Patents by Inventor Kenneth T. Wheeler

Kenneth T. Wheeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor
    Patent number: 7049425
    Abstract: A new variant of the sigma-1 (?1)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—1? (?1?) finds particular use in the non-invasive diagnosis of cancer and more particularly in the diagnosis of proliferative cancer cells.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: May 23, 2006
    Assignee: Wake Forest University
    Inventors: Kenneth T. Wheeler, Robert H. Mach, Steven Childers, Gregory Shelness, Li-Ming Wang
  • Sigma-2 receptors as biomarkers of tumor cell proliferation
    Patent number: 6676925
    Abstract: Detectably-labeled compounds of formula (I) wherein A,B,C,D,E,F,R,X,Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of 2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: January 13, 2004
    Assignee: Wake Forest University
    Inventors: Robert H. Mach, Kenneth T. Wheeler, Biao Yang, Steven R. Childers
  • Sigma-2 receptors as biomarkers of tumor cell proliferation
    Patent number: 6669925
    Abstract: The present invention provides novel sigma-2 ligands (labeled and unlabeled) and the use of the compounds in medical therapy or diagnosis.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: December 30, 2003
    Assignee: Wake Forest University
    Inventors: Robert H. Mach, Kenneth T. Wheeler
  • Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor
    Publication number: 20020061847
    Abstract: A new variant of the sigma-1 (&sgr;1)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—1&bgr; (&sgr;1&bgr;) finds particular use in the non-invasive diagnosis of cancer and more particularly in the diagnosis of proliferative cancer cells.
    Type: Application
    Filed: March 30, 2001
    Publication date: May 23, 2002
    Inventors: Kenneth T. Wheeler, Robert H. Mach, Steven Childers, Gregory Shelness, Li-Ming Wang
  • .sigma.-2 receptors as biomarkers of tumor cell proliferation
    Patent number: 6113877
    Abstract: The invention provides detectably-labeled compounds of formula (I): ##STR1## wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of .sigma.2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: September 5, 2000
    Assignee: Wake Forest University
    Inventors: Robert H. Mach, Kenneth T. Wheeler, Biao Yang, Steven R. Childers