Patents by Inventor Kensei Yoshikawa
Kensei Yoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5521311Abstract: The present compounds represented by the formula: ##STR1## (wherein R.sup.1 is a phenyl group, a halophenyl group or a cycloalkyl group having 3 to 8 carbon atoms, R.sup.2 is a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, R.sup.3 is a hydrogen atom, an alkyl group having 1 to 7 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 3 to 5 carbon atoms or a benzyl group, or R.sup.2 and R.sup.3 are bonded together to form a 5- to 7-membered heterocycle) and salts thereof have potent anti-inflammatory, antipyretic, analgesic and anti-allergic actions with less side effects such as gastrointestinal disorders and with such a high safety as to permit long-term administration.Type: GrantFiled: August 14, 1995Date of Patent: May 28, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Shiuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama
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Patent number: 5449826Abstract: To provide an excellent compound having anti-inflammatory, antipyretic, analgesic and antirheumatic actions.A 5-amino-2-phenoxysulfonanilide compound represented by the formula: ##STR1## and the salts thereof have potent anti-inflammatory, antipyretic, analgesic and antirheumatic actions, and therefore they are useful as anti-inflammatory, antipyretic, analgesic and antirheumatic agents.Type: GrantFiled: December 9, 1994Date of Patent: September 12, 1995Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Shuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama
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Patent number: 5374764Abstract: 5-Aminosulfonanilide compounds represented by the formula: ##STR1## (wherein R is a hydrogen atom, a formyl group, an acetyl group, a propionyl group, an n-butyryl group, an n-valeryl group, an ethoxyoxalyl group, an n-propoxyoxalyl group, a methoxycarbonylacetyl group or a 3-ethoxycarbonylpropionyl group) have potent anti-inflammatory, antipyretic, analgesic and anti-allergic actions, and therefore they are useful as anti-inflammatory, antipyretic, analgesic and anti-allergic agents.Type: GrantFiled: February 3, 1994Date of Patent: December 20, 1994Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Shiuji Saito, Yohichi Shimazaki, Mariko Kashiwa, Katsuo Hatayama
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Patent number: 4937360Abstract: N-substituted amide derivative represented by the formula ##STR1## wherein A is --CH(OH)-- or --C(.dbd.O)--, R.sup.1 is a hydrogen atom or an lkyl group having 1 to 3 carbon atoms, and R.sup.2 is an alkyl group having 1 to 6 carbon atoms, are disclosed. These compounds are useful for prevention and therapy for liver diseases.Type: GrantFiled: June 28, 1989Date of Patent: June 26, 1990Assignees: Taisho Pharmaceutical Co., Ltd., The Institute of Materia Medica of Chinese Academy of Medical SciencesInventors: Geng-tao Liu, Liang Huang, Er-chang Rao, Jin Zhou, Yan Li, Katsuo Hatayama, Tatsuhiko Sano, Kensei Yoshikawa, Shohei Higuchi, Iwao Arai
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Patent number: 4885367Abstract: Sulfonanilide compounds represented by the formula ##STR1## wherein R.sup.1 is a lower alkyl group or a trifluoromethyl group, R.sup.2 is a cycloalkylidenemethyl group, a group of the formula --A--R.sup.3 (wherein A is an oxygen atom, a sulfur atom, a sulfynyl group or a sulfinyl group and R.sup.3 is a cycloalkyl group having 5-8 carbon atoms; a cycloalkyl group having 5-8 carbon atoms substituted by one or two of a lower alkyl group, an oxo group, a hydroxyl group or a methanesulfonyloxy group, a tetrahydropyranyl group; a tetrahydrothiopyranyl group; or a 1-methyl-piperidyl group) or a group of the formula --B--R.sup.4 (wherein B is a carbonyl group, a hydroxymethylene group or a methylene group, R.sup.4 is a cycloalkyl group having 5-8 carbon atoms) and the pharmaceutically acceptable salts thereof have anti-inflammatory activity.Type: GrantFiled: November 16, 1988Date of Patent: December 5, 1989Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Kensei Yoshikawa, Yutaka Ohuchi, Kazuto Sekiuchi, Shiuji Saito, Katsuo Hatayama, Kaoru Sota
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Patent number: 4557871Abstract: Novel styrene derivatives of the general formula ##STR1## wherein X is hydrogen or halogen, X.sup.1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, --COOR.sup.1 or --COR.sup.2 wherein R.sup.1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or said alkyl substituted with hydroxy, methoxy, pyridyl or alkanoyloxy having 2 to 16 carbon atoms, and R.sup.2 is amino, hydroxyamino mono-(or di-)alkylamino in which the alkyl moiety contains 1 or 2 carbon atoms, ethoxycarbonylmethylamino, carboxymethylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino, N-methylpiperazino, phenylamino, phenylamino substituted with one or two of halogen, hydroxy, methyl, methoxy, trifluoromethyl or carboxyl at the phenyl ring, and the pharmaceutically acceptable salts thereof when Y is carboxyl are disclosed. These compounds exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.Type: GrantFiled: May 14, 1984Date of Patent: December 10, 1985Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Katsuo Hatayama, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Tomomi Ota, Kazuto Sekiuchi, Kaoru Sota
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Patent number: 4436939Abstract: A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100.degree. C. and 150.degree. C. to form a Grignard reagent, and then reacting it with acetaldehyde.Type: GrantFiled: August 25, 1982Date of Patent: March 13, 1984Assignees: Taisho Pharmaceutical Co., Ltd., Kuraray Co., Ltd.Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
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Patent number: 4433160Abstract: A process for producing an .alpha.-arylalkanoic acid ester represented by the general formula ##STR1## wherein Ar represents an aryl group which may optionally be substituted, and R.sup.1 and R.sup.2, independently from each other, represent a lower alkyl group,which comprises reacting a Grignard reagent prepared from an aryl halide of the general formulaAr--X.sup.1 (II)wherein Ar is as defined above and X.sup.1 represents a halogen atom,and magnesium, with an .alpha.-haloalkanoic acid ester of the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and X.sup.2 represents a halogen atom,said reaction of the Grignard reagent with the .alpha.-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.Type: GrantFiled: August 25, 1982Date of Patent: February 21, 1984Assignee: Taisho Pharmaceutical Company, Ltd.Inventors: Takehiro Amano, Kensei Yoshikawa, Tatsuhiko Sano, Yutaka Ohuchi, Michihiro Ishiguro, Manzo Shiono, Yoshiji Fujita, Takashi Nishida
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Patent number: 4420631Abstract: A novel carboxylic acid ester having the following general formula ##STR1## wherein R is alkoxyalkyl having 2 to 6 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, tetrahydrofurfuryl, or alkyl having 1 to 6 carbon atoms optionally substituted with 1 or 2 hydroxyl groups, is a useful anti-inflammatory and analgesic agent.Type: GrantFiled: May 19, 1982Date of Patent: December 13, 1983Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Takehiro Amano, Toshihisa Ogawa, Kensei Yoshikawa, Yoshinori Shiobara, Tatsuhiko Sano, Yutaka Ohuchi, Tohru Tanami, Shoichi Ito, Jiro Sawada
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Patent number: 4189607Abstract: Anilinotropone derivatives represented by the following formula: ##STR1## wherein R is hydrogen or methyl and pharmaceutically acceptable salts thereof are disclosed. They exhibit anti-inflammatory and analgesic activity with low gastrointestinal action.Type: GrantFiled: March 26, 1979Date of Patent: February 19, 1980Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Takehiro Amano, Kensei Yoshikawa, Jiro Sawada, Michitada Sasajima