Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract: Disclosed inter alia is the use of certain chromenone derivatives, which are modulators of a mitotic kinesin such as KSP, in the treatment of cellular proliferative diseases. The chromenones derivatives are administered with another chemotherapeutic agent selected from neutropenia treatment agents, alkylating agents, antimetabolites, platinating agents, topoisomerase inhibitors, tubulin agents and signalling inhibitors (e.g., kinase inhibitors). Pharmaceutical compositions comprising one or both types of active agents are also disclosed.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.

Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.

Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.

Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.

Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif15, antibodies to HsKif15, methods of screening for HsKif15 modulators using biologically active HsKif15, and kits for screening for HsKif15 modulators.

Abstract: A digital data processor is provided to multiply data elements by coefficients. It includes a systolic array of cells consisting of nearest neighbor connected gated full adders. The cells multiply data bits received from laterally adjacent cells and subsequently pass them on. The product is added to a cumulative sum bit from a cell above and to a carry bit recirculated from an earlier computation. The output is passed to a cell below, and a new carry bit is recirculated for addition in a subsequent computation. Data and coefficients are input in counterflow to opposite sides of the array. An adder tree accumulates non-simultaneously computed contributions to individual output terms. The tree incorporates a delay and switches arranged to implement or bypass the delay according to earlier or later computation of a contribution. By virtue of this accumulation, the processor provides reduced cell redundancy compared to the prior art.

Abstract: A digital data processor for matrix/matrix multiplication includes a systolic array of nearest neighbor connected gated full adders. The adders are arranged to multiply two input data bits and to add their product to an input cumulative sum bit and a carry bit from a lower order bit computation. The result and input data bits are output to respective neighboring cells, a new carry bit being recirculated for later addition to a higher order bit computation. Column elements of one matrix and row elements of the other are input to either side of the array bit-serially, least significant bit leading, for mutual counterpropagation therethrough with a cumulative time delay between input of adjacent columns or rows. Bit-level matrix interactions for product matrix computation occur at individual cells. Pairs of intercalated adder trees are connected switchably to the array to accumulate bit-level contributions to product matrix elements.

Abstract: A novel hanger framework assembly comprises an inserted assembly to be placed within the interior confines of industry-known tote boxes as commonly used for the handling, carrying, storing and shipping of electrostatic charge sensitive electronic circuits, PC boards and components, which framework assembly includes novel channel configuration utilized to capture and guide movements of hanger bar members, to receive insertable corner brace members and an encircling strap fastener, and within which channels the end portions of suspendable insulating materials are captured, which insulating materials also comprise flexible folders to be suspended from the hanger bar members and within which objects to be protected from electrostatic discharge can be placed.