Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope insertion observation apparatus includes a processor designed to perform functions including: detecting an insertion state of an insertion portion of an endoscope that is insertable into and extractable from a subject; determining whether or not the insertion portion has reached a second site in the subject from a first site in the subject and/or whether the insertion portion has reached the first site from the second site in the subject based on a detection result of the insertion state; and calculating a duration of movement of the insertion portion from the first site to the second site after determining that the insertion portion has reached the second site, or a duration of movement of the insertion portion from the second site to the first site after determining that the insertion portion has reached the first site.

Abstract: The present invention provides a novel antibody targeting TLR9.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope apparatus including a connector included in an endoscope and connected to an endoscope connection portion of a video processor, a fluid feeding apparatus including a tube configured to transmit fluid to the endoscope, a connection detector configured to detect a connection state of the tube with the connector of the endoscope, a control unit configured to detect an ON/OFF state of a power source of the fluid feeding apparatus, determine an abnormality exists when the connection detector detects that the tube is in a disconnected state with the connector of the endoscope and the power source of the fluid feeding apparatus is detected to be in an ON state, and output a notification of the determined abnormality, and a display configured to display the notification of the abnormality outputted by the control unit.

Abstract: An object of the present invention is to provide a technique for detecting human TLR7. Human TLR7 in a sample can be detected through an ELISA method or the like using an anti-human TLR7 antibody. The present invention enables use of human TLR7 as a marker indicating the pathological condition of an autoimmune disease.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope insertion shape observation apparatus has a processor configured to detect an insertion shape of an insertion portion inserted into a subject P, and calculate operation information, including one of easy insertion information or difficult insertion information, of insertion operation obtained in operation of inserting the insertion portion. The operation information is determined based on an insertion length of the insertion portion. The processor is also configured to simultaneously display of a result of the generation and the insertion shape on the monitor, and change between the easy insertion information and the difficult insertion information.

Abstract: An endoscope insertion observation apparatus includes a processor designed to perform functions including: detecting an insertion state of an insertion portion of an endoscope that is insertable into and extractable from a subject; determining whether or not the insertion portion has reached a second site in the subject from a first site in the subject and/or whether the insertion portion has reached the first site from the second site in the subject based on a detection result of the insertion state; and calculating a duration of movement of the insertion portion from the first site to the second site after determining that the insertion portion has reached the second site, or a duration of movement of the insertion portion from the second site to the first site after determining that the insertion portion has reached the first site.

Abstract: The present invention provides a novel antibody targeting TLR9.

Abstract: An endoscope apparatus including a connector included in an endoscope and connected to an endoscope connection portion of a video processor, a fluid feeding apparatus including a tube configured to transmit fluid to the endoscope, a connection detector configured to detect a connection state of the tube with the connector of the endoscope, a control unit configured to detect an ON/OFF state of a power source of the fluid feeding apparatus, determine an abnormality exists when the connection detector detects that the tube is in a disconnected state with the connector of the endoscope and the power source of the fluid feeding apparatus is detected to be in an ON state, and output a notification of the determined abnormality, and a display configured to display the notification of the abnormality outputted by the control unit.

Abstract: An endoscope insertion shape observation apparatus includes an insertion section configured to be inserted into a subject, and a processor that detects an insertion shape of the insertion section, generates an insertion shape image representing the insertion shape, generates a body outer shape image representing a body outer shape of the subject, and performs display control to simultaneously display the insertion shape image and the body outer shape image in a positional relationship corresponding to a positional relationship, in a body cavity of the subject, of the insertion section on a display screen. The display control also switches between display or non-display of the body outer shape image or a type of the body outer shape image depending on an insertion position, in the body cavity of the subject, of the insertion section.

Abstract: An object of the present invention is to provide a highly-safe and highly-specific preventive or therapeutic agent for inflammatory diseases targeting a TLR7 or TLR9 molecule. The present invention provides a preventive or therapeutic agent for inflammatory diseases containing an anti-TLR7 antibody or anti-TLR9 antibody.

Abstract: An endoscope insertion shape observation apparatus includes an endoscope, a magnetic field generation coil provided at an insertion portion of the endoscope and configured to generate a magnetic field, an antenna unit configured to receive a coil signal from the magnetic field generation coil, a bending portion configured to bend the insertion portion, a bending drive section configured to drive the bending portion to bend, an insertion shape processing circuit configured to generate an insertion shape of the endoscope inserted into a subject according to a signal received from the antenna unit, a touch panel configured to display a generation result of the insertion shape processing circuit and be able to perform touch operation, and a drive section control circuit configured to control a drive amount of the bending drive section based on the touch operation on a desired location of the insertion shape displayed on the touch panel.

Abstract: An endoscope insertion shape observation apparatus includes an endoscope, a magnetic field generation coil provided at an insertion portion of the endoscope and configured to generate a magnetic field, an antenna unit configured to receive a coil signal from the magnetic field generation coil, a bending portion configured to bend the insertion portion, a bending drive section configured to drive the bending portion to bend, an insertion shape processing circuit configured to generate an insertion shape of the endoscope inserted into a subject according to a signal received from the antenna unit, a touch panel configured to display a generation result of the insertion shape processing circuit and be able to perform touch operation, and a drive section control circuit configured to control a drive amount of the bending drive section based on the touch operation on a desired location of the insertion shape displayed on the touch panel.

Abstract: An insertion apparatus includes an insertion portion, a power spiral tube provided with a spiral fin portion configured to extend in a spiral shape, the power spiral tube being provided on an outer circumferential direction side of the insertion portion so as to be rotatable with respect to the insertion portion around a longitudinal axis, a first motor configured to generate a drive force to rotate the power spiral tube, an operation section provided on a proximal end side of the insertion portion, a second motor configured to generate a drive force to rotate the insertion portion pivotably held to the operation section, and a second motor drive circuit configured to calculate torque to be added to the power spiral tube and perform control so as to drive the second motor in accordance with torque added to the first motor.

Abstract: An object of the present invention is to provide a highly-safe and highly-specific preventive or therapeutic agent for inflammatory diseases targeting a TLR7 or TLR9 molecule. The present invention provides a preventive or therapeutic agent for inflammatory diseases containing an anti-TLR7 antibody or anti-TLR9 antibody.

Abstract: A detecting apparatus includes: a change-over switch for switching on/off display of a scope model on a liquid crystal monitor; a position calculating portion for calculating respective positions of source coils; a scope model generating portion for generating a scope model of an electronic endoscope based on the respective positions of the source coils calculated by the position calculating portion; and a selector for selectively outputting to the liquid crystal monitor a display-pause-time image stored in a display-pause-time image storing portion and a scope model image from the scope model generating portion; and a control portion for controlling each of these portions. The detecting apparatus thus displays an insertion shape of the endoscope at a timing as needed.