Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: Provided herein are methods of treating a subject by administering a combination of an activatable cytokine construct (ACC) and a PD-1/PD-L1 pathway inhibitor in which the ACC includes: a first monomer construct including an optional first peptide mask (PM1), an optional third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1; and a second monomer construct including an optional second peptide mask (PM2), an optional forth cleavable moiety (CM4), a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), wherein the CM2 is positioned between the CP2 and the DD2; wherein the DD1 and the DD2 bind to each other thereby forming a dimer of the first monomer construct and the second monomer construct; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control l

Abstract: A surface shape determination system includes a surface shape sensor in the form of a flexible and stretchable elastomeric substrate with strain/displacement sensing elements embedded in it. The sensor may be a single-core optical fiber with a series of fiber Bragg Gratings (FBGs) located at predetermined positions along its length. A light source provides an incident light spectrum at one end of the fiber. Each grating of the fiber has index modulation which causes particular wavelengths of the light spectrum that do not satisfy the Bragg condition to be reflected back in the fiber. The refractive index of each grating changes with strain on the substrate due to deflection of it. An interrogator captures the reflected wavelengths and retrieves signal information therefrom. A processor receives the output of the interrogator and performs non-linear regression analysis on the information using a neural network to reconstruct the surface morphology in real-time.

Abstract: A chain lock includes a lock body having a first closure part, a second closure part, and a combination locking mechanism that is aligned along a lock axis. The chain lock having a bolt selectively locked to the lock body by the combination locking mechanism. The lock body has a chain connection part permanently connected to the bolt via a chain. The combination locking mechanism having a plurality of rotatable code setting rings arranged between the first and second closure parts. At a first end the lock body has at least one first fastening pin that engages through the housing sleeve into an annular groove of the chain connection part. At a second end the lock body has at least one second fastening pin that engages through the housing sleeve into the second closure part of the lock body and that fixes the second closure part to the housing sleeve.

Abstract: An optical signal analyzing apparatus enables real-time and single-shot analysis simultaneously in both time and frequency domains with spectro-temporal analysis. The apparatus includes a fiber tap coupler for receiving an input optical signal from continuous wave (CW) to ultra-short pulses (femtosecond-picosecond). An optical splitter directs part of the signal to a frequency channel and part to a time channel A photodiode in the time channel directly monitors the intensity evolution and converts it to an electrical signal. In the frequency channel, two sub-channels are provided: one for CW/quasi-CW and one for short-pulse components. A signal processor analyses the time- and frequency-domain data from the time channel and frequency channel and displays the temporal and spectral evolutions simultaneously, so that the two different pieces of information of a non-repeated dynamic event can be correlated in different domains.

Abstract: A vaporizer device may include various modular components. The vaporizer device may include a first subassembly. The first subassembly may include a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device may include a second subassembly. The second subassembly may include a skeleton defining a rigid tray that retains at least a power source. The vaporizer device may also include a third subassembly. The third subassembly may include a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: Briefly, methods and/or systems, are described for a wavelength-dispersive mode-locked fiber-ring laser, which generates an Airy beam profile for stable optical pulses.

Abstract: An optical signal analyzing apparatus enables real-time and single-shot analysis simultaneously in both time and frequency domains with spectro-temporal analysis. The apparatus includes a fiber tap coupler for receiving an input optical signal from continuous wave (CW) to ultra-short pulses (femtosecond-picosecond). An optical splitter directs part of the signal to a frequency channel and part to a time channel A photodiode in the time channel directly monitors the intensity evolution and converts it to an electrical signal. In the frequency channel, two sub-channels are provided: one for CW/quasi-CW and one for short-pulse components. A signal processor analyses the time- and frequency-domain data from the time channel and frequency channel and displays the temporal and spectral evolutions simultaneously, so that the two different pieces of information of a non-repeated dynamic event can be correlated in different domains.

