Abstract: Provided herein are guanidinoacetic acid or its derivatives thereof, compositions comprising the same, as well as the use thereof, particularly for topical or systematic treatment of pain, itch, eczema or other inflammatory disorders.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: An axle housing assembly and a method of manufacture. A friction weld may join a spindle to an arm portion of the axle housing assembly. An extension weld may encircle the arm portion. The extension weld may extend from the friction weld in a direction that may extend away from the spindle.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: An axle housing assembly and a method of manufacture. A friction weld may join a spindle to an arm portion of the axle housing assembly. An extension weld may encircle the arm portion. The extension weld may extend from the friction weld in a direction that may extend away from the spindle.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: An approach to facilitating consideration-based non-player character counseling is provided. A non-player character counsel may be controlled within a game space to provide counsel content to users in exchange for virtual consideration purchased with real world money. For example, responsive to reception of adequate virtual consideration from a first user, the non-player character counsel may be controlled to provide a first set of counsel content to the first user in the game space. The first set of counsel content may be a subset of the counsel content provided by the non-player character counsel to the users in the game space. The counsel content may include instructions for and/or demonstrations of activities to be performed by a first character under control of the first user in the game space.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: Targeted recommendations may be provided to specific user segments. The users may be segmented on or more user parameters that facilitate targeted provision of recommendations to the individual segments of users. A recommendation may prompt a user to take a recommended action in the game.

Abstract: An approach to facilitating consideration-based non-player character counseling is provided. A non-player character counsel may be controlled within a game space to provide counsel content to users in exchange for virtual consideration purchased with real world money. For example, responsive to reception of adequate virtual consideration from a first user, the non-player character counsel may be controlled to provide a first set of counsel content to the first user in the game space. The first set of counsel content may be a subset of the counsel content provided by the non-player character counsel to the users in the game space. The counsel content may include instructions for and/or demonstrations of activities to be performed by a first character under control of the first user in the game space.

Abstract: Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide are produced from a single polynucleotide. The polynucleotide can comprise a sequence (or sequence encoding a polypeptide) that mediates separation of a membrane anchor from the polypeptide. In some embodiments, a desired ratio of secreted to surface-bound polypeptide is obtained by selecting a sequence that mediates a desired level of separation of the membrane anchor from the polypeptide.