Abstract: In endoscopy, each of a display controller and a recording controller acquires a first curved shape of an endoscope insertion portion when an endoscope distal end portion is located at a predetermined site, an endoscopic image captured in the endoscopy, and a second shape of an endoscope insertion portion when the endoscopic image is captured. The recording controller may record the first curved shape of the endoscope insertion portion, the endoscopic image, and the second curved shape of the endoscope insertion portion in a storage device. The display controller may simultaneously display the first curved shape of the endoscope insertion portion and the second curved shape of the endoscope insertion portion on a display device.

Abstract: An examination time period evaluator acquires a time evaluation index related to a predetermined examination step (e.g. a net observation step) in an endoscopic examination. An image classifier acquires an implementation record of the endoscopic examination. An examination time period classifier calculates an actual time, i.e. a time required for the predetermined examination step, based on the implementation record. A display controller may display the evaluation index and the actual time on a display apparatus. The display controller may further display a comparison result between the evaluation index and the actual time on the display apparatus.

Abstract: A continuously variable transmission includes a primary shaft, a secondary shaft, a primary pulley, a secondary pulley, a first power transmission member, a primary sprocket, a secondary sprocket, a second power transmission member, and a power transmission switch. The first power transmission member has a loop shape and is wrapped around the primary pulley and the secondary pulley. The primary sprocket is disposed on the primary shaft. The secondary sprocket is disposed on the secondary shaft. The second power transmission member has a loop shape and is wrapped around the primary sprocket and the secondary sprocket. The power transmission switch disables power transmission by the second power transmission member when the first power transmission member is in a normal condition and enables the power transmission by the second power transmission member when the first power transmission member is in an abnormal condition.

Abstract: An endoscopic image acquisition unit acquires shape information of an endoscope insertion part during endoscopic examination. According to a priority condition, executed is at least either: a process by an insertion status estimation unit entering the shape information to an insertion status learning model, thereby acquiring, from the insertion status learning model, an insertion status category resulted from categorization of insertion status of the endoscope insertion part; or, a process by a shape determination unit applying the shape information to a shape category determination logic, thereby acquiring an insertion shape category resulted from categorization of insertion shape of the endoscope insertion part.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope insertion observation apparatus includes a processor designed to perform functions including: detecting an insertion state of an insertion portion of an endoscope that is insertable into and extractable from a subject; determining whether or not the insertion portion has reached a second site in the subject from a first site in the subject and/or whether the insertion portion has reached the first site from the second site in the subject based on a detection result of the insertion state; and calculating a duration of movement of the insertion portion from the first site to the second site after determining that the insertion portion has reached the second site, or a duration of movement of the insertion portion from the second site to the first site after determining that the insertion portion has reached the first site.

Abstract: The present invention provides a novel antibody targeting TLR9.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope apparatus including a connector included in an endoscope and connected to an endoscope connection portion of a video processor, a fluid feeding apparatus including a tube configured to transmit fluid to the endoscope, a connection detector configured to detect a connection state of the tube with the connector of the endoscope, a control unit configured to detect an ON/OFF state of a power source of the fluid feeding apparatus, determine an abnormality exists when the connection detector detects that the tube is in a disconnected state with the connector of the endoscope and the power source of the fluid feeding apparatus is detected to be in an ON state, and output a notification of the determined abnormality, and a display configured to display the notification of the abnormality outputted by the control unit.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An object of the present invention is to provide a technique for detecting human TLR7. Human TLR7 in a sample can be detected through an ELISA method or the like using an anti-human TLR7 antibody. The present invention enables use of human TLR7 as a marker indicating the pathological condition of an autoimmune disease.

Abstract: The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Abstract: An endoscope insertion shape observation apparatus has a processor configured to detect an insertion shape of an insertion portion inserted into a subject P, and calculate operation information, including one of easy insertion information or difficult insertion information, of insertion operation obtained in operation of inserting the insertion portion. The operation information is determined based on an insertion length of the insertion portion. The processor is also configured to simultaneously display of a result of the generation and the insertion shape on the monitor, and change between the easy insertion information and the difficult insertion information.

Abstract: The present invention provides a novel antibody targeting TLR9.

Abstract: An endoscope insertion observation apparatus includes a processor designed to perform functions including: detecting an insertion state of an insertion portion of an endoscope that is insertable into and extractable from a subject; determining whether or not the insertion portion has reached a second site in the subject from a first site in the subject and/or whether the insertion portion has reached the first site from the second site in the subject based on a detection result of the insertion state; and calculating a duration of movement of the insertion portion from the first site to the second site after determining that the insertion portion has reached the second site, or a duration of movement of the insertion portion from the second site to the first site after determining that the insertion portion has reached the first site.

Abstract: An endoscope apparatus including a connector included in an endoscope and connected to an endoscope connection portion of a video processor, a fluid feeding apparatus including a tube configured to transmit fluid to the endoscope, a connection detector configured to detect a connection state of the tube with the connector of the endoscope, a control unit configured to detect an ON/OFF state of a power source of the fluid feeding apparatus, determine an abnormality exists when the connection detector detects that the tube is in a disconnected state with the connector of the endoscope and the power source of the fluid feeding apparatus is detected to be in an ON state, and output a notification of the determined abnormality, and a display configured to display the notification of the abnormality outputted by the control unit.

Abstract: An endoscope insertion shape observation apparatus includes an insertion section configured to be inserted into a subject, and a processor that detects an insertion shape of the insertion section, generates an insertion shape image representing the insertion shape, generates a body outer shape image representing a body outer shape of the subject, and performs display control to simultaneously display the insertion shape image and the body outer shape image in a positional relationship corresponding to a positional relationship, in a body cavity of the subject, of the insertion section on a display screen. The display control also switches between display or non-display of the body outer shape image or a type of the body outer shape image depending on an insertion position, in the body cavity of the subject, of the insertion section.

Abstract: An object of the present invention is to provide a highly-safe and highly-specific preventive or therapeutic agent for inflammatory diseases targeting a TLR7 or TLR9 molecule. The present invention provides a preventive or therapeutic agent for inflammatory diseases containing an anti-TLR7 antibody or anti-TLR9 antibody.

Abstract: An endoscope insertion shape observation apparatus includes an endoscope, a magnetic field generation coil provided at an insertion portion of the endoscope and configured to generate a magnetic field, an antenna unit configured to receive a coil signal from the magnetic field generation coil, a bending portion configured to bend the insertion portion, a bending drive section configured to drive the bending portion to bend, an insertion shape processing circuit configured to generate an insertion shape of the endoscope inserted into a subject according to a signal received from the antenna unit, a touch panel configured to display a generation result of the insertion shape processing circuit and be able to perform touch operation, and a drive section control circuit configured to control a drive amount of the bending drive section based on the touch operation on a desired location of the insertion shape displayed on the touch panel.