseudo random multi-frequency waveform, has high dynamic range, and is flexibly adaptable for different radio networks. The system and method further includes broadcasting a message with a non-secret checksum that is encoded with a hash function.

Abstract: Disclosed is a benefit agent delivery particle comprising a benefit agent; and a chitosan salt at the outer surface of the particle, wherein the chitosan salt comprises a chitosan component and amino acid anion, wherein the amino acid comprises phenylalamine; the amino acid does not comprises tyrosine; and the amino acid does not comprises histidine or the amino acid comprises no greater than 20% of histidine by mole of the total amino acid, wherein the benefit agent comprises fragrance, pro-fragrance, hair conditioning agent, anti-dandruff agent, moisturizers, emollients, dyes, pigments, color care additives, or a mixture thereof.

Abstract: A method for a seller of educational materials including webisodes, dealing with loss prevention, sales and customer service, to sell such materials via security integrators, payroll and human resource outsourcers which are not primarily involved in the business of sales of such training materials to end-user businesses that are the clients of the integrators and outsourcers. Accordingly a form of tangential distribution is practiced capitalizing on a vast threshold between demand and supply and availability and economic feasibility of producing such high quality materials. The method involves identification of tier resellers, selling of a subscription basis training series mainly accessible via password protected online access to, generally, SCORM and Experience API conformant, formatted high quality video materials.

Abstract: Pliable draping apparatus or systems for use with a safety helmet for protecting a user's face, neck and/or ears. The pliable draping material includes a helmet engaging portion and a protection portion coupled to the helmet engaging portion. The protection portion protects at least one of a user's mouth, neck, and ears. The protection apparatus also includes a helmet engaging portion with features allowing easy removing coupling to preexisting clips on various types of safety helmets. In one illustrative embodiment, the helmet engaging portion may be formed as a band of elastic material having reinforced slits for connection to attachment clips on different safety helmets. In some embodiments, the pliable draping system may include a removable and adjustable face mask portion for protection of a user's face. The system may include a sleeve allowing the face mask portion to be stored when not in use.

Abstract: An expandable stent comprises a cylindrical wall made up of lattice members connected to each other, at least one first arm and at least one second arm. The first arm comprises: a first non-linear member that is connected at each of its axial ends to a lattice member at respective first junctions; a second non-linear member connected at each axial end to a lattice member; and at least one bridge member extending between the first member and the second member. The second arm comprises: a first non-linear member that is connected at each of its axial ends to a lattice member; a second non-linear member connected at each axial end to a lattice member; and at least one bridge member extending between the first member and the second member. The second member of the first arm is generally U-shaped, extending from its axial ends towards: (i) a first axial end of the stent; and (ii) towards the bridge of the first arm.

Abstract: A system and method of multi-carrier communication utilizes a farm of superimposed code and random phase values for generation of carrier signals and is resistant to malicious and non-malicious interference in a wireless network, such as an ad-hoc mobile communication network. The system and method includes an encoding/decoding algorithm and the use of a unique and easily generated pseudo random multi-frequency waveform, has high dynamic range, and is flexibly adaptable for different radio networks. The system and method further includes broadcasting a message with a non-secret checksum that is encoded with a hash function.

Abstract: The invention provides an inflatable insertion device capable of being percutaneously introduced into a patient's body. The insertion device comprises an inflatable element having a distal end and a proximal end and which is operable between a collapsed condition and an inflated condition by introducing an inflating fluid therein. An elongate member extends internally of the inflatable element from its distal end. The internal member is capable of being withdrawn towards the proximal end of the inflatable element to result in the distal end of the element being withdrawn towards the proximal end internally of the element. The invention further provides a locating device comprising a catheter having a catheter tube fitted with one or more inflatable insertion devices at a distal end thereof.