Patents by Inventor Kent C. Dooley

Kent C. Dooley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, &agr;-hydroxyketones and hexose phosphates for newborn screening
    Patent number: 6800489
    Abstract: Tandem mass spectrometry (MS/MS) has been used extensively for solving various biological problems, such as structure identification of oligopeptides, nucleic acids, and nucleotides. One of the main advances of MS/MS is that it lends itself to the quantitative and qualitative analysis of certain analytes and complex mixtures with little or no clean up. Quantitative analysis of amino acids and acylcarnitines using tandem mass spectrometry used to screen neonatal dried blood spot samples for disorders in the metabolism of amino acids, organic acids and fatty acids is an emerging technology. The method described herein extends the use of tandem mass spectrometry to the analysis of &agr;-hydroxyketones and hexose phosphates from blood spots for newborn screening. Thus, according to this invention one test can be used to screen a number of neonatal disorders and diseases.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: October 5, 2004
    Assignee: Izaak Walton Killam Health Center
    Inventor: Kent C. Dooley
  • Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, alpha-hydroxyketones and hexose phosphates for newborn screening
    Publication number: 20030228704
    Abstract: Tandem mass spectrometry (MS/MS) has been used extensively for solving various biological problems, such as structure identification of oligopeptides, nucleic acids, and nucleotides. One of the main advances of MS/MS is that it lends itself to the quantitative and qualitative analysis of certain analytes and complex mixtures with little or no clean up. Quantitative analysis of amino acids and acylcarnitines using tandem mass spectrometry used to screen neonatal dried blood spot samples for disorders in the metabolism of amino acids, organic acids and fatty acids is an emerging technology. The method described herein extends the use of tandem mass spectrometry to the analysis of &agr;-hydroxyketones and hexose phosphates from blood spots for newborn screening. Thus, according to this invention one test can be used to screen a number of neonatal disorders and diseases.
    Type: Application
    Filed: June 5, 2002
    Publication date: December 11, 2003
    Inventor: Kent C. Dooley