Abstract: A vaporizer device may include various modular components. The vaporizer device may include a first subassembly. The first subassembly may include a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device may include a second subassembly. The second subassembly may include a skeleton defining a rigid tray that retains at least a power source. The vaporizer device may also include a third subassembly. The third subassembly may include a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: A surface shape determination system includes a surface shape sensor in the form of a flexible and stretchable elastomeric substrate with strain/displacement sensing elements embedded in it. The sensor may be a single-core optical fiber with a series of fiber Bragg Gratings (FBGs) located at predetermined positions along its length. A light source provides an incident light spectrum at one end of the fiber. Each grating of the fiber has index modulation which causes particular wavelengths of the light spectrum that do not satisfy the Bragg condition to be reflected back in the fiber. The refractive index of each grating changes with strain on the substrate due to deflection of it. An interrogator captures the reflected wavelengths and retrieves signal information therefrom. A processor receives the output of the interrogator and performs non-linear regression analysis on the information using a neural network to reconstruct the surface morphology in real-time.

Abstract: Systems and methods for wireless energy transfer are described. A transmitter unit has a transmitter resonator with a coil that is coupled to a power supply to wirelessly transmit power to a receiver unit. A receiver unit has a receiver resonator with a coil coupled to a device load. The receiver unit can include a ferrite enclosure to prevent transmission of magnetic flux into electronics of the receiver unit, and can include ferrite fins to increase a coupling between the transmitter resonator and the receiver resonator.

Abstract: The present invention relates to granules comprising an active substance, obtained by spray-drying an emulsion comprising said active substance, solid particles, water and a water-soluble biopolymer having a molecular weight below 100 KDa. The invention further relates to a process for obtaining such granules and to products containing them.

Abstract: Briefly, methods and/or systems, are described for a wavelength-dispersive mode-locked fiber-ring laser, which generates an Airy beam profile for stable optical pulses.

Abstract: A fluid resistant electrical connector for an implantable medical device includes a first connector assembly and a second connector assembly. The first connector assembly includes a first housing, an elongated coupling member, and first electrical contacts distributed around the coupling member. The second connector assembly includes a second housing, second electrical contacts, and a retention member. The second housing has a coupling member receptacle and a retention member receptacle. The coupling member receptacle is shaped to accommodate a distal portion of the coupling member. The retention member is partially accommodated by the retention member receptacle and movable between an insertion configuration accommodating coupling of the first and second connector assemblies and a retention configuration retaining the coupling member to prevent inadvertent uncoupling of the electrical connector.

Abstract: The present invention relates to granules comprising an active substance, obtained by spray-drying an emulsion comprising said active substance, solid particles, water and a water-soluble biopolymer having a molecular weight below 100 KDa. The invention further relates to a process for obtaining such granules and to products containing them.

Abstract: The present invention relates to granules comprising an active substance, obtained by spray-drying an emulsion comprising said active substance, solid particles, water and a water-soluble biopolymer having a molecular weight below 100 KDa. The invention further relates to a process for obtaining such granules and to products containing them.

Abstract: A fluid resistant electrical connector for an implantable medical device includes a first connector assembly and a second connector assembly. The first connector assembly includes a first housing, an elongated coupling member, and first electrical contacts distributed around the coupling member. The second connector assembly includes a second housing, second electrical contacts, and a retention member. The second housing has a coupling member receptacle and a retention member receptacle. The coupling member receptacle is shaped to accommodate a distal portion of the coupling member. The retention member is partially accommodated by the retention member receptacle and movable between an insertion configuration accommodating coupling of the first and second connector assemblies and a retention configuration retaining the coupling member to prevent inadvertent uncoupling of the electrical connector.

Abstract: A method for pre-wetting a polypropylene (PP) filter for filtering slurry and a PP filter package are provided. The method for pre-wetting the PP filter for filter slurry consists of steps of: pre-wetting a PP filtering media of the PP filter and packaging the pre-wetted PP filter in a packaging member sealingly. A PP filter package includes a cartridge, a PP filtering media and a packaging member. The PP filtering media is disposed in the cartridge to form a PP filter. The PP filtering media is pre-wetted, and the PP filter is sealingly packaged in the packaging member.