Patents by Inventor Kenneth W. Locke

Kenneth W. Locke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 11944607
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: April 2, 2024
    Assignee: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20220168283
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: July 2, 2021
    Publication date: June 2, 2022
    Applicant: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • IN-LINE GAS ADAPTOR FOR ENDOSCOPIC APPARATUS
    Publication number: 20210290043
    Abstract: The present invention provides an adaptor that is suitable for attachment to an endoscopic device for delivery of a secondary gas. The adaptor generally comprises an adaptor body with first and second fluid transport components and can include a gas inlet on one of the fluid transport components suitable for attachment to a secondary gas source. A scaling member can be included to prevent leakage of any fluid (e.g., liquid or gas) that is transported through channels extending through the fluid transport components. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source in an endoscopy procedure.
    Type: Application
    Filed: April 5, 2021
    Publication date: September 23, 2021
    Applicant: UNITED STATES ENDOSCOPY GROUP, INC.
    Inventors: Jeffrey B. Cushner, Kenneth W. Locke, Christopher R. Stebbins, Kenneth E. Wolcott
  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 11083713
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 10, 2021
    Assignee: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • In-line gas adaptor for endoscopic apparatus
    Patent number: 10966593
    Abstract: The present invention provides an adaptor that is suitable for attachment to an endoscopic device for delivery of a secondary gas. The adaptor generally comprises an adaptor body with first and second fluid transport components and can include a gas inlet on one of the fluid transport components suitable for attachment to a secondary gas source. A sealing member can be included to prevent leakage of any fluid (e.g., liquid or gas) that is transported through channels extending through the fluid transport components. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source in an endoscopy procedure.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: April 6, 2021
    Assignee: UNITED STATES ENDOSCOPY GROUP, INC.
    Inventors: Jeffrey B. Cushner, Kenneth W. Locke, Christopher R. Stebbins, Kenneth E. Wolcott
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20200093805
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: May 1, 2019
    Publication date: March 26, 2020
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20170020851
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: October 7, 2016
    Publication date: January 26, 2017
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20170014390
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: March 23, 2016
    Publication date: January 19, 2017
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS
  • Treatment of amyotrophic lateral sclerosis (ALS) with ibudilast
    Patent number: 9314452
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 19, 2016
    Assignee: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 9114136
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 25, 2015
    Assignee: MEDICINOVA, INC.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20150011581
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20140171463
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Applicant: MediciNova, Inc.
    Inventors: Michael E. KALAFER, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • IN-LINE GAS ADAPTOR FOR ENDOSCOPIC APPARATUS
    Publication number: 20130237761
    Abstract: The present invention provides an adaptor that is suitable for attachment to an endoscopic device for delivery of a secondary gas. The adaptor generally comprises an adaptor body with first and second fluid transport components and can include a gas inlet on one of the fluid transport components suitable for attachment to a secondary gas source. A sealing member can be included to prevent leakage of any fluid (e.g., liquid or gas) that is transported through channels extending through the fluid transport components. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source in an endoscopy procedure.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 12, 2013
    Applicant: Bracco Diagnostics Inc.
    Inventors: Jeffrey B. Cushner, Kenneth W. Locke, Christopher R. Stebbins, Kenneth E. Wolcott
  • In-line gas adaptor for endoscopic apparatus
    Patent number: 8454498
    Abstract: The present invention provides an adaptor that is suitable for attachment to an endoscopic device for delivery of a secondary gas. The adaptor generally comprises an adaptor body with first and second fluid transport components and can include a gas inlet on one of the fluid transport components suitable for attachment to a secondary gas source. A sealing member can be included to prevent leakage of any fluid (e.g., liquid or gas) that is transported through channels extending through the fluid transport components. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source in an endoscopy procedure.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: June 4, 2013
    Assignee: Bracco Diagnostics Inc.
    Inventors: Jeffrey B. Cushner, Kenneth W. Locke, Christopher R. Stebbins, Kenneth E. Wolcott
  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 8338453
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2 -isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: December 25, 2012
    Assignee: Medicinova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20120214839
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: February 22, 2012
    Publication date: August 23, 2012
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • Treatment of progressive neurodegenerative disease with ibudilast
    Patent number: 8138201
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: March 20, 2012
    Assignee: MediciNova, Inc.
    Inventors: Michael E. Kalafer, Kenneth W. Locke, Kazuko Matsuda, Richard E. Gammans
  • IN-LINE GAS ADAPTOR FOR ENDOSCOPIC APPARATUS
    Publication number: 20110054256
    Abstract: The present invention provides an adaptor that is suitable for attachment to an endoscopic device for delivery of a secondary gas. The adaptor generally comprises an adaptor body with first and second fluid transport components and can include a gas inlet on one of the fluid transport components suitable for attachment to a secondary gas source. A sealing member can be included to prevent leakage of any fluid (e.g., liquid or gas) that is transported through channels extending through the fluid transport components. The adaptor may be used in endoscopy methods and is particularly useful for adding a secondary gas source in an endoscopy procedure.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 3, 2011
    Inventors: Jeffrey B. Cushner, Kenneth W. Locke, Christopher R. Stebbins, Kenneth E. Wolcott
  • IBUDILAST AND IMMUNOMODULATORS COMBINATION
    Publication number: 20100260755
    Abstract: The invention contemplates methods and compositions for treating multiple sclerosis including the administration of a PDE inhibitor and at least one immunomodulator comprising mitoxantrone, natalizumab, fingolimod, laquinimod, cladribine, dimethylfumarate or a mixture comprising synthetic polypeptide analogs of myelin basic protein, including alanine, glutamic acid, lysine, and tyrosine amino acid residues, in a therapeutically effective amount. A preferred PDE inhibitor includes ibudilast.
    Type: Application
    Filed: April 7, 2010
    Publication date: October 14, 2010
    Inventors: Richard E. GAMMANS, Kenneth W. Locke, Michael E. Kalafer
  • TREATMENT OF PROGRESSIVE NEURODEGENERATIVE DISEASE WITH IBUDILAST
    Publication number: 20090062330
    Abstract: Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).
    Type: Application
    Filed: July 8, 2008
    Publication date: March 5, 2009
    Inventors: Michael E. KALAFER, Kenneth W. LOCKE, Kazuko MATSUDA, Richard E. GAMMANS