Abstract: An object of the present invention is to provide a combination pharmaceutical which is capable of preventing or suppressing the development of resistance to the pyrimidine antimetabolite, a prophylactic or suppressive agent for the development of resistance to a pyrimidine antimetabolite, and a method of treating a disease using the above combination pharmaceutical. The present invention provides a combination pharmaceutical comprising a pyrimidine antimetabolite and 5-hydroxy-1H-imidazole-4-carboxamide, wherein the dose per one time of Compound A is 50 to 500 mg/m2 and a daily dose thereof is 100 to 1,000 mg/m2.

Abstract: An object of the present invention is to provide a method and apparatus for predicting an effective dose of or the sensitivity to 5-hydroxy-1H-imidazole-4-carboxamide, which are capable of performing a determination in a simple operation and a short time, a method for determining amounts of xanthosine monophosphate, and a treatment agent and treatment method for treating myelodysplastic syndrome. According to the present invention, provided are a method for predicting an effective dose of or the sensitivity to 5-hydroxy-1H-imidazole-4-carboxamide, including determining amounts of xanthosine monophosphate in blood and a prediction apparatus, a method for determining amounts of xanthosine monophosphate, including determining xanthosine monophosphate in blood in two different determining conditions by mass spectrometry, and a treatment agent and treatment method for treating myelodysplastic syndrome.

Abstract: A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.

Abstract: A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.

Abstract: A process for forming a polyolefin coating layer onto a surface of a metal which comprises coating an uncured epoxy resin layer onto the surface of a metal and melt-bonding a polyolefin modified with an unsaturated carboxylic acid or an anhydride thereof onto the uncured epoxy resin layer coated onto said metal surface. The coating layer has a high bonding strength and excellent water resistance, especially resistance against brine.

Abstract: A process for forming a polyolefin coating layer onto a surface of a metal which comprises coating an uncured epoxy resin layer onto the surface of a metal and melt-bonding a polyolefin modified with an unsaturated carboxylic acid or an anhydride thereof onto the uncured epoxy resin layer coated onto said metal surface. The coating layer has a high bonding strength and excellent water resistance, especially resistance against brine.