Abstract: Disclosed are compositions and methods to generate a protective or therapeutic immune response to neoplastic cells (e.g., tumor cells) which, in nature, lack a CoCAM surface molecule essential for a cytotoxic immune response. GPI-anchored CoCAM molecules are incorporated (by GPI-protein transfer) into neoplastic cells, neoplastic cell membrane preparations or neoplastic membrane vesicle preparations and formulated in immunogenic compositions. A specifically exemplified GPI-CoCAM is a B7.1/CD16B fusion protein, having the GPI anchor domain from the CD16B molecule.

Abstract: Disclosed are compositions and methods to generate a protective or therapeutic immune response to neoplastic cells (e.g., tumor cells) which, in nature, lack a CoCAM surface molecule essential for a cytotoxic immune response. GPI-anchored CoCAM molecules are incorporated (by GPI-protein transfer) into neoplastic cells, neoplastic cell membrane preparations or neoplastic membrane vesicle preparations and formulated in immunogenic compositions. A specifically exemplified GPI-CoCAM is a B7.1/CD16B fusion protein, having the GPI anchor domain from the CD16B molecule.

Abstract: The present invention provides a noninvasive method for diagnosing and/or predicting a rejection episode in a transplant patient, for example, in a heart transplant patient, by determining a rise in the frequency of thioguanine-resistant mutant peripheral blood mononuclear cells. Those resistant mutant cells have a deficiency in the purine salvage enzyme hypoxanthine guanine phosphoribosyltransferase. The relative frequency of the mutant cells in the population from a sample can be determined by direct plating in the presence of a selection medium and by determining of the mutation by polymerase chain reaction technology.

Abstract: A preparation and a method are described for emergency, interim treatment extensive burn injuries, e.g., flash burns, to external portions of a person. A solution of the polymer poly-.epsilon.-caprolactone is a volatile solvent, such as acetone or tetrahydrofuran, is applied to the burn area by spraying or swabbing, so that upon evaporation of the solvent a film of the polymer is left to serve as a barrier to insensible water loss.